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N A LABZOFFSKY

Publications and source records attributed to N A LABZOFFSKY.

At least 19 recordsLinked to original sources
PubMed1965

A SURVEY OF TOXOPLASMOSIS AMONG MENTALLY RETARDED CHILDREN.

To determine what role, if any, toxoplasmosis plays in the mental retardation of children, sera from 345 mentally retarded children were tested for the presence of antibodies to Toxoplasma gondii. The serological tests employed were the complement-fixation, the Sabin-Feldman dye test and the immunofluorescence test. The donors were also skin-tested with toxoplasmin.Of 345 mentally retarded donors nine gave a positive skin reaction, 15 possessed complement-fixing antibodies, 21 had immunofluorescent antibodies and 45 had dye test antibodies to T. gondii.The incidence of antibodies to T. gondii in the mentally retarded group was approximately the same as in the normal control group of the same age, and less than in the group suspected of having toxoplasmosis. It is concluded that in the children in this study toxoplasmosis played little or no role as a predisposing factor in the occurrence of congenital mental deficiency.

Adolescent↗
PubMed1964

SPORADIC OCCURRENCE OF ECHO VIRUS TYPES 27 AND 31 ASSOCIATED WITH ASEPTIC MENINGITIS IN ONTARIO.

The sporadic occurrence of Echo virus types 27 and 31 in association with aseptic meningitis during the enterovirus seasons in Ontario in 1959 to 1962 is reported.The etiological significance of both of these isolates was verified by demonstration of type-specific serological response in meningitis patients. Echo 27, which up to now has not been encountered in association with human illness, could be added to the list of viral agents capable of causing aseptic meningitis. Isolation of Echo 31 from cerebrospinal fluid provides definite proof of the etiological significance of this virus in cases of aseptic meningitis.

Canada↗
PubMed1964

AN OUTBREAK OF ASEPTIC MENINGITIS DUE TO ECHO 25 VIRUS.

In a widespread outbreak of aseptic meningitis during the summer and early fall of 1961 in Ontario, Echo type 25 virus was found to be the predominant virus type isolated from affected patients. Recovery of Echo 25 virus in several cases from the CSF of patients strongly suggests an etiological relationship between this virus type and the illness. The causative role of the virus was confirmed by demonstration of significant immunological response in patients found to be infected with the virus. The presence of antibodies to Echo 25 virus in about 70% of meningitis patients, from whom no virus was isolated, indicates that the infection in the population of the affected areas was much more prevalent than the number of successful virus isolations would suggest. It is recommended that Echo 25 virus should be added to the series of Echo virus types capable of causing outbreaks of aseptic meningitis.

Adolescent↗
PubMed1964

IMMUNOFLUORESCENCE AS AN AID IN THE EARLY DIAGNOSIS OF TRICHINOSIS.

The established serological tests for trichinosis are often negative during the period when laboratory investigation is most likely to be useful.Another serological test, the immunofluorescence test, appears to be more promising in this respect. The results were based on studies involving experimental animals and human patients. In two rabbits orally infected with Trichinella spiralis larvae, antibodies were demonstrable by immunofluorescence on the fourth day after infection, by complement fixation on the eighth and tenth days, and by the precipitin test on the thirteenth and twenty-eighth days, respectively. In three human cases the immunofluorescence antibody test was positive two weeks (the earliest blood samples available) after onset, while precipitin and complement fixation tests did not become positive until the end of the fourth week. The immunofluorescence test thus becomes positive at least two weeks earlier than the other two, a factor which undoubtedly increases its value in diagnosis.

Animals↗
PubMed1963

ISOLATION OF ENTERIC VIRUSES IN ONTARIO DURING 1960-1962.

During the past three years at the Central Laboratory, Ontario Department of Health, 681 isolations were made in tissue culture from 6822 specimens submitted for virus studies by physicians and hospitals from all over Ontario. Nearly 74% of the isolates were enteroviruses, approximately 5% adenoviruses and about 1% reoviruses. The remaining 20% are still to be identified.Although the bulk of isolations was made during the same three-month period (August, September and October) of each year, the predominant virus types varied from year to year. Poliovirus 1 was most commonly encountered in 1960, Coxsackie B5 in 1961 and Echo 9 in 1962.Among other types isolated in smaller numbers were Coxsackie A1, 9 and 10, Coxsackie B1, 2, 3 and 4, Echo 1, 2, 5, 6, 7, 8, 11, 14, 17, 18 and 19, Reovirus 1, 2 and 3, Adenovirus 1, 2, 3, 4, 5, 7 and 16, as well as Frater-type virus. Most of these types were isolated for the first time in Ontario and represent additions to the existing list of viruses known to occur in this province.

Adenoviridae↗
PubMed1963

Aseptic meningitis due to Frater type virus in Ontario.

During the summer and fall of 1959 and 1960 a virus was isolated on 14 occasions from the stool or cerebrospinal fluid or both of 12 patients with a clinical picture of non-paralytic poliomyelitis or aseptic meningitis. The patients were from eight different localities in Ontario. The isolated virus was not neutralized by antisera to any of the known enteroviruses, reoviruses or adenoviruses, nor did antiserum to the isolate neutralize any of these viruses. Antiserum to Frater virus, however, did neutralize this isolate and in turn was itself neutralized by antiserum to this virus. Frater virus was isolated in Scotland from cases of aseptic meningitis during the same period in 1959 and 1960. In Ontario this virus was not encountered before 1959. Isolation of the virus from cerebrospinal fluid and demonstration of immunological response in the patients establish its etiological significance. Biological characteristics indicate that it belongs to the Echo group.

Adenoviridae↗
PubMed1962

Occurrence of reovirus infection in Ontario.

Reovirus Type 2 was isolated from three patients aged 5, 9 and 10 years. The etiological role of Reovirus in one case was confirmed by demonstration of antibodies in convalescent serum and none in acute serum. Symptoms in this case were suggestive of infectious mononucleosis. In the second case, rhinitis and non-purulent otitis were preceded by two waves of fever, abdominal pain and emesis. Acute serum was not available but convalescent serum had a high titre to a Reovirus, thus supporting a Reovirus etiology. Symptoms in the third case were fever, intermittent headache, neck stiffness, abdominal cramps and weakness of a leg. Because of the unavailability of convalescent serum, evidence of a Reovirus etiology was incomplete. No attempt is made to associate Reovirus with a particular clinical picture. Rather, attention is simply drawn to the existence of Reovirus infections in Ontario.

Female↗