PubMed Health⌕ Search

Biomedical subjects

N A Lebedeva

Publications and source records attributed to N A Lebedeva.

8 recordsLinked to original sources
PubMed1977

[Electrophoretic study of muscle extracts of low ionic strength].

The method of Na-dodecylsulfate electrophoresis in polyacrylamide gel demonstrated that the so-called tonoactomyosin of smooth muscles extracted from the muscle homogenate with salt media of low ionic power represented a complicated protein system into whose composition there was included a heavy myosin chain with the mol wt of 210000, premyosin subunit with the mol wt of 230000, actin, and, possibly, a number of other proteins. The extracts of low ionic power possessed Mg2+ and Ca2+ activated by ATP-ase activity. The premyosin subunit was also revealed in the extracts of low ionic power from the skeletal muscle homogenates. It is supposed that premyosin subunit was included into the enzymatic system responsible for the ATP-asic properties of the extracts of low ionic power from the homogenates of different types of muscles.

Actomyosin↗
PubMed1975

[Changes in the protein and energy metabolism and their correction in patients with circulatory insufficiency].

Chronic hypoxia arising in cases of circulatory insufficiency brings on changes in all kinds of metabolism, including that of energy and protein. Patients suffering from circulatory insufficiency should be treated with due regard for metabolic shifts occurring in cases of cardiac incompetence. A total of 180 patients with circulatory insufficiency of the I-IIIstage were examined by employing up-to-date methods in studying the state of the energy, carbohydrate, protein, amino acids metabolism and the hepatic function. The patients underwent medication with drugs influencing the metabolic processes and with combinations of such drugs and the clinical effect of such a type of the treatment is assessed.

Adenosine Triphosphate↗
PubMedDate not supplied

[Age peculiarities of actomyosin enzymic properties in embryogenesis].

Age changes in the subunits composition were comparatively studied for protein, ATPase activity, sensitivity to Ca2+ in low concentrations and alkaline activation of ATPase of natural actomyosin of skeletal muscles and myocardium in cattle feti. A rise in values in the process of the mentioned parameters development is established for actomyosin of skeletal muscles. The rise is especially considerable by the end of embryonic development. Correspondingly the myocardium actomyosin possesses a lower ATPase activity and higher sensitivity to Ca2+ in low concentrations. The ATPase activity rises moderately with development.

Actomyosin↗
PubMedDate not supplied

[Changes in properties of actomyosin in the process of ontogenesis].

The paper deals with some data on nonidentical heat-resistance of actomyosin of the skeletal muscles and myocardium of the calf foetus and adult animals. It is shown that in the process of uterine development the ATPase activity increases and at alkaline pH the Ca2+-activated ATPase of natural actomyosin of the cattle skeletal muscles and myocardium is activated. Heat-resistance of ATPase of the skeletal muscles and myocardium decreases with age, the myocardium actimyosin ATPase being more stable to heating. These denatured changes are found to be of a reversible character.

Actomyosin↗
PubMedDate not supplied

[Triiodothyronine thyrotoxicosis in nodular toxic goiter].

Serum protein-bound iodine (PBI), total blood thyrotoxin (T4), triiodthyronine (T3), coefficient of thyrotoxin efficacy (CTE), serum thyrotoxin-binding capacity (TBC) or some of these indices were determined in 44 patients with nodular toxic goiter with thyrotoxemia. An increase in T3 level was revealed in 27 of 35 of the patients; T3-thyrotoxicosis was diagnosed in 18 of these in whom an increase of the T3 level was combined with normal T4 or normal CTE content and an unchanged TBC. The symptoms of T3-thyrotoxicosis displayed no significant differences from the symptoms of thyrotoxicosis caused by the excess of thyroxin. In many of the patients T3-thyrotoxicosis coursed for a long time with but a few symptoms. Loss of weight in this form of thyrotoxicosis was much less frequent than in "thyrotoxin'' thyrotoxicosis. PBI was elevated in 12 of 44 patients, and total T4 and CTE -- in 10 of 35. These methods do not permit to diagnose hyperthyroidism in many of the patients with nodular toxic goiter in which T3-thyrotoxicosis is of frequent occurrence.

Adult↗