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Biomedical subjects

N A Logue

Publications and source records attributed to N A Logue.

2 recordsLinked to original sources

Extraversion and the McCollough effect.

Two experiments are reported which show that extraverts experience significantly stronger McCollough Effects than introverts. In both experiments the strength of the McCollough Effect (ME) was measured by the match-interference method devised by Shute (1979). The technique was found to be predictably sensitive to the eye tested and to exposure of the non-adapted eye. In the first experiment monocular ME strength was measured at 12-min intervals over two hours in four conditions and found to conform to a power function. Sixteen extraverts showed significantly (p < .00005) stronger initial ME strength than 21 introverts and in both groups the effect ceased to be apparent within about two hours. Log-log plots of decrement from initial strength indicated no significant extraversion differences in decay rates, with a function gradient of about 1/2. In a second experiment six extraverts and nine introverts from the original group were retested with binocular presentation with a similar outcome. These findings support Shute's hypothesis that introverts would show weaker MEs than introverts but do not support his hypothesis that introverts' MEs would decay more quickly. They offer some indirect support for Shute's proposal that the ME may be an indicator of central cholinergic activity in man.

Adolescent

The McCollough effect as a measure of central cholinergic activity in man.

The McCollough Effect (ME) is an orientation contingent colour after-effect which has been proposed as an indicator of central neurotransmitter activity. Shute (1979) suggested that the ME could reflect a hippocampal "forgetting" mechanism which should be inhibited by GABAergic neurones and stimulated by cholinergic neurones. The purpose of the present study was to demonstrate that the ME is in fact sensitive to cholinergic and anticholinergic drugs and to compare its sensitivity to more conventional tests of psychomotor and cognitive function. Ten healthy subjects received single doses of physostigmine (0.75 mg SC), hyoscine (1.2 mg), temazepam (20 mg), flecainide (200 mg) or placebo in a double-blind double-dummy presentation. Subjects were tested on a battery of psychomotor and cognitive function tests at baseline and 1 h, and adapted to the ME at 1.5 h. Visual analogue rating scales and conventional tests of psychomotor function and saccadic eye movements indicated that both subjective and objective measures of arousal were impaired by temazepam. The subjective, but not the objective, measures of arousal were also impaired by both hyoscine and physostigmine, but not by flecainide. Initial strength and duration of the ME were decreased by physostigmine and increased by hyoscine and temazepam, relative to placebo (P less than 0.01). Thus, the ME is capable of detecting cholinergic, anticholinergic and GABA mimetic drug effects in man, in therapeutic doses.

Adaptation, Ocular