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Biomedical subjects

N A Mokhort

Publications and source records attributed to N A Mokhort.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Histamine. Its action on the heart and vessels].

The literature data on the effect of histamine on the heart and vessels in different species of animals and man were analyzed. Nonheterogeneity of histamine effect can be presumably explained by a strong representation of various types of receptors to which this biogenic amine is bound (H1, H2, H3) in the organs and tissues, their unequal location on the pre- and postsynaptic membrane, the differences in their physiological functions.

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PubMedDate not supplied

[Cardiovascular effects of histamine mediated by H1- and H2-receptors].

Histamine was found to suppress the myocardial contractile function, to decrease systemic arterial blood pressure and to exert a positive chronotropic effect in unanesthetized dogs. A preliminary blockade of H1-receptors prevented the hypotensive effect of histamine, blockade of H2-receptors prevented the development of the positive chronotropic effect.

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PubMedDate not supplied

[Anti-inflammatory, analgesic and antipyretic activity of pyrimidant].

In experiments on rats with different models of pathology it was demonstrated that a new non-steroidal anti-inflammatory drug pyrimidant exerts pronounced anti-inflammatory, analgesic and antipyretic effects. In some cases its activity exceeds that of indomethacin, brufen, butadione, mefenamic acid, sodium salicylate.

Animals↗