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Biomedical subjects

N A Ognerubov

Publications and source records attributed to N A Ognerubov.

17 recordsLinked to original sources
PubMed2003

[Urokinase and tissue type plasminogen activators and their type-1 inhibitor (PAI-1) in gastric cancer].

The levels of urokinase (uPA) and tissue type (tPA) plasminogen activators and their type 1 inhibitor (PAI-1) were determined by immunoassay in tumor cytosols and samples of histologically unaltered adjacent mucosa in gastric cancer patients. Gastric tumor revealed enhanced uPA and PAI-1 matched by decreased tPA in intact mucosa. The expression of uPA and PAI-1 was particularly was high at the later stages of the disease. The concentrations of uPA in tumor tissue increased with age. No significant correlation was established between levels of plasminogen activation system components, on the one hand, and histopathological grading of tumor, on the other.

Adolescent↗
PubMedDate not supplied

[The role of epithelial antigens in diagnosis and staging of breast cancer].

The study of different epithelial antigen expression has been performed in 183 breast cancers. In 73 patients regional lymph nodes were studied as well. Panepithelial antigen Egp-34 (Mab HEA-125) was expressed in 100% of primary tumors and metastases. Antigen MUC-1 (Mab ICO-25) was identified in 93% of breast cancers. Monomorphic type of expression in tumor cells was typical for Egp-34, MUC-1 being in certain cases expressed as a proportion of cells. Additional immunohistochemical study of regional lymph nodes with Mab to Egp34 and MUC-1 provides a 10% increase in the rate of breast cancer metastases detection compared to histological examination alone. The carcinoembryonic antigen (CEA) was useful in identification of metastases only in CEA-positive breast cancers.

Adult↗
PubMedDate not supplied

[Granulomatous thymitis with stromal amyloidosis].

In a surgically removed thymus of an 18 year old man granulomatous thymitis with lymphoid follicles, amyloidosis, pseudocysts were observed. Rare occurrence of this pathology, difficulty of the diagnosis, absence of the treatment concept make surgery a method of choice.

Adolescent↗
PubMedDate not supplied

[Magnetic resonance imaging in diagnosis of localized prostatic cancer].

To evaluate efficacy of MR imaging (MRI) in diagnosis of local prostatic cancer (LPC) and validity of MRI performance in patients with high levels of prostate-specific antigens (PSA), we made a retrospective analysis of a combined examination of 210 patients including MRI (100%). Of them, 68 (32.4%) had prostatic cancer (LPC pT1-pT2 in 27 patients, 39.7%), 87 (41.4%) had benign prostatic hyperplasia (BPH) and 35 (16.7%)--chronic prostatitis (CP). 17 (8.1%) patients were free of prostatic diseases. MRI accuracy in diagnosis of LPC was 60%, sensitivity 70%, specificity 54%, in positive and negative prognostic values 50 and 73%, respectively. Some features of LPC were seen in MRI of BPH, CP and control patients. MRI symptoms characteristic for one of the above diseases only were not determined. We believe that MRI is indicated in suspected prostatic cancer located in the central zone and anterior lateral regions of the peripheral zone (unpalpable prostatic cancer). Prostatic MRI with assessment of the lower spine and pelvic bones is justified in men over 50 years if PSA is above 10 ng/ml. Early and accurate diagnosis of LPC by MRI is impossible without evaluation of clinical and PSA data.

Adult↗