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N A Osipova

Publications and source records attributed to N A Osipova.

At least 19 recordsLinked to original sources
PubMed1992

[Last-generation synthetic opioid analgesics as alternative to opiates in oncologic surgery].

The present-day problem is the development of effective methods of general anesthesia and postoperative anesthesia on the basis of nonopiate central analgesics possessing no hazardous side effects of opiates. A study was made of synthetic analgesics of the last generation as agents for intra- and postoperative anesthesia as compared with conventional opiates. It has been established that synthetic analgesics belonging to the class of opiate agonists-antagonists, namely moradol and norphine, compare favourably enough with fentanyl. They are superior to fentanyl in antistressor properties, provide for a more powerful and longer analgesic effect and can replace conventional opiates in all the stages of surgical treatment of the patients. This is particularly important for the oncological clinic where opiates are to be preserved as reserve for the treatment of chronic painful syndrome.

Analgesics↗
PubMed1987

[Individual differences in the levels of pain sensitivity and analgesic effect of morphine in noninbred mice].

The initial threshold of pain sensitivity and the degree of morphine analgesia (12, 12, 70 mg/kg, i. p.) were assessed during mechanical, thermal and electrical stimulation, respectively, in noninbred white male mice. Two tests were performed, the second a week after the first one. A slight positive correlation (r = +0.39) between the initial threshold of pain reaction and the analgetic effect of morphine was found only during electrical stimulation in the first test, and positive correlation between the first and the second test during electrical and mechanical stimulation (0.34 and 0.27, respectively) was determined. The degree of morphine analgesia in different animals during second testing could either increase or decrease. It is suggested that previous testing of morphine analgetic effect cannot predict the efficacy of analgesia during the second testing and that the initial threshold of pain sensitivity cannot serve as a reliable predictor of morphine analgesia level.

Animals↗
PubMedDate not supplied

[Preventive analgesia: a new trend in anesthesiology. An idea born and developed at the P.A. Herzen Institute of Oncology].

The authors summarize positive experience gained in the use of preventive anesthesia in oncosurgery. The new trend in anesthesiology has been developed at P. A. Herzen Institute of Oncology since the end of the eighties. A peripheral analgesic (aspisol, ketoprofene, ketorolac, etc.) was added to traditional premedication and anesthesia protocols in 522 patients subjected to extensive cavitary and other than cavitary surgery. Hemodynamic and metabolic parameters, homeostasis, stress criteria (hydrocortisone and glucose), pain intensity according to the verbal evaluation scale were studied at all stages of anesthesia and postoperative period, and side effects of postoperative analgesia were analyzed. Use of nonsteroid antiinflammatory drugs before the intervention and in the postoperative period prevented the development of strong postoperative pain and notably decreased the need in opioid analgesics in the presence of stable homeostasis. No serious side effects of analgesics, including hemorrhagic complications, were observed.

Adult↗