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Biomedical subjects

N A Peresadin

Publications and source records attributed to N A Peresadin.

At least 19 recordsLinked to original sources
PubMed1994

[The pathogenetic role of circulating immune complexes in multiple sclerosis].

CIC in multiple sclerosis were assessed qualitatively and quantitatively. CIC changes in response to hormone therapy were also studied. It was found that in multiple sclerosis CIC contain antibodies to brain tissue, thymus, hepatic lipoprotein, adrenal cortex, leukocytes, gastric mucosa. A positive response of CIC levels to hormone treatment is stated.

Adolescent↗
PubMed1994

[Use of an "immunologic compass" for diagnosis of immune disorders in clean-up crew members after the accident at the Chernobyl nuclear power plant].

A total of 389 patients with cerebrovascular diseases who participated in liquidation of the Chernobyl power plant accident consequences were examined using rosette formation test and the cytotoxic method with monoclonal antibodies (MCAB). The predominant type of immunologic abnormalities found in 79.1% of patients was a marked reduction of CD4+ cell (T-helpers/inductors) count and a moderate reduction of CD8+ (T-suppressor/keller) count, this resulting in reduction of the CD4/CD8 coefficient. In 11.3% of the examinees CD(4+)-lymphocyte count was reduced and CD8+ count was within the normal range, in 6.2% both CD4+ and CD8+ counts were reduced, and in 3.4% CD4+ count was reduced and CD8+ moderately elevated. Results of theophylline test did not coincide with those of CD4+ and CD8+ measurements in 44.2% of cases.

Accidents↗
PubMed1993

[Immunity indices in the diagnosis of persistent HBs-antigenemia in pregnant women].

The immunity parameters were studied in 42 pregnant women, HBsAg carriers, both clinically healthy and suffering from chronic liver diseases. Sixty pregnant women without liver diseases or HBs-antigenemia made up the reference group. A marked T-cellular immunodeficiency was revealed in pregnant women with persistent HBs-antigenemia and chronic persistent hepatitis, in contrast to the clinically healthy women whose cellular immunity parameters were the same as in healthy pregnant women. Besides cellular immunodeficiency, the pregnant women with HBs-positive chronic persistent hepatitis presented with a marked imbalance of the humoral immunity parameters and hypersensitization to liver lipoprotein, this indicating manifest shifts in the immunity system. Spontaneous abortions occurred much more often in women with chronic persistent or active hepatitides than in the controls. The authors claim that screening of pregnant women for HBsAg is advisable for deciding on the policy of pregnancy management.

Adult↗
PubMed1993

[Secondary immunodeficiencies in the pathogenesis of protracted forms of intestinal infections and the prospects for their immunocorrection].

Acute intestinal infections (AII) are characterized by marked defects of immune homeostasis. These were not related to the disease etiology though depended on the infection severity and manifested with T-lymphopenia, reduced count of circulating T-helper cells in normal amount of T-suppressor cells. This resulted in low immunoregulatory index (CD-4/CD-8). Immunological criteria have been determined indicative of the tendency to formation of a protracted AII course and long-term persistence of the agent in the host.

Acute Disease↗
PubMed1992

[The clinical assessment of macrophage functional activity in patients with protracted dysentery and its correction with lysozyme and vitamin E].

Prospects for the correction of disturbances in the macrophagal system with a combination of lysozyme and vitamin E in patients with a protracted course of dysentery caused by Shigella flexneri 1b were studied. The phagocytic activity of macrophages (PAM) was found to be suppressed as early as at the beginning of the disease. Out of 38 persons repeatedly found to release shigellae 24 were administered polychemotherapy. PAM indices in patients treated with lysozyme and tocopherol acetate were likely to normalize, this being indicative of the positive effect of these preparations on the functional activity of the macrophagal system.

Adult↗
PubMed1992

[Combined chemotherapy of toxic hepatitis in patients with pulmonary tuberculosis].

The follow-up involved patients with infiltrative pulmonary tuberculosis who developed toxic medicamentous hepatitis associated with antituberculosis drugs. They were treated by the method of combined pharmacotherapy which comprised sodium nucleinate (0.5 g 4 times daily), splenin (2 ml twice a day) and quercetin. The given combination of drugs rapidly improved clinical parameters and normalized immunologic tests.

Adult↗
PubMed1992

[Use of vilozen and ketotifen combination for increasing the effectiveness and prevention of complications of antibiotic therapy of streptococcal infections].

The clinical efficacy of a vilozen and ketotifen (zaditen) combination in the treatment of streptococcal infections along with the routine therapy was studied. The use of the combination was shown advisable in the complex therapy and prevention of relapses in patients with streptococcal infections. The combined pharmacotherapy promoted better clinical indices, normalization of the immune status and a reduction in the incidence of allergic reactions to antibiotics and a decrease in sensitization to bacterial allergens.

Adjuvants, Immunologic↗
PubMed1992

[The tocopherol acetate and splenin correction of the immunological disorders in patients with viral hepatitis B].

Inclusion of tocopherol acetate and splenin into complex treatment of viral hepatitis B (VHB) ensures a marked immunomodulating effect consisting in control of T-lymphopenia, normalization of helper-suppressor ratio, reduction of circulating immune complexes and a tendency to restoration of normal ratio between separate fractions of immune complexes, stimulation of phagocytic activity of monocytes of the peripheral blood. Splenin and tocopherol acetate are recommended in the complex treatment of hepatitis B.

Adjuvants, Immunologic↗
PubMed1992

[The antioxidant treatment of patients with acute intestinal infections due to gram-negative microorganisms].

It was established that administration of S. typhimurium lysate causes activation of the processes of free-radical oxidation. Introduction of unithiol in combination with magnesium sulfate returns the intensity of these processes to the initial level. Unithiol and alpha-tocopherol acetate protect the animals form lethal effects of S. sonnei lysate. Use of a combination of pharmacological agents consisting of unithiol, magnesium sulfate and alpha-tocopherol acetate in the treatment of patients with acute intestinal infections due to gram-negative pathogens (shigellae, salmonellae, proteus, klebsiellae, pseudomonas) resulted in decrease of the length of the intoxication and diarrhea syndrome, decrease of the frequency of repeat bacteria elimination and protracted forms of these infections, more rapid normalization of immune system functions.

Acute Disease↗
PubMed1992

[The clinical assessment of the immune status of patients with acute Flexner shigellosis].

A total of 192 patients with Flexner's dysentery 1 have been examined. As a result, sharply pronounced unbalance of cell-mediated and humoral immunity factors has developed in the acute period of dysentery, reaching its maximal manifestations in severe course of the disease. In case of a tendency to a prolonged course of dysentery at the period of convalescence, essential shifts in immunological characteristics persist and the infective agent is repeatedly isolated.

Acute Disease↗