Biomedical subjects

N A Rjabucha

Publications and source records attributed to N A Rjabucha.

3 recordsLinked to original sources

PubMed1987

[Morphometric picture of chronic bronchitis in bronchiectases--morphologic and morphometric changes in the proximal and distal bronchi and bronchioles].

Morphological specific features of proximal and distal bronchi and bronchioles were studied in secondary chronic bronchitis as compared to the primary one basing on the morphometric data. Some specificity was noted in separate forms of secondary bronchitis. Secondary chronic bronchitis is characterized by non-uniform pathological changes in bronchial walls. Wall enlargement, infiltration and sclerosis are more pronounced in secondary chronic bronchitis as compared to the primary one. The relative volume of glands and muscles is less in secondary chronic bronchitis than in the primary one; the Reid index does not differ from the standard in spite of the enlargement of the mucosal inner layer. Atrophic bronchitis is characterized by thinning of mucosal inner layer and decrease in the number of glands. Secondary chronic bronchitis is characterized by narrowing of bronchioles, in contrast to the primary chronic bronchitis where the mean diameter of bronchioles is extended.

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PubMed1981

[Morphometric investigations of the bronchial tree in chronic bronchitis. Part I. The alterations of lumen and thickness of the walls of bronchi and bronchioli (author's transl)].

The morphometry of bronchi and bronchioles was studied in 22 persons aged between 47 and 78 who had died after suffering from chronic bronchitis for many years. Additionally the lungs of five persons, died due to other reasons and never having suffered from chronic bronchitis (normal persons) were investigated. In compared to the normal conditions no essential alterations in the diameter of the lumen could be found in the proximal bronchi (including the main bronchus till down to the subsegmental bronchus of the third order). The mean diameter of the lumen of distal membranous bronchi is unchanged, as well, but bronchioles in chronic bronchitis has a bigger lumen amounting to 0.4515 +/- 0.027 mm (in normals 0.324 +/- 0.024 mm, P less than 0.05). The calibres in the terminal and respiratory bronchioles varied as follows: Ectasia in 58%, stenosis in 11%, without any alterations in 31%, that means: organic stenosis in the distal bronchi and bronchioles is of minor importance for the mechanisms of obstruction in chronic bronchitis. The thickness of the proximal and distal bronchi is enlarged in chronic bronchitis. As to the histological features lympho-cytoplasmocytic infiltrations of the mucous membrane could be found in nearly all proximal bronchi studied (in 97.5%), sclerosis of the wall in 32.6%, and metaplasia of the lining squamous epithelium in 15%. Cytology of the bronchial secretions revealed the predominance of neutrophiles among all cellular elements when the inflammatory process was exacerbating.

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PubMed1981

[Morphometric investigations of the bronchial tree in chronic bronchitis. Part II. The morphology of tissue alterations of the bronchial walls. (author's transl)].

The data of the literature and the methods of this investigation have been discussed in the previous paper. The present report (21 cases of chronic catarrhal bronchitis and one case of chronic atrophic bronchitis) is containing the morphometric results of tissue changes in the bronchial walls of four proximal bronchial generations. In the catarrhal form of chronic bronchitis in contrast to normal conditions the Reid's index increases about two folds, its value being about equal for the main, labor, segmental and subsegmental bronchi of the first order. In catarrhal chronic bronchitis the relative volume (in %) of the bronchial glands of the bronchial walls increases in the same bronchial generations, vice versa, relative the volume of the connective tissue decreases, but the relative volume of the smooth muscle and of the cartilaginous discs has been found to be unchanged. This volume of the bronchial glands to periphery (from the main bronchus to the subsegmental) has been demonstrated to decrease a little (not significantly). The relative volume of smooth muscles and of the connective tissue increases. Morphometric findings could be obtained only in one case of atrophic chronic bronchitis; therefore they are inadequate for statistic analysis.

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