[Mechanism of stimulation of duodenal contractions by the greater splanchnic nerve].
The mechanism of duodenal motor activity stimulation has been studied in dogs during irritation of the chest area of the greater splanchnic nerve. It has been established that a stimulating effect of the splanchnic nerve was not removed either by bilateral vagotomy or by separate and combined injections of bretylium tosylate and benzohexamethonium, but was removed by the blockade of M-serotoninergic receptors of the autonomic ganglia with atropine or by the blockade of D-serotoninergic receptors of the smooth muscles with promethazine hydrochloride. The data obtained demonstrate the presence of noncholinergic and nonadrenergic fibers in the chest area of the greater splanchnic nerve, having a potent stimulating effect on duodenal contractions. According to our functional and biochemical tests, they are mediated by serotonin.