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Biomedical subjects

N A Vlasov

Publications and source records attributed to N A Vlasov.

At least 19 recordsLinked to original sources
PubMed1987

[Psychosomatic and humoral correlations of persons in late middle age].

Comprehensive examination of psychoemotional personality characteristics, electropolygraphic examination during night sleep and in various states of day-time wakefulness, as well as determination of the circadian rhythm of urinary catecholamine excretion were carried out in elderly patients versus control subjects. A correlational analysis of the findings obtained revealed certain changes of the studied indicators in the elderly patients. Nocturnal sleep was associated with elevated functional activity of the ascending activating system of the brain and with increased noradrenaline excretion. In day-time wakefulness the dynamics of physiologic, psychologic and biochemical changes were of the unidirectional nature: a decrease in reactivity of alpha-index was logically combined with decrease in reactive anxiety and in noradrenaline and dopamine secretion.

Aged↗
PubMed1987

[Various aspects of the pathogenesis, clinical picture and treatment of migraine].

In a series of 108 patients with migraine the authors studied the characteristics of the emotional-personality sphere and autonomic nervous system, as well as the status of the brain nonspecific systems. The findings of nocturnal electropolygraphy were also used in the study. The efficacy of drugs with antiserotonin action versus multiple modality therapy was compared. The observed disorders in the psychic, autonomic and endocrine systems are interpreted as a consequence of dysfunction of the central integrative cerebral apparatuses. The most effective approaches toward the multiple modality therapy of migraine patients have been developed.

Adolescent↗
PubMed1986

[Psychophysiologic interrelations in healthy subjects and alcoholics in remission].

Twenty male patients suffering from alcoholism (10 at the second and 10 at the third stage of disease) at the phase of a remission were subjected to electropolygraphic examination during night sleep and relaxed wakefulness. The mental state was examined by MIL and Spilberger's tests. A control group included 14 normal subjects in whom, additionally to the baseline examinations, the authors studied the effect of a single dose of ethanol taken before sleep on the nonspecific cerebral systems. The latter was associated with an increase in the deep stages of sleep and a reduction of the phase of rapid sleep as well as a decrease of the activation parameters. The electropolygraphic and psychological characteristics in patients with alcoholism of stage II and III showed no significant differences, yet both groups differed considerably from healthy subjects which was expressed in the intensified desynchronization of the cerebral bioelectrical activity in both sleep and wakefulness and in the presence of anxiety-depressive disorders. Hyperfunction of the ascending activating system of the brain seems to be responsible for the above psychophysiological changes.

Adult↗
PubMed1984

[Structure of nocturnal sleep in sleep disorders among middle and late middle-aged patients].

This is a report on the electropolygraphical examination of nocturnal sleep and the study of emotional-personality changes in 53 patients with impaired sleep who were divided into two groups (24 middle-aged and 29 elderly patients). Day-time electropolygraphic examinations were carried out in 39 out of these patients in period of relaxed and alert wakefulness. The patients versus healthy controls showed a reduction in the total duration of sleep, a tendency toward a decrease in delta-sleep, rapid sleep and the number of completed cycles. The patients were further characterized by an increase in the time of falling asleep, the number of spontaneous awakenings and the time of wakefulness in the course of sleep. The elderly as compared with the middle-aged were characterized by a pronounced decrease in night sleep, the duration of Stage II and the number of completed cycles of nocturnal sleep. In the period of alert wakefulness, alpha-responsiveness in some modulated functional states was lower than in the control group.

Age Factors↗
PubMed1978

[Effect of gamma-aminobutyric acid derivatives on sleep disorders in neuroses].

Electropolygraphic studies showed that under gamma-amino-butyric acid (GABA) derivatives various neurotic patients with sleep disorders had a tendency towards an increase in total sleep duration due to an accretion of basic sleep stages (the 2nd stage, delta-sleep, and rapid sleep), a statistically significant reduction in the number of spontaneous wake-ups, time of awakedness during night and the movements activation index. A detailed analysis of some electrographic data within the sleep stages revealed a tendency towards an increase in number of the 2nd stage sleep spindles, of delta-index in the 3rd and 4th sleep stages, as well as an increase in the average readings of rapid eye movements in the absence of any marked changes in their specific occurrence per time unit. GABA derivatives in the used dosage caused similar changes in the sleep patterns in case of its disturbances, with a relatively more pronounced action of sodium oxybutyrate.

Aminobutyrates↗
PubMed1976

[Effectiveness of different methods of treating sleep disorders according to electropolygraphic findings].

The authors report of an electropolygraphical study of 111 patients with different forms of neurotical sleep disorders. For therapeutical purposes different pharmacological methods (Ca cyclobarbital, eunoctin, elenium, difenisid) and psychotherapeutical (hypnosuggestion, autogenic training) treatment was used. The achieved data permit to conclude that there is an increased activity of the awakening and activizing systems in patients with neurotic disorders of sleep. A decrease of the activating changes evoked under the influence of pharmacological and psychotherapeutical methods is accompanied by an improvement of the objective indices and as a rule correlates with a subjective personal feeling of sleep by the patient. The authors studied the optimal conditions for using different methods of treatment and based their principles for a differentiated therapy of different disorders of sleep in neuroses.

Adult↗
PubMedDate not supplied

[Isolation of influenza A/H5N1 virus strains from poultry and wild birds in West Siberia during epizooty (July 2005) and their depositing to the state collection of viruses (August 8, 2005)].

Six strains of influenza AH5N1 virus were isolated, by using PS and MDCK continuous cell lines from poultry and wild birds, which were collected on July 28, 2005 in the samples taken from 5 examines species of wild birds in the Novosibirsk region during the epizootic outbreak with a high mortality. The strains were identified by means of HIT, RT-PCR, and microchip-based techniques. Two strains, A/Grebe/Novosibirsk/29/05 (H5N1) and A/Duck/Novosibirsk/56/05 (H5N1), were deposited to the Russian State Collection of Viruses (Registration Nos. 2372 and 2371, respectively) with the priority date 08.08.2005. Positive results in RT-PCR for influenza A/H5N1 virus detec- tion were obtained in 100% of the samples from dead and sick poultry; 93% from the clinically healthy poultry kept together with sick one; positive results ranged from 0 to 36%. Sequencing established the identity of genetic characteristics of strains isolated for wild birds and poultry as well as their affiliation to high pathogenic avian influenza (HPAI). Phylogenetic analysis revealed a high homology of hemagglutining of West-Siberian strains and strains isoolated from bar-headed gooses (Eulabeia indica) on the Qinghai Lake (Western China) in the 2005 spring.

Animals↗
PubMedDate not supplied

[Highly pathogenic influenza A/H5N1 virus-caused epizooty among mute swans (Cygnus olor) in the lower estuary of the Volga River (November 2005)].

Molecular virological studies of the field material collected in the epicenter of epizooty with high mortality among mute swans (Cygnus olor) in the area of the lower estuary of the Volga River (November 2005) could establish the etiological role of highly pathogenic influenza A (HPAI) virus of the subtype H5N1. Ten HPAI/H5N1 strains deposited at the State Collection of Viruses of the Russian Federation with the priority dated December 1, 2005 were isolated from the cloacal/tracheal swabs and viscera of sick and freshly died mute swans. Complete nucleotide sequences of all fragments of the genome of 6 strains have been deposited in the Gene Bank. The paper discusses the molecular genetic characteristics of isolated strains.

Animals↗
PubMedDate not supplied

[Isolation of highly pathogenic avian influenza (HPAI) A/5H5N1 strains from wild birds in the epizootic outbreak on the Ubsu-Nur Lake (June 2006) and their incorporation to the Russian Federation State Collection of viruses (July 3, 2006)].

Virological and molecular genetic studies of the field material collected in the epicenter of epizooty with high mortality rates among the wild birds on the coast of the Ubsu-Nur lake (Republic of Tyva, 51 degrees NL, 93 degrees EL, June 2006) revealed the etiological role of highly pathogenic avian influenza (HPAI) H5N1. Seven HPAI/H5N1 strains were isolated from the tracheal/cloacal swabs of clinically healthy, ill and recently dead great-crested grebes (Podiceps cristatus), cormorants (Phalacrocorax carbo), balt-coots (Fulica atra), and common terns (Sterna hirundo) collected on June 24, 2006, and incorporated to the RF State Collection of Viruses (with the July 3, 2006 priority). Full-length genome nucleotide sequences were incorporated to the GenBank (with the July 23, 2006 priority) (DQ852600-DQ852607). Comparative analysis of molecular genetic characteristics showed their belonging to the Qinghai-Siberian genotype. The strains were sensitive to rimantadine.

Animals↗
PubMedDate not supplied

[The population structure of the African swine fever virus based on the quantitative hemadsorption trait].

Subpopulation composition of 8 ASFV isolates and variants differing in virulence was evaluated comparatively by their haemadsorption capacity. The "quantitative haemadsorption marker" was shown to be useful for characterization of the strains, virus population phenotypic heterogeneity and structure. The marker expression was found to correlate with virulence: attenuated variants had low haemadsorption and more subpopulation components with that shift, and vice versa.

African Swine Fever Virus↗