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Biomedical subjects

N A Zhavoronkov

Publications and source records attributed to N A Zhavoronkov.

9 recordsLinked to original sources
PubMed1997

[Role of membrane protectors and antioxidants in the process of perfusion and preservation of donor lungs].

Comparative study of the effect of four perfusion and preservation solutions on lung function, conducted in experiments on 69 inbred dogs, revealed the following regular features. Euro-Collins and electrolyte solutions cause a marked increase of the capillary-hydrostatic pressure, a significant decrease of colloido-osmotic pressure of the plasma, and, as a result, reduction of the ient between them. This is manifested by edema of the lungs. The use of LPD solution is attended by moderate edema of the lungs in moderately increased capillary hydrostatic pressure and mildly reduced colloido-osmotic pressure of the plasma. Perfusion and preservation of the lungs with the LPD solution, containing membrane protectors and antioxidants, for 12 hours is marked by practically unchanged indices of capillary-hydrostatic pressure, plasma coloido-osmotic pressure, and the gradient between them. Edema of the lungs does not develop in this case.

Animals↗
PubMed1991

[Morphologic lung changes in a female patient with Zivert-Kartagener's syndrome].

Histologic and ultrastructural pulmonary changes in a female with a classical Zivert-Kartagener's syndrome are described. Congenital anomalies of the columnar epithelium brushes as well as defects acquired in the process of inflammation (decreased number and various length of bruches with their orientation disturbances, additional doublets and the lack of basal bodies) were revealed at transmission and scanning microscopy level. Follicular bronchiectasis, chronic pneumonia, dystelectasies, emphysema result from the mucociliary clearance disturbance and are of an acquired nature.

Adult↗
PubMed1988

[Morphological evaluation of reconstructive operations on the bronchi using a microsurgical technic in an experiment].

Morphological study of bronchial anastomoses repair made with or without microsurgical techniques has been performed in 30 mongrel dogs. Comparative analysis of bronchoscopy, microscopy and scanning electronic microscopy data shows earlier epithelialization, more regular conjunction of bronchial tube and less marked inflammation in anastomosis made with microsurgical techniques. The fact may be explained by a less pronounced traumatization of bronchial tissues with microinstruments and also by tight suture of mucosal layer which creates favourable conditions for repair of anastomosis per primam.

Anastomosis, Surgical↗
PubMedDate not supplied

[Microsurgical sutures of the trachea and bronchi (experimental study)].

A method for the formation of tracheal and bronchial anastomoses with a two-row suture by means of microsurgical techniques was elaborated in experiments on 52 mongrel dogs. In the control series the bronchial anastomosis was created with interrupted sutures passed through all the coats of the bronchial wall. Morphological study of the reparative processes in the tracheal and bronchial anastomoses showed that healing of the anastomosis formed by means of microsurgical techniques occurred sooner and with a lesser inflammatory reaction than healing of the communication in the control series. This is explained by the fact that the microsurgical suture of the tracheal and bronchial mucosa ensures adequate approximation of the margins of the anastomosis and reliable air-tightness and promotes healing by first intention.

Animals↗
PubMedDate not supplied

[The quality of the preservation of lungs using different solutions (an experimental study)].

Effects of different perfusion conditions and storage of isolated dog lungs on the process of edema development were studied. Sixty-nine mongrel dogs were used in the study. In case of a 15 min perfusion via the pulmonary artery and 12 h storage lung condition depended mainly on the type of solution and addition of protective drugs to this solution. Euro-Collins and low-potassium electrolytic solution markedly increased capillary hydrostatic pressure and drastically reduced plasma colloid-osmotic pressure. As a result filtration coefficient increased and as soon as an hour after reperfusion onset a marked pulmonary edema developed. Use of LPD solution without drugs added for 2.5 h reperfusion was associated with a moderate increase of capillary hydrostatic pressure and negligible decrease of plasma colloid-osmotic pressure. If the reperfusion were longer plasma colloid-osmotic pressure reduced, this leading to development of moderate pulmonary edema. A 15 min lung perfusion via the pulmonary artery and 12 h storage at 1 degree C in LPD solution with membrane protectors and antioxidants was associated with virtually unchanged capillary hydrostatic pressure, plasma colloid-osmotic pressure, and filtration coefficient and, hence, no pulmonary edema.

Animals↗