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Biomedical subjects

N Abeles

Publications and source records attributed to N Abeles.

8 recordsLinked to original sources
PubMed2002

Nicotine's effect on neural and cognitive functioning in an aging population.

Tobacco is a dangerous and addictive drug being consumed by more than 13% of Americans over the age of 65. Of the people in this cohort it has been estimated that between 24% and 85% experience some form of age related cognitive decline and 30-50% of the population will be diagnosed with Alzheimer's disease by the age of 85. Recent advances in nicotine research have pointed to a number of cognitive and neurological benefits that have been linked to the ingestion of nicotine. These discoveries hold the potential of new drugs and therapies that retain and improve upon nicotine's benefits while eliminating the negative impact that both nicotine and tobacco possess. This article examines cognitive decline in the elderly and looks at nicotine's potential role in ameliorating this decline. In service to this, the neurological and cognitive actions of nicotine are reviewed, as are theories on the neurological degeneration associated with Alzheimer's disease (AD).

Aged↗
PubMed2002

Decline in verbal memory performance with advancing age: the role of frontal lobe functioning.

This study investigated the relationship between measures of frontal lobe functioning (FLF) and verbal memory performance among healthy, community-dwelling older adults (60-85 years old). All were administered measures of FLF, attention, verbal memory, and depression. After controlling for the effects of attention and depression, FLF accounted for significant amounts of the variance in verbal memory scores. Age related to the FLF measure according to the level of organization of verbal material to be recalled. Frontal lobe functioning and performance on an attention measure explained the greatest amount of the variance in the recall of unorganized verbal material, whereas age and attention abilities were the best predictors of the recall of organized verbal material. The data indicate a central role of frontal dysfunction in understanding age-related memory loss.

Activities of Daily Living↗
PubMed1999

End of life decisions and assisted suicide.

End of life decisions and hastened suicide are discussed following the passage of the Death With Dignity Act in Oregon in 1994. Case examples are presented including a vignette highlighting ethical issues. Arguments for and against suicide prevention are presented, and the pros and cons of rational suicide are detailed. The experience with physician-assisted suicide in the Netherlands is briefly presented, and it is noted that in rare cases physician-assisted suicide is permitted for individuals in the Netherlands suffering primarily from mental disorders. The role of the mental health professional in end of life decisions is discussed along with a description of the proposed work of the recently established American Psychological Association working group on assisted suicide and end of life decisions.

Decision Making↗
PubMed1996

Age differences in retrieval: further support for the resource-reduction hypothesis.

Age differences in processing resources seem salient to age-related declines in secondary (or "recent") memory. Community-dwelling adults (N = 90, ages 30-80) completed 4 memory tests: Wechsler Memory Scale-Revised (WMS-R) Logical Memory (LM), Cowboy Story (CS), WMS-R Visual Reproductions (VR), and Extended Complex Figure Test (ECFT; Fastenau, in press). Two space-capacity measures (WMS-R Digit Span and Visual Memory Span) and 4 processing speed measures (cancellation and mental-tracking tasks) assessed processing resources. A statistical control procedure was used to isolate retrieval efficiency and measures contributions of age and processing resources to retrieval. A negative relationship between age and retrieval efficiency emerged on all measures (p < .05). The age effect was reduced 60% on LM and CS when processing resources were controlled, eliminated for VR, and unchanged on ECFT. It is possible that visual-spatial retrieval requires fewer processing resources than does verbal retrieval.

Adult↗