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Biomedical subjects

N Afifi

Publications and source records attributed to N Afifi.

13 recordsLinked to original sources
PubMed1996

Effect of cold storage on the haemostatic cascade systems.

This study dealt with the effect of citrate phosphate dextrose adenine (CPDA) whole blood stored at 4 degrees C for 5 weeks and fresh frozen plasma at -30 degrees C for 12 months on coagulation, fibrinolytic and kallikrein system activation. Stored whole blood showed a significant decrease in ATIII activity by the second week with a significant decrease in thrombin-antithrombin complex by the fourth week. alpha 2-antiplasmin and plasminogen decreased significantly by the first and second week, respectively, accompanied by a significant increase in D-dimer level by the fourth week. A significant decrease in C1-inhibitor activity occurred by the first week associated with a significant increase in kallikrein activity by the third week. However, all measured parameters were minimally affected in fresh frozen plasma. Therefore, fresh frozen plasma supplemented with packed RBCs are preferred to whole blood stored over 3 weeks especially in patients with proteolytic enzyme system activation.

Blood↗
PubMed1980

Altered cell mediated immunity in atrophic rhinitis.

Cellular immunity was studied in patients with atrophic rhinitis using the in vitro leucocyte migration and the spontaneous rosette tests. Cellular hypersensitivity to crude nasal homogenate was detected in 90 per cent of our cases as shown by inhibition of the leucocyte migration. The spontaneous rosette test showed a reduction in the number of T-cells forming rosettes which reflects a decrease in the absolute number of T-lymphocytes. This altered cellular reactivity or loss of tolerance to nasal tissues may be precipitated primarily by virus infection, malnutrition and/or immuno-deficiency which trigger a destructive auto-immune process with the release of antigen(s) of nasal mucosa into the circulation.

Adolescent↗
PubMed1975

Gm and Inv allotypes in French Guiana Indians.

Data from 302 individuals belonging to three populations of French Guiana Indians are reported. All the phenotypes except two can be explained by three haplotypes: Gm1,21, Gm1,2,21 and Gm1,10,11,25. The gene frequencies found in the present study are generally in accordance with those previously described among other South American Indians. For the Inv1,2 gene a high value has been found for the Wayanas and the Oyampis, but a difference appears for the Emerillons who possess a low frequency.

Blood Group Antigens↗
PubMedDate not supplied

Human leukocyte antigen in genodermatosis.

Tissue typing performed on the lymphocytes of 41 patients, including: 23 patients with ichthyosis (15 of autosomal dominant and 8 of the x-linked variety; 8 patients with tuberous sclerosis (epiloia); and 10 patients with acrodermatitis enteropathica (AEP). In addition, tissue typing was performed for a control group of 80 healthy unrelated subjects of the same ethnic origin as the patients. A significant increase of A2 antigen or its crossreacting antigen A28 was detected among the three diseases studied. A significant increase of HLA-A2 antigen was found in autosomal dominant ichthyosis, while the x-linked variety showed significant association with HLA-Cw2. A significant association with HLA-A28 antigen was noticed in both epiloia and AEP. The suggested mechanisms of such association may be referred to as incidental genetic linkage with mutants causing disease or deficiency.

Acrodermatitis↗