PubMed Health⌕ Search

Biomedical subjects

N Altinörs

Publications and source records attributed to N Altinörs.

33 records · Page 2Linked to original sources
PubMed1992

Regulation of M2-type pyruvate kinase from human meningioma by allosteric effectors fructose 1,6 diphosphate and L-alanine.

In the present study the mechanism of action of M2-type pyruvate kinase from human meningioma in the simultaneous presence of fructose 1,6 diphosphate and L-alanine was investigated. Purified pyruvate kinase from human meningioma was allosterically inhibited by L-alanine with respect to substrates phosphoenolpyruvate and ADP. The inhibitory effects of L-alanine was partially removed by fructose 1,6 diphosphate. The purified enzyme was slightly susceptible to ATP inhibition.

Adenosine Diphosphate↗
PubMed1991

Rare causes of hemifacial spasm. Report of two cases.

Two patients are presented whose sole symptom was hemifacial spasm. Cerebellar arachnoid cyst was diagnosed in one patient who was treated effectively by removal of the cyst and decompression of the facial nerve. The second patient had an AVM of the posterior fossa. Surgery was withheld in this case.

Adult↗
PubMed1989

Spinal extradural metastasis from a medulloblastoma.

Medulloblastoma metastasising extraxially is a rare entity. The mechanisms that cause such spread are not fully understood. We present a patient who developed a low thoracic metastasis three years after surgical removal of a posterior fossa medulloblastoma. A spinal metastasis penetrated the dura, thus becoming extradural and from this tumour a completely extradural lumbal metastasis developed. Simultaneous local recurrences of systemic metastases were not noted.

Adolescent↗
PubMed1985

Scalp meningioma: case report.

The authors report a case of scalp meningioma. The mass was removed totally, and all of the following neuroradiological studies proved the absence of an intracranial meningioma.

Adult↗
PubMedDate not supplied

CT findings and surgical treatment of double intracranial echinococcal cysts.

The authors present a young male patient with two intracranial lesions, one in the left occipital lobe, the other in the left temporal lobe. These masses were totally removed and both proved to be alveolar hydatid cysts. Surgery for a large hepatic mass, diagnosed after the first craniotomy, was refused by the patient.

Adult↗
PubMedDate not supplied

MRI findings and encouraging fluconazole treatment results of intracranial Cladosporium trichoides infection.

The authors report on a 31-year-old male patient harboring multiple intracranial mass lesions which proved histologically to be due to infection with Cladosporium trichoides upon removal of one of the lesions. Aggressive antifungal chemotherapy with fluconazole (400 mg/d for 3 months) in combination with surgery resulted in good clinical and radiologic outcome which prompted us to report this case.

Adult↗
PubMedDate not supplied

Management of problematic intracranial hydatid cysts.

The authors report four patients with intracranial hydatic cysts. One patient had a pontine lesion which was punctured and aspirated and the cyst wall removed with a satisfactory outcome. The second patient had multiple cysts which was comparable to meningeomatosis. She had a rapidly deteriorating neurologic condition which proved to be fatal in spite of two consecutive surgical interventions. The third patient had nine lesions although only six were evident on the MRI. All of the cysts were removed, while two cysts ruptured. Multiple paracardial cysts of this patient were surgically removed shortly after the craniotomy. The last patient, again with multiple intracranial hydatid cysts had safe, total removal of all cysts. The first postoperative control CT raised the possibility of recurrence since the CT was highly suggestive of a hydatid cyst. However, this was not confirmed in the follow-up CT examination. Problems and the solutions of management are discussed.

Adult↗
PubMedDate not supplied

Cerebral Dermabacter hominis abscess.

Dermabacter species are commonly isolated from the skin and other body sites but rarely show pathogenicity in humans. A case of Dermabacter hominis cerebral abscess is reported which presented as a contrast-enhancing intracranial mass in a renal transplant patient.

Adult↗
PubMedDate not supplied

Correlation between histological grade and MIB-1 and p53 immunoreactivity in meningiomas.

OBJECTIVE: Meningiomas for the most part are slow-growing benign tumors, but complete removal can be difficult and recurrence is an issue. The aim of this study was to re-evaluate tumors diagnosed as meningioma previously in our hospital, according to the latest World Health Organization classification. We also examined the relationships among parameters such as brain invasion, histological grade and Ki-67 and p53 expression in these tumors. MATERIALS AND METHODS: Meningioma biopsy specimens numbering 60 (48 grade I, 11 grade II, and 1 grade III tumors) were examined immunohistochemically using monoclonal antibodies for Ki-67 (MIB-1) and p53 protein. The MIB-1 labeling index (LI) for each tumor was calculated as a percentage based on the number of stained cells per total cells counted. The level of p53 expression in each sample was semiquantatively evaluated as < 1%, 1 - 10%, 10 - 70%, or > 70%. Any value > 1% was accepted as presence of p53 expression. RESULTS: Of the 60 meningiomas, 7 (11.7%) exhibited brain invasion. The mean MIB-1 LI values for the grade I and grade II tumors were 1.1% and 2.3%, respectively. The corresponding levels of p53 protein expression in these groups were 54.1% and 72.7%. The MIB-1 LI and the level of p53 expression in the one grade III meningioma were 6.7% and 10 - 70%, respectively. Histological grade was significantly correlated with MIB-1 LI and with p53 expression (p < 0.01 for both). Brain invasion was not correlated with histological grade, MIB-1 LI, or p53 expression. CONCLUSION: The results indicate that MIB-1 LI and p53 protein expression are good indicators of histological grade in meningioma and may be particularly valuable for distinguishing borderline atypical meningiomas. The number of cases was limited, but the findings also suggest that brain invasion is a prognostic parameter independent of grade, MIB-1 LI and p53 expression.

Adult↗