PubMed Health⌕ Search

Biomedical subjects

N Amarasekera

Publications and source records attributed to N Amarasekera.

10 recordsLinked to original sources
PubMed1996

Brain abscess caused by Nocardia asteroides.

A case of Nocardia brain abscess in a patient receiving immunosuppressives is reported. The diagnosis was made by aspiration and culture of pus from the abscess. This is the first documented case of Nocardia brain abscess in Sri Lanka.

Adult↗
PubMed1995

Idiopathic bronchiolitis obliterans.

We describe a case of idiopathic bronchiolitis obiterans, an uncommon cause of small airway disease. A restrictive ventilatory defect and a favourable response to corticosteroids are characteristic of this disease. This condition has not been documented previously in Sri Lanka.

Adult↗
PubMed1994

Bite of a sea snake (Hydrophis spiralis): a case report from Sri Lanka.

A rare case of sea-snake bite resulting in envenoming is reported. Comparison is made with clinical features of sea-snake envenoming as described in the literature. Some of the unusual features observed in our patient were the occurrence of pain at the site of the bite, regional lymph node enlargement and absence of muscle pain and tenderness. Polyvalent land-snake antivenom was used in the management of this patient since specific antivenom against sea-snake envenoming is not available in Sri Lanka. There was some improvement in neurological signs after the start of antivenom treatment. This is the first authenticated case of sea-snake envenoming in Sri Lanka.

Adult↗
PubMed1994

Salmonella typhi endocarditis.

We report the case history of a patient with Salmonella typhi endocarditis. Bacteriological diagnosis was made by bone marrow culture when isolation from blood was unsuccessful. This is the first case of S typhi endocarditis to be documented in Sri Lanka.

Adult↗
PubMedDate not supplied

Efficacy of single dose combinations of albendazole, ivermectin and diethylcarbamazine for the treatment of bancroftian filariasis.

In a 'blind' trial on 50 male asymptomatic microfilaraemic subjects with Wuchereria bancrofti infection, the safety, tolerability and filaricidal efficacy of a single dose of albendazole (alb) 600 mg alone or in combination with ivermectin (iver) 400 micrograms/kg or diethylcarbamazine citrate (DEC) 6 mg/kg was compared with a single dose of the combination DEC 6 mg/kg and iver 400 micrograms/kg over a period of 15 months after treatment. All but one subject, with 67 microfilariae (mf)/mL, had pre-treatment counts > 100 mf/mL. All 4 treatments significantly reduced mf counts, but alb/iver was the most effective regimen for clearing mf from night blood: 9 of 13 subjects (69%) were amicrofilaraemic by membrane filtration 15 months after treatment compared to one of 12 (8%), 3 of 11 (27%), and 3 of 10 (30%) in the groups treated with alb, alb/DEC, and DEC/iver, respectively. Filarial antigen tests suggested that all 4 treatments had significant activity against adult W. bancrofti; alb/DEC had the greatest activity according to this test, with antigen levels decreasing by 77% 15 months after therapy. All 4 regimens were well tolerated and clinically safe, although mild, self-limited systemic reactions were observed in all treatment groups. These results suggest that alb/iver is a safe and effective single dose regimen for suppression of microfilaraemia in bancroftian filariasis that could be considered for control programmes. Additional benefits of this combination are its potent, broad spectrum activity against intestinal helminths and potential relative safety in areas of Africa where DEC cannot be used for filariasis control because of co-endemicity with onchocerciasis or loiasis.

Adolescent↗