PubMed Health⌕ Search

Biomedical subjects

N Andreescu

Publications and source records attributed to N Andreescu.

At least 19 recordsLinked to original sources
PubMed1984

May human leptospirosis develop as a chronic infection?

In connection with some rather uncommon cases, the authors asked themselves whether leptospirosis may also develop as a chronic infection. To answer this question, we took into consideration four of the most representative investigated cases encountered during the last 22 years. In conclusion, it appears that in some circumstances, human leptospirosis could present itself as a chronic disease.

Adult↗
PubMedDate not supplied

Leptospirotic etiology in pulmonary and upper respiratory tract pathology.

A number of 3,200 febrile patients who presented upon admission to hospital primary pulmonary or upper respiratory tract impairment either as single forms of manifestation or associated to other syndromes were tested. The cases were screened by the rapid slide agglutination reaction with heat inactivated Patoc antigen and leptospirotic etiology was confirmed by the ultramicroscopic agglutination reaction with 18 live circulating pathogenic antigens. 64 leptospirosis cases with pulmonary impairment were confirmed and in 52 cases the upper respiratory tract was involved. Particular aspects of leptospirosis with pulmonary impairment: 71.8% of cases had a clinical diagnosis of interstitial pneumonia; 89% of cases presented important chest x-ray modifications; in an approximately equal number of cases the pulmonary involvement was the single manifestation or was associated with other syndromes; icterohaemorrhagiae, wolffi and pomona were the frequently encountered infecting serotypes. Particular aspects for leptospirosis involving the upper respiratory tract: 84.6% of cases had a clinical diagnosis of acute rhino-pharyngotracheitis; in 86.5% of cases the upper respiratory tract impairment was the single feature; the infecting serotypes were in decreasing order of frequency as follows: icterohaemorrhagiae, pomona, wolffi, canicola, grippotyphosa.

Adolescent↗
PubMedDate not supplied

A new prepatory method of thermically inactivated Leptospira Patoc antigen for rapid slide agglutination used as serosurvey test for human leptospiroses.

830 sera from leptospirosis-suspect patients and 133 sera from investigations were analysed by the new test--rapid slide agglutination with Patoc antigen, inactivated at 60 degrees C for 15 minutes, in parallel with two standard tests--CFT with merthiolated Patoc antigen and MAR with 17-23 live pathogenic antigens. The new serotest proved efficient for selecting the cases of disease or leptospira infection, acute or recent form, not older than 2 years, both by its sensitivity and specificity and also by its rapid and economical character. In the present paper, the technology of preparation and control of Patoc antigen, inactivated at 60 degrees C for 15 minutes, is described.

Agglutination Tests↗