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Biomedical subjects

N Arumugasamy

Publications and source records attributed to N Arumugasamy.

At least 19 recordsLinked to original sources
PubMed1985

Concomitant cerebral and breast cryptococcosis.

A patient with a solitary intracranial cryptococcoma of the occipital lobe of the brain and a concomitant granuloma of similar aetiology in the breast is reported. Despite resistance of the causative fungus to 5-fluorocytosine in vitro, the patient responded well to radical excisional surgery and therapy with 5-fluorocytosine.

Adolescent↗
PubMed1985

Intracerebral cryptococcomas.

Cerebral cryptococcomas are not unusual and occurred in 7.8% of our cases of cryptococcal meningitis. This warrants a careful lookout for it if treatment is to be prompt and effective. CAT Scanning has proved to be an important adjunct in investigative exclusion of such instances. Although cerebrospinal fluid shunting proved to be of great importance in patients with demonstrable hydrocephalus, total surgical extirpation of the granuloma when demonstrated would appear to be essential, if cure is to be assured. 5-Fluorocytosine continues to be the drug of choice although recent indications of resistance to it are real. Modifications to antifungal chemotherapy will hence have to be judiciously made. Agglutination studies, besides typing, have indicated their usefulness in this regard, in the management of our cases.

Adolescent↗
PubMed1977

Tuberculous abscesses of the cervical spine with quadriparesis.

Four cases of tuberculosis of the cervical spine with quadriparesis either from subluxation, and/or compression of the spinal cord are described. Our surgical approach has been laminectomy with excision of abscess and cervical fusion. Pre and post operative cervical traction with Crutchfield tongs on Stryker beds was employed in three of the four cases. Excision of these abscesses and cervical fusion, following improvement of the nutritional status and adjunctive chemotherapy, can reverse paralysis in these patients. Three of our four patients recovered.

Adult↗
PubMed1976

Cerebral cryptococcosis in Malaysia.

Cryptococcal infection of the brain as encountered in a tropical country is reviewed. The meningitic form is not uncommon and there has been, in the last decade, an apparent, if not real, rise in incidence in Malaysia as in Singapore. Only exceptionally was there overt evidence of immunological deficiency. Hydrocephalus was present in about three-quarters of the patients with meningitis and shunts were employed readily. The presence of multiple small intracerebral cysts could be suspected clinically but treatment for this complication was ineffective. The antifungal agent used most frequently was 5-fluorocytosine. Resistance to this drug developed in about one patient in four. There is a need for further epidemiological studies and for a continuing search for new antifungal agents.

Adolescent↗