Biomedical subjects

N Attal

Publications and source records attributed to N Attal.

40 records · Page 3Linked to original sources

PubMed1989

Evidence for central phenomena participating in the changes of responses of ventrobasal thalamic neurons in arthritic rats.

In this study performed in the Freund's adjuvant-induced arthritic rat, a local injection of lidocaine in one hind paw strongly depressed the ventrobasal thalamic neuronal responses to mild stimulation of both ankles. In parallel, a behavioral study provided evidence for a bilateral hypoalgesia, tested by the vocalization threshold to paw pressure, after a unilateral anesthetic block. The involvement of central phenomena in the changes of neuronal responsivity described in this model of experimental pain is therefore suggested.

Action Potentials↗

PubMed1988

[Analgesic action of sodium diclofenac: behavioral and electrophysiological study in normal and polyarthritic rats].

In a behavioural study, the effects of intravenous diclofenac in a range of doses were determined by measuring vocalization thresholds to paw pressure in normal and Freund's adjuvant-induced arthritic rats. In normal rats, 6 and 9 mg/kg diclofenac produced an increase in vocalization thresholds (mean threshold values were respectively 135.67 +/- 3.30 per cent and 157.41 +/- 4.62 per cent of the control at 30 min; n = 9 for each group), no effect resulting with 3 mg/kg. In arthritic rats, 3, 6 and 9 mg/kg diclofenac induced a clear analgesic effect (mean threshold values being 172.22 +/- 4.26 per cent, 201.76 +/- 4.76 per cent and 222.33 +/- 5.10 per cent respectively of the control at 25 min, n = 9 for each group), no effect being observed with 1.5 mg/kg. An electrophysiological study performed on arthritic rats considered the effect of 6 mg/kg diclofenac upon the neuronal ventrobasal thalamic responses induced by mode-rate stimulation of an inflamed joint. The responses were depressed by about 50 per cent, 20 minutes after the injection. These results show that diclofenac displays a direct effect on pain processing; this effect is more potent in arthritic rats than in normal rats.

Animals↗

PubMed1988

Behavioural and electrophysiological evidence for an analgesic effect of a non-steroidal anti-inflammatory agent, sodium diclofenac.

The effects of various i.v. doses of diclofenac sodium (Voltaren, 1.5, 3, 6 and 9 mg/kg) were evaluated by measuring the vocalization threshold in response to paw pressure in normal and in Freund's adjuvant-induced arthritic rats. An electrophysiological study performed in parallel in arthritic rats considered the effects of 6 mg/kg i.v. diclofenac on ventrobasal thalamic neuronal responses driven by mild stimulation of an inflamed joint. In normal rats, 6 and 9 mg/kg i.v. diclofenac raised vocalization thresholds significantly (maximum vocalization thresholds were respectively 135.67 +/- 3.30% and 157.41 +/- 4.62% of the preinjection control at 30 min, n = 9 in each group), while no effect was observed with 3 mg/kg. In arthritic rats, i.v. doses of 3, 6 and 9 mg/kg diclofenac induced a clear analgesic effect (maximum vocalization thresholds were respectively 172.22 +/- 4.26, 201.78 +/- 4.76, 222.33 +/- 5.10% of the control at 25 min, n = 9 in each group), whereas a dose of 1.5 mg/kg i.v. did not raise the threshold. In arthritic rats, the VB neuronal responses were depressed by about 50% 20 min after an injection of 6 mg/kg i.v. diclofenac. These results clearly establish that diclofenac produces a dose-dependent analgesic effect, which is more potent in arthritic than in normal rats.

Action Potentials↗

PubMedDate not supplied

Double spinal dural arteriovenous fistulas: report of two cases.

We report two unusual cases of double spinal dural arteriovenous fistulas. Both patients had signs and symptoms commonly described in this condition, but selective angiography of the spinal cord demonstrated two separate dural arteriovenous fistulas with separate venous drainage for each fistula.

Angiography↗