Biomedical subjects
N B Ackerman
Publications and source records attributed to N B Ackerman.
The blood supply of experimental liver metastases. I. The distribution of hepatic artery and portal vein blood to "small" and "large" tumors.
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Clinical and experimental uses of radioisotopes in the diagnosis of cancer.
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Bone formation in the gastric mucosa following subtotal gastrectomy in rats.
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Preparation and screening of aminoacridines for induction of lung tumor fluorescence in rats.
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The increased uptake of quinacrine by tumors in experimental animals: measurements of tissue levels by fluorometric technique.
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Engineering problems in design and utilization of hyperbaric oxygenation equipment.
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An evaluation of gastric cytology: results of a nation-wide survey.
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The effect of hyperbaric oxygenation on the uptake of radioisotopes by tumors in rats.
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Comparisons of radiocolloid distribution following administration by portal vein and peripheral vein injections.
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Oxygen tensions in normal and ischemic tissues during hyperbaric therapy. Studies in rabbits.
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Scanning and irradiation of the liver with radioisotopes.
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Development of gastric cancer in experimental animals.
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Use of radioisotopic agents in the diagnosis of cancer.
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Massive ileostomy and colostomy hemorrhage from mucocutaneous varices in patients with coexisting cirrhosis.
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The acute effects of hematoporphyrin derivative photoradiation on tumor and liver capillary blood flow.
The acute effects of photoradiation after administering hematoporphyrin derivative (Hpd) on capillary blood flow were studied in intrahepatic tumors and normal liver. The tumors were solitary Walker carcinosarcomas implanted within the livers of Sprague-Dawley rats. Capillary flow was measured by a laser doppler monitor with its probe positioned over the tumor or over normal liver. Within a minute after intraportal Hpd injection (1.7 mg), capillary flow in the tumors began to decrease. Minimal levels of flow were maintained for as long as 15 minutes after Hpd injection with no observed recovery of flow back to control levels. Ratio of minimal flow/control flow averaged 0.36. Similar results were seen in studies on normal liver tissue. These studies demonstrate the extremely rapid vasoactive effects caused by photoradiation of Hpd. Vasoconstriction, vascular stasis and ischemia have proven to be important mechanisms in producing tumor cell destruction by photodynamic therapy.
Variations in intestinal lymphatic flow rates, and their possible significance in colon cancer surgery.
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Studies on the circulatory dynamics of intrahepatic tumor blood supply.
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