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Biomedical subjects

N B EDDY

Publications and source records attributed to N B EDDY.

At least 19 recordsLinked to original sources
PubMed1963

Tests for addiction (chronic intoxication) of morphine type.

A survey is presented of laboratory and clinical methods for the determination of addiction liability of substances with morphine-like effects. Since physical dependence is the outstanding pharmacological criterion of addiction of morphine type, the procedures for its qualitative and quantitative assessment are described in detail.

Humans↗
PubMed1957

Synthetic substances with morphine-like effect: clinical experience; potency, side-effects, addiction liability.

A review of effects in man of morphine-like drugs which have been brought under international narcotics control is presented in the form of individual monographs. These are based on controlled observations with quantitative data and significant reports of results obtained in medical practice. In a summarizing section, the drugs are compared with respect to effectiveness, side-effects and addiction liability. Morphine-like drugs of natural and synthetic origin now cover a wide range of potency (analgesic, antitussive), not necessarily paralleled by incidence of side-effects or addiction liability.

Analgesics, Opioid↗
PubMed1956

Synthetic substances with morphine-like effect; relationship between analgesic action and addiction liability, with a discussion of the chemical structure of addiction-producing substances.

For compounds of the morphine, morphinan, pethidine, hexamethyleneimine, methadone, and dithienylbutenylamine groups, the analgesic and physical-dependence-producing properties are compared. On the basis of a parellelism in intensity of these properties, conclusions are drawn regarding their interrelationship and the chemical features common to substances with morphine-like addiction liability.

Analgesics↗