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Biomedical subjects

N B Finter

Publications and source records attributed to N B Finter.

At least 37 records · Page 2Linked to original sources
PubMed1981

Interferon production by human lymphoblastoid cell lines of different origins.

150 lymphoblastoid cell lines derived from normal individuals or from subjects with various clinical conditions were induced to form interferon by treatment with Sendai virus. Irrespective of the status of the donor, most of the lines produced some interferon and 22 produced considerable amounts (more than 3000 international units/ml). Lines derived from infectious mononucleosis patients were good interferon producers while those from leukaemic donors were poor producers. The data suggest that the clinical conditions of the donor and the source of transforming virus may influence the quantity of interferon produced by a given cell line.

Cell Line↗
PubMed1978

Effects of adverse storage on live virus vaccines.

A vaccine stored strictly according to the manufacturer's instructions can be used with confidence up to the designated expiry date. However, problems with transport, refrigeration plant, or electricity supply may lead to the exposure of a vaccine under field conditions, and particularly in tropical countries, to high or fluctuating temperatures. We have therefore studied the stability of the standard formulations of our live yellow fever virus, poliovirus and rubella virus vaccines, when they were deliberately exposed to high temperatures, or to alternating cycles of high and low temperatures, intended to simulate such conditions. Our results suggest that with these vaccines, the consequences of adverse storage are not likely to be serious.

Cold Temperature↗
PubMed1977

The precision and comparative sensitivity of interferon assays.

Any interferon assay essentially measures the potency of unknown samples relative to each other or to a standard. The reliability of such measurements of relative potency, i.e. the precision of the assay, is a key feature of any method. In contrast, sensitivity is seldom a characteristic of great importance in an assay. Nevertheless, relatively high sensitivity can often be achieved quite readily by a suitable choice of cells and challenge virus.

Animals↗
PubMed1976

Optimal schedules for use of interferon in the corneas of rabbits with herpes simplex keratitis.

The 50% infectious dose of a preparation of herpes simplex virus was measured in eyes of rabbits by a multiple corneal inoculation method. One hour after inoculation of virus, one eye was treated with drops of human leukocyte interferon, and the other was treated with saline or with a different dose of interferon. Results from groups of three to four rabbits were combined for analysis. Treatment reduced the 50% infectious dose of virus in proportion to the concentration of interferon applied (within the range of 6.5 X 10(4)-1.3 X 10(6) units/ml) and not according to the total number of units instilled. Different treatment schedules were tried. Two applications of interferon each day were as effective as eight applications at intervals of 15 min or 1 hr. One application produced near-maximal antiviral effects for 18-24 hr. Thus, in human herpetic keratitis, a single daily application of the most concentrated available preparation of human interferon might be the most efficient schedule of treatment.

Animals↗
PubMed1976

Long term storage studies with a new stabilised formulation of yellow fever virus vaccine.

A new formulation of yellow fever virus vaccine incorporating a stabiliser has been prepared which is very much more stable than conventional unstabilised vaccines. This vaccine has a half life of 2-4 years at 4 degrees C, 9 months at 20 degrees C and 10 days at 37 degrees C. Its greater stability should have considerable advantages, especially when it is used in tropical countries.

Drug Stability↗