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Biomedical subjects

N B Man'kovskiĭ

Publications and source records attributed to N B Man'kovskiĭ.

At least 19 recordsLinked to original sources
PubMed1994

[Serotonin antibodies and their possible role in parkinsonism].

Serotonin antibodies (SAb) were found in the blood sera of middle-aged and elderly parkinsonian patients. The incidence of Sab in young and middle-aged healthy subjects was less, but increasing with age. Injected into the rabbit caudate nuclei, Sab suppressed the main pathogenetic mechanism of parkinsonian syndrome, the generator of pathologically enhanced excitation (GPEE) and parkinsonian symptoms induced by the MPP injection into substantia nigra. The intracaudate injection of serotonin enhanced GPEE activity and parkinsonian syndrome. The role of serotoninergic system and Sab in parkinsonism is discussed.

1-Methyl-4-phenylpyridinium↗
PubMed1993

[Dopamine antibodies in parkinsonism patients and their possible role in the pathogenesis of the parkinsonian syndrome].

Dopamine antibodies (DAb) were found in the blood serum of parkinsonian patients, middle-aged and elderly, but not young. There was a correlation between the DAb incidence and dominant symptom in the middle-aged and elderly patients and between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (the generator of pathologically enhanced excitation-GPEE) in this brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity and tremor). This effect was more expressed in the elderly rats compared with the young animals. The DAb role in the Parkinson's syndrome pathogenesis and in L-DOPA therapeutic tolerance formation is discussed.

Adult↗
PubMed1992

[Neurogeriatrics--a new chapter in clinical neuropathology].

An analysis is presented of age-related changes of the nervous system in the course of aging and their role in the development and course of age-dependent diseases, primarily, atherosclerosis, arterial hypertension, parkinsonism, osteochondrosis etc. in the elderly and old. Practical physicians have to pay attention to the peculiarities of clinical symptomatology, diagnosis, treatment and secondary prophylaxis of nervous system diseases in the elderly and old.

Aged↗
PubMed1991

[Dopamine antibodies in the pathogenesis of parkinsonism].

L-DOPA and dopamine (DA) binding antibodies were found in the blood serum of Parkinsonian patients and middle-aged and elderly normal persons. DA-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (generator of pathologically enhanced excitation) in these brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity, tremor). The serum gamma-globulins of Parkinsonian patients without Da-antibodies caused less pronounced EEG disturbances. Parkinsonian symptoms developed rarely and were shorter and less pronounced compared with the DA-antibody effect. The DA binding antibodies role in Parkinson's syndrome pathogenesis and is L-DOPA therapeutic tolerance formation was discussed.

Adult↗
PubMed1990

[Age-related features of the functional state of the brain in patients with circulatory encephalopathy].

Complex clinico-physiological examinations was performed in 300 patients of middle and old ages with early and pronounced dyscirculatory encephalopathy of atherosclerotic and, in most cases, hypertensive etiologies. The cerebral hemodynamics was found to be relatively independent of the central one in patients with early atherosclerotic encephalopathy; the level of the systemic circulation and that of the median regional cerebral flow were found to correlate in early and advanced hypertensive encephalopathy cases. The cerebral function was shown to be more associated with the cerebral flow in the early encephalopathy in elderly patients than in middle-aged ones. The individual and personal traits of the patients were largely related to the disease stage rather than to the predominant etiological factor.

Adult↗
PubMed1989

[Initial dyscirculatory encephalopathy in middle-aged and elderly patients (problems of early diagnosis and therapy)].

Combined clinicophysiological investigation was performed in IDE (195 patients) in order to assess the degree of cerebral circulation disorders and their impact on the levels of brain functional activity. The informative values of several quantitative indices of brain hemodynamics and neurodynamics were assessed with respect to the patients' age. Single administration and full course of cavinton and sermion (nicergoline) were effective as judged by cerebral circulation studies (133Xe clearance), brain bioelectric activity (EEG frequency integration analysis, visual evoked potentials). In senile patients, the effect of i.v. sermion administration was dose-dependent.

Aged↗
PubMed1989

[Sermion treatment of middle-aged and elderly patients with initial atherosclerotic encephalopathy].

The authors report results of a clinico-physiological study of the efficacy of a vasoactive agent sermion in patients with initial atherosclerotic encephalopathy indicating a positive effect of course treatment with this agent on the main clinical manifestations of the disease, pulse blood filling, bioelectric activity of the brain, psychomotor rate, mental working capacity, mnemonic function. Considering the established age-related differences in the efficacy of the agent, it is expedient to recommend sermion for long-term employment in the elderly. One should be cautious in instituting the drug in persons suffering of raised intraocular pressure.

Aged↗
PubMed1988

[Clinical characteristics of the macro- and microcirculation of patients with initial disordered-circulatory arteriosclerotic and hypertensive encephalopathy at different ages].

The article presents clinico-hemodynamic characteristics of 81 patients with initial disordered-circulatory atherosclerotic encephalopathy (33 aged 45-59 years and 48 aged 60-74 years) and of 65 patients with hypertensive encephalopathy (32 aged 45-59 years and 33 aged 60-74 years). Fifty-six normal subjects served as controls. The findings confirm the role of abnormalities at various functional levels of the circulatory system in the pathogenesis of cerebral vascular insufficiency at early stages of the disease.

Aged↗
PubMed1987

[State of cerebral and systemic blood circulation in patients with the initial manifestations of circulatory encephalopathy].

Parameters of the cerebral and systemic circulation were studied with the help of rheoencephalography in 119 patients with initial circulatory encephalopathy secondary to atherosclerosis (50 patients aged 45 to 59 years; 69, 60 to 74 years). Fifty-six healthy subjects served as a control group. The data obtained confirm the development of combined cardio-cerebrovascular insufficiency already at the initial stage of the disease and indicate the necessity of a comprehensive approach to the assessment of the function of two circulatory systems at an early stage of cerebrovascular pathology.

Adult↗