Biomedical subjects
N B Thomas
Publications and source records attributed to N B Thomas.
Conservative management of a patient with bilateral renal abscesses.
We present the case of a patient with no pre-existing systemic or renal disease who developed multiple, bilateral renal abscesses caused by infection with Escherichia coli. In view of the diffuse nature of his lesions the patient was not a candidate for percutaneous drainage or surgery. He made a full recovery following conservative antibiotic therapy.
Intrasplenic metastases from carcinoma of the ovary.
Intrasplenic metastases are an uncommon manifestation of malignant disease. The relative paucity of splenic metastases is thought to be due to the properties of the spleen as an organ of immune surveillance. We report five cases of splenic metastases from carcinoma of the ovary demonstrated by CT scanning and ultrasound examination. In this series, splenic metastases were associated with bulk disease and more anaplastic tumours. Increased availability of magnetic resonance imaging may improve the recognition of splenic metastases.
Xanthogranulomatous pyelonephritis in childhood.
A case of multifocal xanthogranulomatous pyelonephritis (XPN) in childhood diagnosed by ultrasound, computed tomography and needle biopsy is described. Following antibiotic therapy, ultrasound and a DMSA renal scintiscan showed no discernible scarring and restoration of function. This has not been previously described.
Unilobar enlargement of normal thymus gland causing mass effect.
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Automated external defibrillator-pacemaker.
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Selective splenic arteriography for interleukin-2 administration: radiologic complications from the initial 113 procedures.
A retrospective analysis was performed of the safety and efficacy of selective splenic artery catheterization for infusion of the immunotherapeutic agent interleukin-2 (IL-2). Fifty-one patients with metastatic melanoma had 103 successful catheterizations out of 113 attempts (91%). In nine patients preferential contrast flow was obtained into the splenic artery. When satisfactorily placed, the catheter position remained stable during the period of infusion in 98% of examinations. The incidence of major arteriographic complications was 4.5% and of minor complications 8.9%. The main problems encountered were thrombosis (3.6%) or persistent bleeding/hematoma formation (2.7%), in a patient population at high risk of malignant coagulopathy. Subintimal contrast injection occurred in five examinations (4.5%).