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Biomedical subjects

N Böhm

Publications and source records attributed to N Böhm.

At least 73 records · Page 4Linked to original sources
PubMed1980

Solitary rhabdomyoma of the heart. Clinically silent case with sudden, unexpected death in an 11-month-old boy.

We report a case of cardiac rhabdomyoma leading to sudden, unexpected death in an 11-month-old child. Autopsy disclosed a firm nodular tumor located in the anterior part of the interventricular septum and anterior wall of the left chamber. The tumor bulged into the cavity of the ventricle and caused appreciable narrowing of the outflow tract. Histologically, the typical "spider cells" characteristic for cardiac rhabdomyoma could be found. Sections cut from alcohol-fixed tissues and stained in water-free PAS showed that these cells contained massive amounts of diastase-digestible PAS-positive material, presumably glycogen. No evidence of tuberous sclerosis was detected. Sudden death was attributed to cardiac arrest due to irritation of the conducting system by the tumor.

Autopsy↗
PubMed1980

Adenocarcinoma of the appendix penetrating the bladder.

We report a case of a mucous papillary tumor in the bladder. Initial treatment was transurethral resection but open partial bladder resection became necessary. Operation revealed an appendix tumor penetrating the bladder. Histologically, it was primary adenocarcinoma of the appendix.

Adenocarcinoma, Papillary↗
PubMed1980

[Haemodynamics in congenital pulmonary lymphangiectasis (author's transl)].

Respiratory insufficiency is the clinical principal sign of cystic pulmonary lymphangiectasis. Clarification of cardiovascular morphology and haemodynamics is the basic prerequisite for the classification and therapy of the disease pattern. The prognosis is unfavourable if it is found that the pulmonary circulation does not flow through the lungs, reaching instead the systemic circulation via the persisting ductus arteriosus. The histopathological findings as well as the results of dissection of the cardiovascular system clarify the question as to the pathogenesis of this disease and allow subdivision of the disease into a primary and a secondary manifestation of cystic pulmonary lymphangiectasis.

Ductus Arteriosus, Patent↗
PubMed1980

Partial monosomy 22pter leads to q11 in a newborn with the clinical features of trisomy 13 syndrome.

In a female newborn with the clinical and postmortem findings of Pätau's syndrome no trisomy 13 could be found by chromosomal investigation. Rather, the karyotype 45,XX,-11,-22,+(11;22) (p15;q11) was ascertained by GTG-,RFA-and TFA-banding. The long arm of one chromosome 22 is translocated upon the short arm of one chromosome 11, and the remaining part of the derivative chromosome 22 is lost. The child therefore is monosomic for 22pter leads to q11 and probably for the telomeric region of 11p15. Since both parents possess normal karyotypes, it is a de novo translocation. The case in point illustrates that the more correlation of a given phenotype to a specific karyotype is not possible in all cases.

Chromosomes, Human, 13-15↗
PubMed1980

[Autotransplantation of spleen tissue after traumatic spleen rupture (traumatic splenosis). A report of 4 cases].

Report on 4 cases of traumatic splenosis (autotransplantation of splenic tissues) which were diagnosed 1 to 15 years after traumatic spleen rupture in childhood or adolescence. In 3 of the 4 cases traumatic splenosis was detected casually, the other case was misinterpreted during laparoscopy as endometriosis. Histologically the autotransplants reveal functional red and white splenic pulp. This may be significant for hematologic diseases. Although clinical signs are often lacking or noncharacteristic, knowledge of traumatic splenosis is important for surgeons, internists (laparoscopy!), gynecologists, and pathologists, because splenic autotransplantants are often misinterpreted as accessory spleens, hemangiomas, endometriosis or peritoneal metastases of melanoma.

Abdominal Neoplasms↗
PubMed1980

[Congenital defects of the diaphragm in siblings. Two case reports (author's transl)].

In two different families each time two siblings head a congenital defect of the diaphragm, in 3 cases of the posterolateral type, in 1 case an almost complete aplasia of the diaphragm. Usually, the occurrence of defects of the diaphragm is sporadic. However, familial occurrence has been reported in 15 cases. Multifactorial inheritance is most likely the explanation for this. With this hypothesis a risk of 2% can be calculated for the recurrence of this malformation in a family with already one affected child.

Diaphragm↗
PubMed1980

[New angles of view in cineangiography of congenital heart disease (author's transl)].

Axial oblique views were performed during cineangiography of congenital heart disease on patients of a paediatric cardiological unit for a period of two years. The resulting angle-patterns are shown in a synoptical review, and indications for angiographic demonstration of morphological conditions in congenital heart disease are discussed. In comparison with the literature to date, this is the first report of experience with a biplane synchronised "C" arm cineangiographic system.

Child↗
PubMed1979

[Leiomyoblastoma (epithelioid leiomyoma) of the stomach: a pathomorphological and retrospective study of 6 cases (author's transl)].

Gastric leiomyoblastoma is a well defined mesenchymal tumor originating from the smooth muscle tissue (tunica propria) of the body and pyloric antrum of the stomach. Although these tumors are usually benign, some of them may be malignant or potentially malignant. On gross inspection the mostly solitary lesions protrude hemispherically or polypoidly into the gastric lumen. The mucous membranes overlaying the tumor may be eroded or deeply ulcerated so that gastric hemorrhage is the most important clinical finding. Microscopically the tumor tissue is composed of large, rounded or polyhedral cells, which often contain empty vacuoles in their finely granulated acidophilic cytoplasm. The round or oval nuclei are located in the center or at the periphery of the cell, sometimes giving the impression of "signet ring" cells. The size and chromatin density of the nuclei may vary, mitotic figures are rare or missing. Often the tumor cells are disaggregated by accumulations of PAS-positive edema, which may also contain many large and confluent empty vacuoles. The reticulum stain reveals a dense network of fibers encircling individual or small groups of tumor cells, as it is characteristic for smooth muscle tissue. In 4 cases we observed small nodules, which were composed of concentrically arranged fibers and tumor cells resembling hemangiopericytoma without central blood vessel. During 6 years (1970 to 1975) we observed 6 cases of gastric leiomyoblastoma. None of these patients had evidence of recurrent disease or metastatic spread 2 to 6 1/2 years after operation and histological diagnosis of the tumor.

Adult↗
PubMed1979

Combined protein and DNA measurements by the ninhydrin-Schiff and Feulgen techniques.

Feulgen nuclear staining with pararosanilin-SO2 was combined with the ninhydrin-Schiff technique. The aldehyde groups converted from primary amino groups are stained with an acriflavine-Schiff reaction. This results in a red nuclear fluorescence and a bright yellow cytoplasmic and nuclear fluorescence. The combined fluorescence staining facilitates cytofluorometric determination of total protein and DNA in the same cell. The ninhydrin-Schiff reaction is affected by the fixation procedure and the duration of the ninhydrin reaction. Investigations with a model system showed that proportionality between the fluorescence intensity of acriflavine and the amount of protein stained by the procedure was obtained after fixation with a fixation mixture suggested by Böhm et al. (1968) and a reaction with ninhydrin at 37 degrees C for 10 h. The ninhydrin-Schiff reaction has no effect on the fluorescence intensity of cells previously treated with pararosanilin-Feulgen staining and it is not affected itself by this previous procedure. Testing this double fluorescence staining on cytology specimens taken from patients with gastric carcinoma and uterine cervial carcinoma, cancer cells were shown to have markedly increased protein and DNA contents compared with those of normal cells.

Adult↗
PubMed1978

[Age-dependency of toluidine-blue dichroism and birefringence of fibers within the costo-chondral junction of human ribs (author's transl)].

The chondral fibers running parallel to the chondrocyte columns within die costo-chondral junction of human ribs were investigated quantitatively following standardized Toluidine blue staining by using the Leitz-Mikrospektrograph for observing the absorption spectrum, and by employing both a Berek- and a Brace-Köhler compensator for polarization measurements. Autopsy material was obtained from the ribs of 35 children and adults at the age of 0 to 22 years. Refractivity was measured in stained and unstained paraffin sections, whereas dichroism and metachromatic index (MI) of the fibers were determined in stained specimens. All three parameters showed characteristic, quantitative age-dependent variations indicating that the highest degree of molecular and structural adjustment and alignment of the fibers is already being reached at the age of 8 years. The continuously higher refractivity of the fibers with increasing age and bone maturity may be explained by a progressive loss of water by the fibers.

Adolescent↗