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Biomedical subjects

N Başaran

Publications and source records attributed to N Başaran.

32 records · Page 2Linked to original sources
PubMed1994

Effects of consanguinity on anthropometric measurements of newborn infants.

The effects of parental consanguinity on gestational age and birth measurements were evaluated on 2880 newborn infants. Consanguineous marriages were considered in three subgroups: first-cousin, first-cousin-once-removed and distant-cousin marriages, versus non-consanguineous marriages. Anthropometric parameters were weight, length, leg length, head, chest and mid-arm values obtained within 24 h of birth. No significant differences were found concerning gestational age. Although anthropometric values were slightly less, especially in children from first-cousin couples, the differences were insignificant for all groups. It was concluded that blood-relationship alone does not affect such multifactorial traits.

Anthropometry↗
PubMed1994

Chromosome analysis in pleural effusions. Efficiency of this method in the differential diagnosis of pleural effusions.

Various laboratory methods are being used to acquire diagnosis in pleural effusions. However, about 20% of the effusions cannot be diagnosed reliably. Cytogenetic analysis in pleural effusion is not used routinely, although many numerical and/or structural chromosome abnormalities have been observed in malignant pleural effusions. In this study, a total of the 61 pleural effusion samples, 34 malignant which included 19 diffuse pleural malignant mesothelioma, 15 metastatic malignant pleural effusions and 27 benign, were analyzed by direct chromosome analysis method. To the findings obtained in the study, 85.3% (29/34) of the 34 patients with malignant pleural effusion had numerical and/or structural abnormalities, and 3 of them had no mitosis. The patients who had benign pleural effusion indicated no numerical and/or structural abnormalities. We have concluded that if a pleural effusion cannot be reliably differentiated by the usual laboratory methods and especially malignancy is strongly suspected, cytogenetic analysis can be used to differentiate malignant effusions from benign effusions with a small rate of error, and also it can indicate that more invasive diagnostic procedures are necessary.

Adult↗
PubMed1994

Selenium status in Turkey. II. Serum selenium concentration in healthy residents of different ages in Ankara.

In this study we determined the serum selenium concentraction of 218 healthy individuals at different ages, in Ankara, using a spectrofluorimetric method. The mean selenium levels were found to be 45 +/- 10 micrograms/L in cord blood at birth; 69 +/- 13 micrograms/L in 2 month-12 month-old infants; 77 +/- 12 micrograms/L in children aged > 12 months-16 years; and 74 +/- 16 micrograms/L in adults aged 18-48 years. Selenium concentrations showed age dependency, increasing significantly in childhood but decreasing after 40 years of age. No relation to the sex, dietary habits, socioeconomical status or hematological parameters such as hemoglobin concentration and white blood cell count, was observed. The results obtained thus suggest that the status of selenium in Ankara residents is in a range that could be considered as safe and adequate.

Adolescent↗
PubMed1993

Dacryocystitis associated with osteopoikilosis.

We report five members of a family with dacryocystitis associated with osteopoikilosis. The inheritance is autosomal dominant. Review of the literature revealed no other report of this kind of association. Osteopoikilosis must not be considered as a coincidental radiographic finding but as part of a systemic disorder.

Adolescent↗
PubMed1992

Consanguineous marriages among parents of Down patients.

In order to reveal if there is an effect on the genesis of meiotic- or early zygotic non-disjunctions, data related to 1598 Down syndrome patients from 1578 families studied in five different genetic centers in Turkey are reported. Parental consanguinity and the inbreeding coefficient were found to be lower among patients of 21-trisomics than in parents without Down offspring. It was concluded that available information does not support the presence of a "non-disjunction gene" in man.

Consanguinity↗
PubMed1992

Serum selenium status in children with iron deficiency anemia.

Serum selenium concentration was investigated in 40 children with iron deficiency anemia and in 40 control subjects matched for age, sex and geographical origin. A spectrofluorometric method was used for determination of the selenium level. It was found to be significantly lower (p < 0.001) in the patient group, which consisted of both normally developed and malnourished children. Patients also having pica had higher levels of selenium compared to patients without pica. There was no relation between the serum selenium concentration and hematological parameters such as hemoglobin, serum iron, serum iron binding capacity and unsaturated iron binding capacity. However the results of 15 patients followed during iron therapy indicated that the duration of the anemic period may affect the selenium concentration. This study also suggests the effectiveness of iron and selenium administration.

Adolescent↗
PubMed1989

Serum immunoglobulins, complement levels and lymphocyte subpopulations in phenytoin-treated epileptic patients.

The peripheral blood lymphocytes, serum immunoglobulins, C3 and C4 complement protein concentrations of 20 patients with idiopathic epilepsy who were receiving phenytoin were examined and compared with 30 healthy controls in order to obtain a detailed profile of the effects of the drug on the humoral and cellular immune systems. The T-lymphocyte subsets were identified using monoclonal antibodies. A significant decrease in suppressor T-cells (p less than 0.05) and an increase in the ratio of T-helper to T-suppressor lymphocytes (p less than 0.01) have been found. Furthermore, an increase in B-lymphocytes (p less than 0.01) and a significant rise in serum Ig M concentrations (p less than 0.05) have been observed. No significant changes in serum concentrations of Ig G, Ig A and complement proteins were detected.

Adolescent↗
PubMed1988

Consanguineous marriages in the Turkish population.

This study of 55,175 marriages in Turkey, conducted from 1970 to 1987, showed an overall rate of consanguineous marriage of 21.21% (mostly first-cousin liaisons) and an inbreeding coefficient of 0.0064532. However, considerable differences between areas are apparent.

Adolescent↗
PubMedDate not supplied

Effects of ciprofloxacin on chromosomes, and hepatic and renal functions in rats.

In the present study, ciprofloxacin, a fluoroquinolone antibiotic, was evaluated in vivo. The toxic effects of ciprofloxacin (20 and 200 mg/kg/day) on kidney and liver functions, and on chromosomes were investigated in rats. 20 mg/kg/day ciprofloxacin did not significantly affect urine composition, serum enzyme levels and the haematocrit, affecting only creatinine clearance. The 200 mg/kg/day dose increased urine volume, serum creatinine and and creatinine clearance. Ciprofloxacin at both doses had no significant numerical effect on chromosomes, but there was a statistically significant dose-dependent increase in chromatid-type breakage. Significant histological changes in the liver and kidney were not observed.

Alanine Transaminase↗