Biomedical subjects

N Basić

Publications and source records attributed to N Basić.

At least 19 recordsLinked to original sources

PubMed2002

Long-term results of conventional-dose salvage chemotherapy in patients with refractory and relapsed Hodgkin's disease (Croatian experience).

BACKGROUND: The aim of this study was to analyze outcome of patients with Hodgkin's disease (HD) in whom first-line chemotherapy with mustine/vincristine/procarbazine/prednisone (MOPP) had failed. PATIENTS AND METHODS: From January 1982 to December 1989 among 210 patients treated with MOPP and radiotherapy to initial bulky sites, 65 patients were primary refractory to or relapsed after initial treatment. RESULTS: Twenty-nine of 65 patients (44%) were primary refractory to initial chemotherapy, 20 relapsed within 12 months after complete remission (CR) and 16 relapsed after CR that lasted more than 12 months. Patients with primary refractory HD and early relapse (<12 months after CR) were treated with doxorubicin/bleomycin/vinblastine/darcarbazine. In patients with late relapse (>12 months after CR) MOPP was repeated. The median follow-up for all patients was 115 months. The overall response rate was 63%. Thirty-three patients (51%) achieved a second CR and eight patients (12%) partial response. Remission rate was greatest in patients with late relapse (CR >12 months) (75 versus 55% for early relapse versus 35% for primary refractory HD) (P <0.01). At 10 years, overall and failure-free survival rates were 21 and 16%, respectively. Patients who were in first remission longer than 12 months had a superior overall survival (37 versus 18% for early relapse) and failure-free survival (24 versus 10% for early relapse). No patient with primary refractory HD was alive beyond 52 months after initial treatment failure (P <0.01). Main prognostic factors were duration of the first remission and tumor bulk at relapse. CONCLUSIONS: Our results confirm previous observations that a significant proportion of patients with HD who experience induction treatment failure cannot be cured with conventional treatment and probably need more aggressive therapy.

Adolescent↗

PubMed1999

Computed tomographic imaging to determine the frequency of anatomical variations in pneumatization of the ethmoid bone.

The present study was performed on axial and coronal CT scans of 212 patients. Scans were analyzed by an anatomist and a radiologist for the presence of Haller's cells, agger nasi cells, Onodi's cells and pneumatized crista galli. Results demonstrated the presence of Haller's cells in 21.2%, Onodi's cells in 10.4% and pneumatized crista galli in 2.4% of patients. A pneumatized anterior clinoid process was found in 0.5% of the patients. The data obtained in our study were compared with those reported in other anatomic and radiologic studies.

Adult↗

PubMed1997

Regeneration of articular cartilage defects in rabbits by osteogenic protein-1 (bone morphogenetic protein-7).

Osteogenic protein-1 (OP-1, BMP-7), a member of the transforming growth factor-beta family, induces cartilage and bone formation when implanted at intra and extraskeletal sites in vivo. The human OP-1 gene has been cloned and biologically active recombinant OP-1 homodimers have been produced. In the present study, the authors investigated the influence of OP-1 on healing of full-thickness articular cartilage defects, made by drilling two adjacent (phi 3mm) holes through articular cartilage of NZW rabbit knee joint were dissected and examined histomorphometrically. Results indicated that OP-1 induced articular cartilage healing and regeneration of the joint surface which contained cells resembling mature joint chondrocytes. These data imply a new strategy for biological repair of damaged joint surfaces in humans.

Animals↗

PubMed1997

Differences between male and female breast cancer. II. Clinicopathologic features.

The aim of this study was direct comparison of clinicopathologic features in male and female breast cancer patients. The study included 100 male and 500 female patients with pathohistologically confirmed breast cancer, who were treated at the University Hospital for Tumors in Zagreb, Croatia, between 1970 and 1990. The results revealed significant sex-related differences in the following characteristics: patients age at diagnosis (36% vs. 66% below the age of 60, respectively, p < 0.001), delay in treatment (29% vs. 58% within the first 3 months, p < 0.001), tumor size (45% vs. 58% up to 5 cm, p < 0.001), number of affected regional lymph nodes (74% vs. 87% up to 5 nodes, p < 0.01), TNM-stage distribution (49% vs. 56% in stages I-II, p < 0.001), estrogen receptor values (69% vs. 32% > 10 fmol/mg protein, p < 0.001) and progesterone receptor values (67% vs. 48% > 10 fmol/mg protein, p < 0.05). No significant sex-related differences in breast cancer patients were found regarding histologic grade of malignancy (males: grade I-36%; II-34%; III-30%; females: grade I-33%; II-36%; III-31%), affected breast (left in 58% males vs. 50% females), and type of surgical treatment (modified radical mastectomy in 64% male vs. 61% female patients). This study confirmed the well-known facts that male breast cancer develops at an older age and with a much higher proportion of positive tumor hormone receptors. Furthermore, the authors found the male patients in Croatia to be insufficiently informed about the possibility of breast cancer development in male sex, which resulted in a significantly prolonged treatment delay and, consequently, higher TNM stage of the disease, bigger tumors and more affected lymph nodes at the time of diagnosis in comparison to female patients.

Adult↗

PubMed1997

Differences between male and female breast cancer. III. Prognostic features.

The aim of this study was direct comparison of prognostic features in male and female breast cancer patients. The study included 100 male and 500 female patients with pathohistologically confirmed breast cancer, who were treated at the University Hospital for Tumors in Zagreb, Croatia, between 1970 and 1990. Stage-adjusted univariate analysis of differences in five-year overall survival revealed similar prognosis in both sexes when the disease was in TNM-stages I and II (males: 95% and 80%; females: 90% and 79%, respectively). However, the study showed that in TNM stages III and IV, male patients had a significantly worse five-year overall survival (males: 39% and 5%; females: 61% and 27%, respectively; p < 0.05). The impact of ten clinicopathologic characteristics on survival in males and females was also analyzed through the multivariate statistical analysis, in this case by multiple regression. Analyzed characteristics included patient age at diagnosis, delay in treatment, tumor size, number of affected lymph nodes, TNM-stage, histologic grade, affected breast, estrogen and progesterone receptor values, and type of surgery. An extremely intriguing finding was that the percent of survival variance explained by ten selected predictors (R2) amounted to as much as 78.7% in males, in comparison to only 23.1% in females. Three predictors that explained most of the survival variance in males were TNM-stage (21.0%), number of affected lymph nodes (19.5%) and delay in treatment (16.2%). The most important corresponding prognostic factors in females were number of affected lymph nodes (12.7%), histologic grade (6.6%) and tumor size (5.9%). The authors concluded that, from the prognostic point of view, male and female breast cancer represent two quite different diseases: in males, the outcome can be very precisely predicted from the basic clinicopathologic characteristics of the disease, while in females there is probably a wide spectrum of other factors with a significant influence on the prognosis, which require additional studies.

Adult↗

PubMed1997

[The role of bone morphogenetic proteins in compensatory renal growth].

Bone morphogenetic proteins are members of transforming growth factor beta superfamily. Bone morphogenetic protein-7 (BMP-7) has been recognized as a key signalling molecule during the kidney development and is capable of protecting kidney against acute renal failure in postnatal life. In the present study the involvement of BMP-7 in the kidney compensatory growth after unilateral nephrectomy has been explored. Northern analysis of mRNA from 3 to 21 days after surgery indicated that BMP-7 message was unchanged thus excluding BMP-7 as a compensatory growth agent.

Adaptation, Physiological↗

PubMed1992

[Dental pulp in carious teeth].

Various etiologic causes lead to dental pulp changes ranging from inflammation to necrosis. The most frequent changes, however, are caused by bacterial activity and toxins from carious process. According to the opinion of various authors and on the basis of our investigations the conclusion can be made that all the forms of dental pulp changes can be developed as the sequela of the disease of supporting apparatus. Pathohistologic examination of dental pulp of cariously damaged teeth showed that the occurred changes are mostly the sequela of inflammation and regressive and progressive changes are found as well.

Adult↗

PubMed1986