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N Bathurst

Publications and source records attributed to N Bathurst.

3 recordsLinked to original sources

Turcot's syndrome. A review.

Turcot's syndrome represents the association between familial multiple polyposis coli and neural tumors. The syndrome is reviewed with reference to genetics, colonic and central nervous system manifestations. This evidence suggests that Turcot's syndrome represents one manifestation of the pleiotropic autosomal dominant gene responsible for familial polyposis coli and the associated extracolonic manifestations of Gardner's syndrome. A diagnosis of Turcot's syndrome should be restricted to those patients with familial polyposis coli associated with gliomas or medulloblastomas. A further case is presented that is believed to be the first report of such a case in the United Kingdom.

Adenomatous Polyposis Coli↗

Osteoclast-rich osteosarcoma.

Nine cases of primary osteoclast-rich osteosarcoma, an undifferentiated sarcoma with an overabundance of osteoclasts and a paucity of tumour osteoid, are reported. They comprise about 3% of all primary osteosarcomas and are histologically related to telangiectatic osteosarcoma, another undifferentiated tumour with abundant osteoclasts and scanty osteoid, perhaps being a predominantly solid variant of the latter. Many of the classical radiological features of an osteosarcoma are absent in these cases and differentiation from a benign lesion is sometimes difficult. Typically, an ill-defined margin surrounds a predominantly lytic lesion of the diaphysis or metaphysis of the femur or tibia of a young patient. A soft-tissue mass is not usually present and periosteal reaction is scanty.

Adolescent↗