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N Biçakçi

Publications and source records attributed to N Biçakçi.

7 recordsLinked to original sources
PubMed2001

Flow-cytometric analysis of lymphocyte subsets and mCD14 expression in patients with various periodontitis categories.

BACKGROUND: Membrane-bound CD14 (mCD14) is expressed mainly on circulating monocytes and tissue macrophages. It is one of the receptors, which act at the recognition of lipopolysaccharides by host cells. Periodontopathic bacteria result in activation of cellular and humoral immune responses. AIM: The aim of the present study was to analyze the peripheral blood mCD14 concentrations as well as cell surface markers of lymphocyte subsets in periodontitis patients of various categories. MATERIALS AND METHODS: Peripheral blood samples were obtained from 22 early onset periodontitis (EOP), 10 adult periodontitis (AP) patients and 13 systemically and periodontally healthy control subjects. Three-color flow cytometry and a panel of relevant monoclonal antibodies were used to determine the percent expression of various cell surface markers on peripheral blood mononuclear cells (PBMCs). The results were tested statistically by one-way variance analysis and Newman Keuls test. RESULTS: No significant difference was observed between the study groups with regard to the relative counts of B-cells, T-cells, T-helper, T-cytotoxic/suppressor, activated T-cells and natural killer cells. EOP patients expressed significantly lower level of interleukin-2 receptor (IL-2R) when compared with AP patients (6.08% and 19.3% respectively) (p<0.05). The level of mCD14 in EOP patients (7.18%) was lower than that of AP patients (9.3%) and the control subjects (9.2%), but the differences were not statistically significant. CONCLUSIONS: The low level of IL-2R in the EOP group may be interpreted as an insufficient responsiveness to the periodontopathogens, which may be ultimately related with the more severe tissue destruction. Though not significant, the reduced expression of mCD14 in EOP group may also be related with the immune system deficiencies in these patients.

Adolescent↗
PubMed1996

The effect of non-surgical periodontal and adjunctive minocycline-HCL treatments on the activity of salivary proteases.

The purpose of this investigation was to evaluate the effect of non-surgical periodontal treatment and adjunctive systemic minocycline therapy on the level of neutral protease activity in whole saliva of adults with periodontitis. A test group of 21 adult patients with moderate to severe periodontitis was compared to a control group of 5 adults with healthy periodontium. Four test groups were examined: 1) scaling and root planing (SRP), probing depth = 4 to 5 mm; 2) SRP, PD > or = 6 mm; 3) SRP and adjunctive systemic minocycline therapy, PD = 4 to 5 mm; 4) SRP and adjunctive systemic minocycline therapy, PD > or = 6 mm. Clinical parameters and levels of neutral protease in whole saliva were assessed at baseline and on the sixth week after the non-surgical periodontal treatment. Neutral protease activity was measured by spectrofluorimetric method. Statistical tests of Mann-Whitney and Spearman Rank correlation coefficient were used in the evaluation of the mean values of measurements. The mean values of protease activity were significantly higher in the test groups than in the control group at baseline. Six weeks after non-surgical therapy, patients with 4 to 5 mm probing depth had approximate values of protease activity comparable to the control group. Hence it can be argued that these patients did not need minocycline HCL as an adjunctive therapy. However, non-surgical therapy had limited effects on both clinical parameters and enzyme activities for subjects with > or = 6 mm probing depth; on the other hand, gingival inflammation and enzyme activities were reduced significantly by the usage of minocycline as adjunctive therapy in these patients. According to our results, neutral protease activity in saliva is related to probing depth and gingival bleeding index, and not related to age and epithelial cell number. For these reasons, systemic minocycline therapy might be useful as an adjunct to non-surgical therapy in the presence of deep pockets, especially for reinfected cases. Further investigations are needed to confirm this suggestion.

Adult↗
PubMed1995

A case of myiasis gingiva.

A case of myiasis gingiva was diagnosed in an investigation designed to evaluate the histopathological features of the adjacent tissues of 100 advanced periodontal lesions. The patient was a 36-year old female and her chief complaint was discomfort and swelling in the area between the upper left central and lateral incisors. The patient's medical history, review of the symptoms, and family history were non-contributory and her oral hygiene was acceptable. The surgeon was not aware of anything unusual during the operation. Although the Parasitology Department was unable to define the entomologic identification of the infesting parasite from histopathological tissue slides, it was agreed that this case of myiasis might be produced by larvae of genus Sarcophaga or Enterobius vermicularis.

Adult↗
PubMed1993

The effect of alloxan diabetes and local irritating factors on gingival lymphocytes and plasma cells and serum IgG, IgM and IgA levels.

A histologic study was conducted in 5 diabetic and 5 non-diabetic albino rabbits to determine the effect of experimentally induced diabetes upon the number of gingival plasma cells and lymphocytes in the absence and presence of local factors, and IgG, IgM and IgA levels of the four groups were compared with each other. In conclusion, local factors were primarily responsible for the increase of the gingival plasma cells and lymphocytes. There was no statistically significant difference between the diabetic and non-diabetic group in the absence of local factors. Also, there was no marked difference between the serum IgG, IgA and IgM levels of all groups.

Animals↗
PubMed1992

The effect of zinc chloride dentifrices on plaque growth and oral zinc levels.

The antiplaque potential of zinc salts has been previously demonstrated. The purpose of the present investigation was to establish the effect of zinc chloride dentifrices on plaque growth and on the concentration of zinc in saliva and plaque. Zinc levels in saliva and plaque were measured by atomic absorption spectrophotometry. Elevated zinc levels were observed in saliva and in plaque for 1 hour after contact with a zinc chloride dentifrice. Increased concentrations of zinc were also observed in plaque residue. Further analysis of data showed that subjects with high rates of plaque growth benefited more from the zinc dentifrices than did those with low rates of plaque growth.

Adult↗
PubMedDate not supplied

[Painless pulpitis].

Explore the source record for details and available documents.

Pulpitis↗