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N Bornstein

Publications and source records attributed to N Bornstein.

70 records · Page 4Linked to original sources
PubMed1982

[Legionnaires' disease with digestive tract lesions. One case].

In the case reported pulmonary Legionella infection was diagnosed by sputum cultures even though immunofluorescence tests were negative. The patient had positive Coomb's test due to circulating auto-antibodies which disappeared after he recovered. The course of the disease was prolonged by perforation of the coecum requiring excision of the colon and terminal ileostomy. Erythromycin had to be given intravenously. Pathological examination of the digestive tract lesions showed inflammatory colitis with presence of Legionella pneumophilia which seemed to have been responsible for the complication. This is the first time a digestive lesion caused by this organism is described, adding yet another extrapulmonary visceral involvement to those already reported and suggesting that Legionella may spread throughout the body.

Autoantibodies↗
PubMed1982

[Diseases of the lungs caused by legionella species (author's transl)].

Ever since the 1976 Philadelphia epidemic and the isolation of the causative organism by MacDade in 1977, numerous clinical, epidemiological and bacteriological papers have stressed the significance of the "new" causative organisms responsible for serious cases of pneumonia. On the basis of knowledge available at present, the Legionellaceae family accounts for these bacteria. There are five different species in the genus Legionella: L. pneumophila, L. micdadei, L. bozemannii, L. dumoffii and L. gormanii. L. pneumophila occurs most frequently and has six serogroups (Serogroups 1-6), the first of which is the most important. Legionelloses, the diseases caused by these organisms, occur epidemically, endemically or sporadically. In clinical terms, these are acute cases of pneumonia which occur especially frequently in older persons and immunocompromised hosts. The course is severe in such patients. There is increased lethality. Erythromycin, rifampicin and cefoxitin are the most effective antibiotics. After the culture has been made in the suitable milieu and the material obtained by pulmonary aspiration has been inoculated into guinea pigs, the bacteriological diagnosis is made by direct immunofluorescence. The serological diagnosis is based on evidence of serological changes demonstrated by the indirect immunofluorescence test.

Adult↗
PubMed1982

[Practical problems raised by antibiotic minimal inhibitory concentration determination in Legionella species (author's transl)].

Because of culture medium constitution and growth conditions of Legionella species, antibiotic Minimal inhibitory Concentration (MIC) determination is difficult and does not fit with the accepted standards. The following strains have been tested : references strains : Staphylococcus aureus Oxford CNCM 53154, S. aureus 209P CNCM 53156, E. coli CNCM A224, E. coli CNCM 7324. L. pneumophila, 9 strains representative of the 6 serogroups. L. micdadei, L. dumoffii. 5 clinical isolates of L. pneumophila serogroup 1 (3 isolated in our Laboratory and 2 in Belgium). MIC of 17 antibiotics have been determined, among them macrolids not tested before. The method used was the Agar Dilution Method, with several media compared. MIC values are different in function of the various media tested Charcoal yeast extract medium, which is recommended for Legionella growth, does not inhibit activity of penicillin G, cefalotin, cefoxitin, amikacin, erythromycin and lincosamins, in contrast of tetracyclin, gentamicin, dibekacin, chloramphenicol, oleandomycin, pristinamycin, spiramycin and rifampicin. Charcoal, ferric pyrophosphate and L-cystein present in the culture medium are inactivating factors. However our results confirm good activity of rifampicin, erythromycin, cefoxitin, chloramphenicol, gentamicin and amikacin. Among the others macrolids tested, pristinamycin is the most active.

Anti-Bacterial Agents↗
PubMed1981

CSF renin activity in hypertensive and normotensive patients.

CSF samples of hypertensive and normotensive matched groups were assayed and compared for renin activity (RA). The measurements yield low values of RA in both groups without significant difference between them. There was no correlation between the CSF level of RA of each patient and his own concomitant plasma renin activity (PRA). Although the presence of RA in the CSF was confirmed in this study, no direct correlation seems to exist between it values and the elevated blood pressure; therefore, the pathophysiological significance of the renin-angiotensin system in the CSF and its relation to centrally generated hypertension remains questionable.

Aged↗
PubMedDate not supplied

Cardiac manifestations of myotonic dystrophy.

Twenty-four patients with Myotonic Dystrophy (MyD), age 19-66 years, underwent non-invasive cardiac evaluation which included physical examination, resting and 24 h ECG recording, echocardiography, and multigated radionuclide (Tc99) scanning (MUGA) to assess left ventricular ejection fraction (LVEF). Only 4 of the 24 patients studied did not display any cardiac pathology. Though most patients (20 out of 24) were free of cardiac symptomatology, 15 had abnormal resting ECG. In 12 of the patients mild rhythm disturbances were present in the 24 h ECG monitoring. Left ventricular contraction impairment was a most striking feature; it was noted in 8 patients, in whom the LVEF was below 50%. The apical region was the most affected. Seventeen patients showed abnormal echocardiographic findings: mitral valve prolapse was noted in 8, dilatation of left atrium in 5 and of the left ventricle in 2 of the 24 patients. No correlation between the severity of muscular impairment and the cardiac manifestation was seen. No correlation was found between disease duration or severity (as judged by the functional capacity of the patients) and its cardiac manifestations.

Adult↗
PubMedDate not supplied

[Isolation and characterization of the three first strains of "Legionella pneumophila" found in France (author's transl)].

The technical methods of culture and identification of the three first strains isolated in France of Legionella pneumophila serogroup 1, are described. In two patients, bacilli were seen by the direct fluorescent antibody (DFA) method, either during the course of the disease (case 1) or at postmortem examination (case 3). The causal strain was cultivated after guinea-pig inoculation or directly from either bronchial aspirate or postmortem lung. Identification of L. pneumophila required the determination of metabolic characteristics, DFA characterization and cellular-fatty acids analysis (by gas-liquid chromatography). In the three cases, a significant seroconversion was detected by indirect fluorescent antibody test. The relative value of the differnt methods of diagnostic methos is discussed and the importance of strain isolation is emphasized.

Aged↗
PubMedDate not supplied

[Detection of "Staphylococcus aureau" protein A on selective culture media (author's transl)].

Production of protein A by 100 various animal strains and 106 human strains of Staphylococcus aureus has been detected by conditioned haemagglutination after growth on seven different culture media: agar medium at n degrees 2 and Columbia agar with and without nalidixic acid (10.8 micrograms/ml), Baird-Parker, Chapman and tellurite-glycine-agar media. Rate of protein A-producing strains is as high on nalidixic acid media as on the same media without antibiotic. Baird-Parker, Chapman and tellurite-glycine-agar media are not convenient for protein A detection.

Culture Media↗