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Biomedical subjects

N Bruneel

Publications and source records attributed to N Bruneel.

5 recordsLinked to original sources
PubMed2006

Occurrence of polychlorinated biphenyls and polybrominated diphenyl ethers in belgian human adipose tissue samples.

Levels of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) were measured in 53 human adipose tissue samples. The samples consisted of adipose tissue from 31 men and 22 women having a mean age of 53 years. No information about diet or occupational exposure was collected. Cleanup was performed using a glass column containing acidified silica, deactivated alumina, and anhydrous sodium sulphate. Subsequently, samples were analyzed by high-resolution gas chromatography/tandem mass spectrometry. PBDE concentrations (sum of BDEs 28, 47, 99, 100, 154, 153, and 183) ranged between 1.23 and 57.2 ng g(-1) lipid weight and were comparable with levels in samples from other European countries. The sum of seven International Council for the Exploration of the Sea (ICES) indicator PCB congeners (PCBs 28, 52, 101, 118, 138, 153, and 180) ranged from 126 to 2090 ng g(-1) lipid weight. No age dependency was found for PBDEs (Pearson correlation -0.023, p = 0.873), whereas PCBs showed higher correlation coefficients with age (Pearson correlation 0.613, p < 0.0005). There was no relationship between PBDE and PCB levels (Pearson correlation -0.010, p = 0.943).

Adipose Tissue↗
PubMed2005

Monitoring of polychlorinated biphenyls in Belgian human adipose tissue samples.

Polychlorinated biphenyls (PCBs) were monitored in Belgian human adipose tissue samples from deceased individuals (n=100). Their mean age was 52, ranging from 2 to 91 years. There were 57 men and 43 women. Other known variables were date of autopsy and place of residence. No information about diet or occupation was available. The seven marker congeners PCB 28, 52, 101, 118, 138, 153 and 180 were analysed in the samples with a GC-MS/MS method validated according to Commission Decision 2002/657/EC. Extracted fat was cleaned-up over a glass column filled with n-hexane, acid silica, deactivated alumina and anhydrous sodium sulfate. The whole procedure was subjected to a rigorous quality control programme with retention times, ion chromatograms and intensity ratios of the monitored product ions as identification criteria. The total PCB concentration ranged between 10 and 1640 ng g-1 fat, with a mean value of 658 ng g-1 fat. In the age groups of 0-9 (n=1), 10-19 (n=4), 20-29 (n=11), 30-39 (n=13), 40-49 (n=15), 50-59 (n=14), 60-69 (n=14), 70-79 (n=20), 80-89 (n=6) and 90-99 (n=2), the mean total PCB concentrations were 10, 134, 253, 445, 557, 687, 807, 962, 959, and 1191 ng g-1 fat, respectively. So, there was an increase of PCB body burden with age. For the male subjects (n=57; mean age of 53) the mean total PCB concentration was 633 ng g-1 fat. For the female subjects (n=43; mean age of 52) it was 690 ng g-1 fat. There was no significant sex-related difference in the concentrations of marker PCBs.

Adipose Tissue↗
PubMed1988

In vitro simulation of biocompatibility of Ti-Al-V.

The presented data are the result of a reappraisal of the biocompatibility properties of titanium alloys. An in vitro study has been conducted using Hanks' solution with four different additional compounds (EDTA, l-leucine, Na-citrate, and 8-hydroxyquinoline). A measurable dissolution rate was observed for Ti and Al in a solution containing EDTA and for Ti, Al, and V for a solution containing Na-citrate. The dissolution kinetics are discussed and explained in terms of the composition of the surface layers. The results contain useful introductory information for an extended study of media allowing representative in vitro simulation of the in vivo behavior of titanium alloys.

Alloys↗
PubMed1976

A death case involving tilidine.

A fatal poisoning case due to the combination of a relative overdose of barbiturates (600 mg daily) and 750 mg of tilidine is reported. The concentrations of barbiturates and tilidine with its metabolites were determined in blood, liver, and urine.

Adult↗