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Biomedical subjects

N Buhles

Publications and source records attributed to N Buhles.

12 recordsLinked to original sources
PubMed2005

[Dermato-oncological rehabilitation].

National insurance companies in Germany support health cures for patients with malignant tumors (malignant melanoma, squamous cell carcinoma, Merkel cell tumor, malignant cutaneous lymphoma). The clinical requirements are an invasively growing tumor, problems of self-assurance, and dis-integration of the patient regarding his social and/or professional environment. The decision for a health cure is made by the treating dermatologist in the hospital. In this context, the following sociomedical criteria should be applied: impairment, disability, and handicap. Usually, rehabilitation starts after the patient is discharged from the hospital. The inpatient rehabilitation program should be performed at an institution capable of providing dermatological and psychological treatment. The dermatologist acts as a manager for the members of the rehabilitation team (psychologists, physiotherapists, social workers, and ergo-therapists). In conclusion, dermato-oncologic rehabilitation plays an important role in re-integrating the patient into his professional life to avoid retirement.

Combined Modality Therapy↗
PubMed2005

[The international classification of functioning, disability and health (ICF) in dermatological rehabilitation: conception, application, perspective].

Medical rehabilitation represents the interdisciplinary management of a person's functional health. This term implies concepts of functioning, disability and health and represents the core notion of the international classification of functioning, disability and health (ICF). Four components -- anatomic structure, body functions, activities and participation, environmental factors and personal factors -- make the ICF applicable from a biological, individual and social perspective. At present the ICF is used as a system of classification, a research tool and as a theoretical basis in rehabilitation medicine. Its clinical application will depend on the improvement of its practicability and compatibility with currently used tools in dermatologic rehabilitation. ICF offers the opportunity to define, weight and classify diseases of the skin and their psychosocial consequences.

Dermatology↗
PubMed1988

[Ultrasound microscopy of skin sections].

In vivo ultrasound examination has been introduced into dermatology as a non-invasive diagnostic technique. The resolution capacity, however, has been limited so far, and the in vivo ultrasonic features have not been fully understood. Using high frequencies (GHz range) in acoustic microscopy, we have been able to achieve a resolution comparable to that in light microscopy. In a first step, we examined normal human skin sections and compared them to histological specimens. The following study on melanocytic nevi, malignant melanoma, and metastases of melanoma showed that their acoustic images were more pronounced than those of the surrounding tissue. The echo intensity of solid basal cell carcinoma and squamous cell carcinoma resembled that of the epithelium. The structures found in acoustic microscopy can be correlated to those seen in light microscopy.

Biopsy↗
PubMed1987

[UV light sensitivity of the skin--possibilities and limits of clinical diagnosis].

Our study on 58 test persons showed that the sensitivity of human skin to UV light is independent of the color of skin, hair, eyes or the pigmentation of the mamillae. Therefore, the sensitivity to UV light must be ascertained by subtle phototesting. By means of the new UV phototesting set SBA-LT-400, Saalmann Co., 4900 Herford/West Germany, we determined the minimal erythema doses (MED) of UV-B and UV-A as basic, reproducible parameters regarding Central European people. 7 and 24 hours after radiation, MED showed mean values of 0.032 and 0.037 Joule/cm2, resp., for UV-B, whereas 24.1 and 25.6 Joule/cm2 were measured for UV-A. The pigmentation responses to UV radiation of human skin described in the literature can be reproduced in Mediterranean skin types only.

Adolescent↗
PubMed1987

[Disorders of steroid metabolism in inflammatory skin diseases].

The corticosteroid and androgen metabolites in the urine of 37 test subjects (11 healthy volunteers, 16 patients with eczema, and 10 patients with psoriasis) were investigated by means of gas chromatography and mass spectrometry. In addition, we studied the cortisol and testosterone levels in the plasma by radioimmunoassay. Those patients who had been treated with corticosteroids during the last two weeks were excluded. Our findings revealed that the excretion rate of steroid metabolites was significantly reduced in dermatological patients. The excretion rate of corticosteroids in urine was decreased an average of 25% (eczema) and 29% (psoriasis). The reduction of the androgen metabolites amounted to 26% and 31%. Cortisol and testosterone levels in the plasma were normal in all the cases.

Adrenal Cortex Hormones↗
PubMed1987

[Skeletal scintigraphy in diseases of the psoriasiform group. A study in 182 patients].

Bone scintigraphy using 99mTc-EHDP was carried out in 147 psoriatics of both sexes and in 35 nonpsoriatic patients. The psoriatics were subdivided into four groups according to clinical aspects: psoriasis vulgaris (Pv, n = 55), psoriasis inversa (Pinv, n = 32), psoriasis pustulosa of the Königsbeck-Barber type (PpK-B, n = 28), and pustulosis palmaris et plantaris (Ppp, n = 32). The following frequencies of joint involvement were found in the different groups: Pv = 18.3%; Pinv = 22.6%, PpK-B = 11.1%; Ppp = 12.5%; control group 2.3%. In patients suffering from psoriasis vulgaris and psoriasis inversa a pathologic preferential radionuclide uptake was demonstrated in the small peripheral joints of the hands and fingers. The characteristic psoriatic pattern with axial and transverse joint involvement was found in all groups of psoriatic patients. No correlation could be proved between age and pathologic accumulation of the radionuclide or between duration of psoriasis and joint involvement. The so-called anterior chest wall syndrome was found in all patients, but predominantly in those with psoriasis palmaris et plantaris. Finally the indications for bone scintigraphy are discussed.

Arthritis↗
PubMed1986

Influence of topical corticosteroids on hormones in urine and plasma.

In the present study the effects on endogenous hormones of application of topical corticosteroids are investigated. Radioimmunological assays of the hormones cortisol, adrenocorticotrophic hormone (ACTH) and alpha-melanocyte stimulating hormone (alpha-MSH) before, during and after a large-area treatment with topical corticosteroids (30 g/d 0.025% fluocinolone acetonide ointment for 9 days) are performed in eight patients suffering from extensive inflammatory dermatoses (7 cases of eczema, 1 case of psoriasis). Cortisol was measured in plasma daily under treatment. In addition, gas chromatographic and mass spectrometric determinations of urocorticoids and uroandrogens are carried out in 24-h urine. A distinct, treatment-induced suppression of the endogenous steroid production was significant (-42.7%, p less than or equal to 0.05) within the first four days and diminished (-24.4%, p less than or equal to 0.10) after nine days' steroid therapy. The suppression of the plasma ACTH was also significant (-23.1%, p less than or equal to 0.05). The alpha-MSH level did not show any alterations. The measured urocorticoids showed an average fall of -38.9% (p less than or equal to 0.05). It is noteworthy that despite continued steroid treatment the marked initial suppression of the endogenous steroid production diminishes. It is possible that a therapy-induced "normalization" of the epidermis brings about a diminished steroid influx and thus a lower systemic load. Under the therapy conditions chosen here, the androgen metabolites in the urine did not show any significant fluctuations.

Administration, Topical↗
PubMed1982

[Necrobiosis lipoidica].

The most important morphological aspects and pathogenesis of necrobiosis lipoidica concerning histological and clinical aspects are reported. In case of diabetes we find more frequently necrobiosis lipoidica localized out of the shank than in cases of necrobiosis lipoidica without diabetes. Necrobiosis lipoidica must be differentiated from granulomatosis disciformis, localized scleroderma and atrophy of the skin of another origin. Beside normalization of diabetes and application of corticosteroids physical and surgical treatment is recommended.

Adrenal Cortex Hormones↗
PubMed1981

Tolerance to corticoids? Guinea pig epithelium as an experimental system.

The antiacanthogenic effect of topical applied steroids is well known and maybe exactly assessed and quantified by means of the test procedure described. A 0.1% clobetasol-17-propionate solution induces an antiacanthogenic effect of 27.5% after a 28-day treatment period. After 84 days, the skin further treated with the corticosteroid shows an antiacanthogenic effect of 23.7% and after 118 days of 39%. A steroid tolerance of epithelial layer on guinea pig skin cannot be derived from our results.

Animals↗