Biomedical subjects

N Burlinson

Publications and source records attributed to N Burlinson.

2 recordsLinked to original sources

PubMed2002

Simultaneous selective detection of multiple quantum spectra.

A three-dimensional multiple-quantum NMR experiment that produces individual spectra of all quantum orders is described. The separation of different quantum orders is accomplished via Fourier transformation with respect to the phase of the first two pulses of a generic three-pulse multiple-quantum sequence. This dramatically reduces the time required to obtain several selectively detected spectra and enhances the sensitivity and digital resolution from that obtained using the original two-dimensional technique. The experiment is demonstrated on the protons of para-chlorotoluene dissolved in the nematic liquid crystal Merck ZLI-1132.

Fourier Analysis↗

PubMed1985

Physico-chemical and microbiological comparison of nystatin, amphotericin A and amphotericin B, and structure of amphotericin A.

Two polyene antibiotics, nystatin and amphotericin A, were compared by physico-chemical and microbiological methods. The two antibiotics were found to have the same molecular weight, 926, by plasma desorption and electron-impact MS. However, 13C NMR spectrometry and HPLC studies indicated that the two molecules are different. The 200 MHz NMR studies indicated a chemical environment of 24 carbons of amphotericin A identical with that of the carbons of amphotericin B and nystatin. The structure of amphotericin A is identical with that of amphotericin B, except that there is a single bond between carbons 28 and 29 instead of a double bond, as shown by two-dimensional NMR studies.

Amphotericin B↗