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N C McCarthy

Publications and source records attributed to N C McCarthy.

7 recordsLinked to original sources
PubMed1985

Expression in normal adult, fetal, and neoplastic tissues of a carbohydrate differentiation antigen recognised by antigranulocyte mouse monoclonal antibodies.

The distribution in paraffin fixed human tissues of a carbohydrate antigen defined by two monoclonal antibodies raised against human granulocytes has been studied by means of an immunoperoxidase technique. In addition to granulocytes, the antigen has been detected in adult tissues on identifiable cell types of the stomach, kidney, adrenal medulla, and brain and on the mucins of the gastrointestinal tract and other secretions. In fetal tissue, epithelial cells of the alimentary tract, lung, brain, and kidney express the antigen. Adenocarcinoma of the colon, stomach, breast, and lung are stained strongly, as are other types of lung cancer. The monoclonal antibodies give a staining pattern similar but not identical to other monoclonal antibodies raised against granulocytes or neoplastic cell lines which recognise the antigen 3-fucosyl N-acetyllactosamine. The use of antibodies against this oncofetal antigen in the study of differentiation and as tumour markers is discussed.

Adrenal Medulla↗
PubMed1984

Community assessment--a risk factor analysis.

An epidemiological model currently being used by graduate students in community health nursing for purposes of conducting an assessment and risk factor analysis has been presented. Data sets which were developed to reflect the four major health field categories have been found to be adequate for purposes of a risk factor analysis. As a result of the six-step process, students are able to identify "who" (i.e., which aggregates) in a community might be at high risk for specific health conditions and hypothesize "why" using risk factor data. The model has been beneficial as a guide for collecting and analyzing large amounts of information in a systematic fashion. Based on a risk factor analysis, health planning can be directed toward generating potentially alterable risk factors in particular health field elements. Such an approach has resulted in an orientation to population health which is characteristic of public health.

Community Health Nursing↗
PubMedDate not supplied

Characterization of a human granulocyte differentiation antigen (CDw15) commonly recognized by monoclonal antibodies.

Many different anti-human granulocyte monoclonal antibodies recognize the same carbohydrate antigen which contains the trisaccharide 3-fucosyl-N-acetyllactosamine. The antigen is expressed mainly on two cell surface glycoproteins of molecular weights around 105 K and 160 K which are apparently not members of the LFA-1 family of proteins. Although specific for granulocytes in blood, the antigen is expressed on a wide range of non-haemopoietic cell types.

Animals↗