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Biomedical subjects

N C Owen

Publications and source records attributed to N C Owen.

14 recordsLinked to original sources
PubMed1977

Haematological changes caused by Trichostrongylus colubriformis in lambs fed a dystrophogenic diet.

The effect of Trichostrongylus colubriformis on lambs maintained on a ration containing a low level of selenium and on animals receiving vitamin E and Se supplementation was investigated. The pathological changes seen in control animals slaughtered at the start of the experiment and in the animals which died during the course of the investigation revealed a high level of nutritional muscular dystrophy (NMD) in the lambs. There were no marked haematological changes in the control or infested sheep. Infestation was characterized by slight hypoalbuminaemia and gamma-globulinaemia. Serum levels of the enzymes AAT and CPK, which are important indicators of muscle necrosis and NMD, were greatly increased in sheep infested with T. colubriformis and not receiving supplementary Vit. E + Se. Data from this study therefore indicates that trichostrongylosis may aggravate the degree of muscle necrosis in lambs prone to the development of NMD.

Animals↗
PubMed1975

The choleretic action of Genebile in a dog.

A procedure for cannulating the bile duct of the dog is described. An intramuscular injection of Genebile increased the bile flow rate. A possible mechanism for this increase is suggested.

Animals↗
PubMed1975

The elimination of albumin, ployvinylpyrrollidone and dextran from the circulation in sheep.

The rates of elimination of iodinated human serum albumin (ALBUMIN-125I), polyvinylpyrrolidone (PVP-125I); and tritiated dextran (DEXTRAN - METHOXY-3H) (mol masses of 69 000 - 72 000, 30 000 - 40 000 and 60 000 - 90 000 respectively) from the circulation of sheep were studied; albumin and PVP initially disappeared from the circulation rapidly having half-life times (t 1/2) of 10,5 +/- 3,7 and 43 +/- 45 hours respectively. This phase is regarded as being due to equilibration within the initial volume of distribution, the rate being determined primarily by the relative mol. mass of the molecule. Hereafter PVP-125I was eliminated considerably faster (t 1/2 = 176 +/- 39 h) principally via the kidneys. The limited data available for dextran-3 H suggests that this particular substance is rapidly excreted via the kidneys (t 1/2 = 9 h).

Albumins↗