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Biomedical subjects

N C Woods

Publications and source records attributed to N C Woods.

5 recordsLinked to original sources
PubMed1985

Immunization of marmosets with Trypanosoma cruzi cell surface glycoprotein (GP90).

Marmosets (Callithrix jacchus) have been immunized with a vaccine comprising a Trypanosoma cruzi 90K cell surface glycoprotein and the adjuvant saponin; a combination previously shown to be protective in mice. Immunization was by two s.c. injections one month apart and non-lethal challenge of homologous Y strain T. cruzi was given one month after the booster immunization. No anti-T. cruzi antibodies were detected after the first immunization but high levels developed after boosting. Immunization caused a significant decrease in the levels of acute phase blood parasitaemia, however, both immunized and control animals remained xenodiagnosis positive 60 weeks after infection. No ECG aberrations, histopathological lesions or anti-tissue antibodies were detected in infected marmosets.

Adjuvants, Immunologic↗
PubMed1982

Renal function after acyclovir intravenous injection.

Plasma urea or creatinine was noted to be raised in 58 of 354 patients treated with intravenous acyclovir. This occurred after intravenous bolus injection of high dosages of acyclovir but the risk was considerably reduced by slow intravenous infusion of the same dosage over one hour, with adequate hydration of the patient and adjustment of dosage in patients with preexisting impaired renal function. Animal studies indicate that the impairment of renal function associated with high bolus injections of acyclovir is due to crystal formation in the renal tubules and/or the collecting ducts, and that the crystals are removed after cessation of treatment. The special problems involved in the treatment of patients with herpes encephalitis necessitating limited fluid intake and the possible interaction with other nephrotoxic drugs are discussed.

Acyclovir↗
PubMed1982

The efficacy of a novel compound, (e)-1-(4'-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene against Trypanosoma cruzi in mice.

The biological properties of a novel compound 353C with high activity against Trypanosoma cruzi, are described. The compound was about 10 times and 20 times more effective than either benznidazole or nifurtimox respectively, in producing radical cure in mice. 353C has a long half-life and showed anti-trypanosomal properties when given to mice at weekly intervals.

Animals↗
PubMed1980

Evidence for an immunological relationship between Streptococcus mutans and human cardiac tissue.

Two-dimensional immunoelectrophoresis, indirect immunofluorescence, and radioimmunoassay were used to demonstrate that antisera from rabbits immunized with some strains of Streptococcus mutans contain antibodies that cross-react with human cardiac tissue. These rabbits were sensitized to a shocking dose of human heart antigen, and anaphylactic deaths were sometimes produced. Myocarditis was also a result of the immunization procedure. Data obtained with all five techniques were comparable. Cross-reactivity could be associated with three antigens designated ID, IF, and HL. Antigens ID and IF were major immunogens of S. mutans Ingbritt, but HL antibodies were produced only after hyperimmunization. Corss-reactivity was of an immunological nature and not the result of nonspecific factors such as bacterial Fc reactive components or antibody elicited to growth medium constituents. These findings support the hypothesis that immunization with S. mutans can induce autoimmune reactions and indicate that antigens must be selected with caution before formulating any dental caries vaccine.

Anaphylaxis↗