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N Campanella

Publications and source records attributed to N Campanella.

At least 19 recordsLinked to original sources
PubMed2000

[The probability of assessing the pathogenesis of ischemic stroke. Study of 81 patients].

81 patients with ischemic stroke were studied in order to assess the pathogenesis, the accuracy of the pathogenetic diagnosis and the relationship between pathogenesis and infarct site. The pathogenetic mechanisms were grouped according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) system. TOAST system settles five pathogenetic diagnosis: 1) Large artery atherosclerosis (LM); 2) Cardioembolism (CE); 3) Small artery occlusion (SAO); 4) Other etiologies (SOE); 5) Undetermined pathogenesis. As regards the site, the patients were divided into the following groups: Posterior Circulation Infarcts (POCI) 8.6%, Total Anterior Circulation Infarcts (TACI) 19.8%, Partial Anterior Circulation Infarcts (PACI) 29.6%, Lacunar Anterior Circulation Infarcts (LACI) 30.9%, Multiple Site Infarcts 11.1%. A probable or certain diagnosis was issued only in 33.3%. The diagnosis was not complete in 22.2%. That was due either to the severe clinical status or the patient and his relatives' refusal. Most of the incomplete diagnosis occurred in TACI patients. The undetermined pathogenesis due to absent clues occurred in 18.5%. CE often brought about TACI, whereas LM was likely to provoke PACI. SOE, like systemic hypotension, brought about Multiple Site Infarcts. Unfortunately assessing the pathogenetic diagnosis is still a controversial issue and TOAST method itself is not satisfactory as an overall classification system.

Adult↗
PubMed2000

[Evaluation of the workload resulting from iatrogenic pathology in a medical ward in a regional hospital].

OBJECTIVES: 1) To estimate the burden to diagnose and treat iatrogenic disorders out of all the activities of a referral hospital's medical ward. 2) To investigate about the main causes making the iatrogenic disorders arouse. DESIGN AND SUBJECTS: The entire series of iatrogenic disorder bearing patients (in- and out-), treated in the Institute of Medical Pathology of Ancona throughout a period of two years, were studied retrospectively. The low therapeutic index treatments (i.e. antiproliferative drugs, therapies under emergency, surgical amputations) were ruled out. The data to address the objectives were gathered. RESULTS AND CONCLUSIONS: 1) Highly probable iatrogenic disorders were diagnosed in 84/1620 patients (5.2%). 2) For this task 108/2763 medical performances were carried out (3.9%); 3) iatrogenic disorders were Slight in 20 (24%), Moderate in 44 (52%) and Severe in 20 (24%) patients. 4) Some facilitaters (poor monitoring of adverse drug reactions, primary disease incorrect treatment, poor accuracy of primary disease diagnosis, incoordination among therapists) were detected in 32, 25, 14, and 7%. 5) The most commonly occurring facilitaters were detected more frequently in Severe rather than Non Severe iatrogenic disorder bearing patients. 6) Severe iatrogenic disorders and the serious consequences of them, such as death and permanent serious harm, occur more often, when there are combinations of facilitaters; 7) Costs were minor in 69% and major in 31%.

Hospital Units↗
PubMed1999

Paraneoplastic syndromes in 68 cases of resectable non-small cell lung carcinoma: can they help in early detection?

The aim of this study was to assess the importance of paraneoplastic syndromes as an early sign of non-small cell lung cancer (NSCLC). A procedure for searching paraneoplastic syndromes, based on 40 years of reports in the literature, was established and the prevalence of paraneoplastic syndromes estimated in 68 patients with resectable NSCLC. Stages I and II were considered eligible for surgery straight away. Patients in Stage IIIA underwent surgery if partially or completely responsive to three courses of neo-adjuvant chemotherapy. Paraneoplastic syndromes were assessed and confirmed in nine patients (13%). Motor-sensory neuropathy, arthritis and arthralgias to the knees, periarthritis to the shoulder, hypertrophic osteopathy, clubbing, pruritus were observed. Only three patients with painful osteoarthropathies were diagnosed with NSCLC by tracing their paraneoplastic syndrome, whereas most of them (36/68) were diagnosed incidentally through a chest radiograph taken for tumour-unrelated symptoms. A careful research of paraneoplastic syndromes in high risk patients may guide the doctor to a resectable NSCLC diagnosis. Recent onset arthritis and arthralgias, which cannot be explained otherwise, should be considered to be early clues of lung cancer.

Adult↗
PubMed1999

[The treatment of stroke in internal medicine wards or in an intensive care unit?].

The mortality and complication rates have been studied in a series of 92 patients with stroke, who have been treated in a general medicine ward in central Italy. The data have been compared and discussed in relationship with analogous parameters reported about some series from north-European stroke units (SU) and general medicine wards (RMG). The mortality rates have been 11% over the first 7 days and 18% over the first 30 days. In a series of patients from northern Europe these parameters have been 12 and 19%. In severe prognosis patients the complication rate has been 83%, whereas in the series from northern Europe it has been estimated 97%. The infectious diseases have been complicating stroke in 21% of the patients. This rate is as high as in SU's, but lower than in RMG (49%). In the over 65 patients the mean hospital stay has been 19 days versus 24 in the SU. The percentage of the patients dismissed home has been higher than in the SU and in the RMG. Taking into consideration only the above-mentioned short term parameters and the acute phase management, the SU do not apparently have any advantage in comparison to the general medicine ward in central Italy which has been considered for this study.

Aged↗
PubMed1999

Infectious diseases and natural disasters: the effects of Hurricane Mitch over Villanueva municipal area, Nicaragua.

BACKGROUND: A three month relief operation for the 25,303 people living in the municipal area of Villanueva, Nicaragua, hit by Hurricane Mitch, was carried out jointly by the staff of an international non-government organization and an Italian Regional Hospital's staff. METHODS: Health Mobile Teams joined the local health facilities (Health Centers and Health Posts) in responding to the people's urgent health problems. From their files the thirty-day post-disaster incidence of acute diarrheas (AD), respiratory tract infectious diseases (ARD), and malaria were estimated and compared with off-crisis data. New cases of leptospirosis were searched, but no control group was available. RESULTS: The incidence of AD and ARD increased significantly in comparison with pre-disaster data (6,798 vs. 2,849 per 100,000 inhabitants (p < 0.01) and 1,205 vs. 295 per 100,000 inhabitants (p < 0.01)). The increase in incidence of malaria was not explicit. Only three cases of leptospirosis were ascertained. The relief operators used the gathered data to make decisions to allocate the poorly available resources. CONCLUSIONS: The feasibility of the infectious disease surveillance and the reliability of the results under such conditions may change according to the setting. In this case study the infectious disease surveillance was feasible, and the gathered data were reliable and of some help to the relief operators in order to allocate the resources efficiently.

Chi-Square Distribution↗
PubMed1993

[A retrospective study of a patient population with benign thyroid pathology undergoing a partial thyroidectomy intervention].

1,196 consecutive cases were analyzed. The results show that familiarity is a major risk factor on goitre insurgence; minor risk factor is pregnancy. The most frequent thyroid disease in pregnancy is the lymphocytic chronic thyroiditis; if the women have familiarity for thyroid disease the probability to display a thyroid disease in pregnancy is most augmented. Thyroid scintigraphy shows its elevated sensitivity: only in someone thyroid adenomas a difference occurs between scintigraphic imaging and surgical-anatomical presentation. Antimicrosomal antibodies relief presents highest utility in autoimmune thyropathies.

Antibodies↗
PubMed1990

[Follow-up of a population of patients who underwent partial thyroidectomy for benign thyroid pathology].

Natural history of partial thyroidectomy for thyroid disease has been studied in a population of 1196 consecutive cases surgically treated from 1977 to 1982. Follow-up analysis on this population (from six to eleven years) was carried out for appearance of recurrence. Generally, the recurrence incidence was small (only 9.9% of total population) but high frequency was observed for Graves' disease (46%) and lymphocytic chronic thyroiditis (21%). The substitutive/suppressive therapy administration did not influence recurrence of disease. Our results suggest that suppressive therapy does not modify the natural course of non cancerous thyroid pathology residual to partial thyroidectomy.

Adenoma↗
PubMed1985

[Growth hormone after baclofen in normal and acromegalic subjects].

Serum growth hormone (GH) levels in basal conditions (two samples) and 30, 60, 90, 120, 150 and 180 minutes after oral administration of baclofen (20 mg) were evaluated in 6 healthy subjects and in 6 acromegalic patients. The effect of cimetidine (400 mg i.v.) administrated 45 minutes after baclofen (20 mg by mouth) were evaluated in 9 healthy women. Baclofen was able to significantly rise serum GH levels in normal subjects but no in acromegalic patients. Cimetidine suppress GH increase induced by baclofen. It was concluded that: 1) baclofen, GABAb receptor agonist, stimulate GH secretion by inhibition of GIF secretion or by stimulation of GRF secretion; 2) istamine, through H2 receptors in the hypothalamus, is important to mediate GH release induced by stimulation of GABAb receptors.

Acromegaly↗
PubMed1984

[Neurohypophyseal diabetes insipidus. Anatomo-clinical correlations].

Eighteen patients aged between 14 and 60 years suffering from diabetes insipidus were studied. Diabetes insipidus was diagnosed by means of Robertson's test. All patients underwent C.T. scanning and evaluation of PRL basally and after TRH (200 mcg e.v.). Twelve patients (66%) showed neurological lesions (secondary central diabetes insipidus). Six of these patients had hyperprolactinaemia. Our data suggest that most of central diabetes insipidus are associated with central system nervous (S.N.C.) damage. In same cases the presence of hyperprolactinaemia suggests a brain damage. Therefore neuroradiological study is very important in all cases of neurohypophyseal diabetes insipidus.

Adolescent↗
PubMed1984

[Evaluation of TSH secretion after GnRh in patients with primary hypothyroidism].

6 women (mean age 38 years) with high Thyroid Stimulating Hormone (TSH) serum levels because affected from primary hypothyroidism were studied. 6 healthy women (mean age 31 years) represented the control group. All subjects underwent evaluation of serum TSH, Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), basally and 20, 30, 60, 120 minutes after administration of Gonadotropin Releasing Hormone (GnRH: 100 meg. IV). Seric FSH and LH show a large increase 30 minutes after GnRH either in healthy or in hypothyroid subjects. TSH is unresponsive to GnRH in normal condition, while shows a clear decrease (-78%) 30 minutes after GnRH in primary hypothyroidism. Rarely the hypothalamic releasing hormones possess an inhibitory effect on anteipophyseal secretions. Previously a GnRH inhibitory effect on prolactin (PRL) release from PRL secreting tumors in rat. The GnRH inhibitory effect on TSH release in pathological conditions such as primary hypothyroidism is difficult to explain: it may be that GnRH acts on Central Nervous System or at pituitary level: in the last case it could bind sites which are not quite different in the different glycoprotein secreting cells.

Adult↗
PubMed1981

[GH after baclofen and diazepam].

It has been proposed that GABAergic receptors possess two functionally distinct, but strictly co-operating binding sites, one for GABA itself, another for benzodiazepines. The activation of GABA receptor is followed by opening of the Cl- channels. This action is strengthened if both binding sites of GABA receptor are contemporaneously engaged by their respective agonists. Baclofen, a GABAergic drug, is able, in acute administration, to determine an increase of serum GH in man. The aim of this work was to control if benzodiazepines can strengthen this metabolic effect of Baclofen in vivo. Five healthy voluntary women were studied. Blood samples for serum GH evaluation were collected basally and 30, 60, 90, 120, 150, 180, 210 minutes after oral administration of 20 mg. of Baclofen. This test was repeated one week after oral administration of 12 mg. die of Diazepam. The results were analyzed for paired data. The finding show that the metabolic effect of Baclofen on GH secretion are prolonged in time after Diazepam premedication and suggest that GABA-benzodiazepines interaction is effective at hypothalamo-hypophyseal level in man.

Baclofen↗