Biomedical subjects

N Capstick

Publications and source records attributed to N Capstick.

12 recordsLinked to original sources

PubMed1980

Long-term fluphenazine decanoate maintenance dosage requirements of chronic schizophrenic patients.

Forty-seven schizophrenic out-patients, who were satisfactorily maintained on a depot injection of fluphenazine decanoate, and who received the injection every 28 days, were progressively withdrawn from medication by increasing the time interval between injections while maintaining the amount of of drug per injection. The rate of reduction varied with each patient depending on various factors such as environmental stress considerations, and the patient's wishes. Finally three injections at 8-weekly intervals were given before complete withdrawal. The follow-up period was 23.7 months with a standard deviation of 1.9. A relapse rate of 80% was found, 25 patients relapsing during the withdrawal phase and 22 patients after the drug had been completely withdrawn.

Adult↗

PubMed1977

Obsessional stat es. A study in the relationship between abnormalities occurring at the time of birth and the subsequent development of obsessional symptoms.

The purpose of this study was to examine the theory that there is a positive relationship between the occurrence of abnormalities at the time of birth and the subsequent development of obsessional states. While an abnormal birth may result in minimal brain damage this is not necessarily the significant factor, as a separation of mother and baby in the immediate neonatal period, Which usually follows an abnormal birth, may be of more relevance. Observations are made on certain phenomenological aspects on obsessions in patients who give a history of abnormal birth as compared with those patients who have obsessional states and give a normal birth history. In the discussion comments are made upon the separation anxiety theory as being an important aetiological factor in the obsessional neurotic state.

Anxiety, Separation↗

PubMed1977

Clinical experience in the treatment of obsessional states (1).

This paper describes the treatment of thirty-three patients who were suffering with obsessional symptoms and who were given the drug clomipramine (Anafranil, Geigy Pharmaceuticals). The symptoms were classified into phobic ruminations, non-phobic ruminations and rituals as well as into the less familiar group of normal and bizarre obsessions. Progress was assessed using the Shapiro card method and a brief description of this method is given. The results show that clomipramine possesses a specific anti-obsessional quality and that the use of this preparation is an effective treatment for obsessional patients. The paper also discusses certain aspects of therapy as well as suggesting an aetiological basis of obsessional symptoms.

Adult↗

PubMed1976

A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy.

A trial involving patients receiving fluphenazine decanoate was designed to compare the effects of orphenadrine hydrochloride (Disipal) and its major metabolite, tofenacin hydrochloride (Elamol) on the Parkinsonian side-effects and depression occurring during fluphenazine decanoate therapy. The trial was a double-blind one, with crossover. It was found that both drugs exerted an adequate control on the Parkinsonian side-effects, but there was no significant difference between their effects. Ophenadrine, however, was shown to be significantly superior (p less than 0-05) in the control of the depressive side-effects.

Clinical Trials as Topic↗

PubMed1975

Clomipramine in the treatment of the true obsessional state. A report on four patients.

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Adult↗

PubMed1975

The Shapiro cards scale as a method of assessment of obsessional symptoms in clomipramine therapy.

One of the major problems encountered in research into the value of a new treatment for obsessional states is the small number of patients seen in any one centre. Another problem is the great diversity of symptoms which obsessional patients display. These two problems may be partly overcome by the use of the method of rating devised by Shapiro. The technique is described and its application to the treatment of obsessional disorders illustrated.

Adult↗

PubMed1975

Depressive reactions in the course of clomipramine therapy used in the treatment of obsessional conditions.

In a small series of patients, suffering from obsessional disorders, it was found that there seems to be a type of depression which occurs during the course of clomipramine therapy. As clomipramine is an antidepressant, this may seem to be an anomaly but it is suggested that depression is secondary to agitation and tension which are recognised side-effects of clomipramine. The patients nevertheless showed improvement in their obsessional symptomatology. The finding seems to reinforce the view that clomipramine has an antiobsessional effect which is distinct from its antidepressant property.

Adult↗

PubMed1973