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N Chatterjee

Publications and source records attributed to N Chatterjee.

48 records · Page 3Linked to original sources
PubMed1993

A birth control vaccine is on the horizon for family planning.

Vaccines for control of fertility are likely to have an important impact on family planning methods. They are designed to act by mobilization of an internal physiological process and do not require external medication on a continuous basis. A number of birth control vaccines are at different stages of development, the most advanced being a vaccine inducing antibodies against human chorionic gonadotrophin (hCG). This vaccine consists of a heterospecies dimer (HSD, beta hCG associated with alpha-subunit of ovine luteinizing hormone, beta hCG:alpha oLH) linked to tetanus toxoid (TT) or diphtheria toxoid (DT) as carriers. The vaccine has recently passed an important milestone; it has completed the first leg of phase II efficacy trials. Women of proven fertility leading active sexual life were protected from becoming pregnant at antibody titres > or = 50 ng of hCG bioneutralization capacity per ml. This vaccine has previously been demonstrated to be reversible in its effect. It is free from any notable side-effects on endocrine, cardiovascular and other body functions. Ovulation was not disturbed and menstrual regularity was maintained. A logistic disadvantage of the present vaccine is the requirement for multiple injections. This is expected to be overcome by encapsulation of the requisite doses of the vaccine in biodegradable microspheres, which could be given at a single contact point for sustained antibody titres lasting over a year. A live recombinant vaccine has also been made that elicits high anti-hCG titres in monkeys for nearly 2 years following primary immunization and a booster at 8-9 months.

Adult↗
PubMed1992

Vaccines for control of fertility and hormone dependent cancers.

Two vaccines, namely one inducing antibodies against hCG and the other against GnRH, are now in clinical trials. The hCG vaccine has entered Phase II clinical trials in three centres in India after successfully completing Phase I clinical studies in several centres in India and in four countries abroad. The vaccine was found to be devoid of side-effects; its effect was reversible. The available data on 179 cycles indicate that the vaccine prevents pregnancy at antibody titres above 50 ng/ml. A genetically engineered version of the vaccine has also been approved for trials in human lung cancer patients of the type which make hCG. hCG is observed to be a growth factor for such tumours. The GnRH vaccine is usable in both males and females as the deca-peptide is common to both sexes. Following suitable experimental and toxicology studies, the vaccine is currently in Phase I/Phase II clinical trials in patients of prostate carcinoma. Where antibody GnRH antibodies were induced, the LH, FSH and testosterone levels declined. This was accompanied by a reduction in prostate specific antigen. Clinical improvement was observed in many cases. The vaccine has also entered Phase I clinical studies in postpartum women, with the objective to extend the lactational amenorrhoea and extend inter-child interval.

Chorionic Gonadotropin↗
PubMed1992

Anti-hCG vaccines are in clinical trials.

Two vaccines inducing antibodies against human chorionic gonadotropin (hCG) have completed Phase I clinical trials, indicating the reversibility and safety of these vaccines. One is currently in Phase II efficacy trials in women in three major centres in India. The available data suggest that the vaccine prevents pregnancy above antibody titres of 50 ng/ml hCG bioneutralization capacity.

Antibodies↗
PubMed1983

Difference between tortoise and hen lysozymes in the mode of association with N-acetyl D-glucosamine as revealed by proton magnetic resonance spectroscopy.

Tortoise lysozyme, unlike hen lysozyme, does not distinguish between the alpha- and beta-anomeric forms of N-acetyl D-glucosamine. This indicates that alpha- and beta-anomeric forms of the inhibitor have the same affinities and experience identical magnetic environments in tortoise lysozyme. The dissociation constant of tortoise lysozyme-inhibitor complex was calculated from chemical shift data and found to be 3.5 X 10(-2) M. The enthalpy of dissociation was calculated to be 5.0 kcal/mol.

Acetylglucosamine↗
PubMed1980

Pre-menstrual tension and mood change.

Pre-menstrual tension has been studied intensively for many years. A review of relevant literature was undertaken to try to clarify the admixture of fact and fiction which has accumulated. The bulk of research noted has been done using self-reporting scales of physiological and psychological discomfort. This research has been criticized on methodological grounds. There seems little question that mood changes do occur during the menstrual cycle. It would appear that, irrespective of personality factors and psychopatholoy, such changes can be correlated with levels of progesterone and estrogen. Gonadal hormones affect cerebral MAO levels and catecholamine metabolism. High levels of estrogen have been related to increased feelings of well-being and low levels of depression. Studies have attempted to explain differences in menstrual mood changes to the psychological impact this process may have. While this cannot be discounted, it is likely that there is an interaction between psychological and physiological factors. Clarification of this is an important challenge for future research.

Affect↗
PubMed1978

Cytomegalovirus infections in renal allograft recipients: correlative studies with histocompatibility antigens.

We studied 32 renal allograft recipients in order to determine whether or not any correlation could be demonstrated between the HLA and development of cytomegalovirus infection. There was a positive stastical correlation (P less than 0.01) of the development of cytomegaloviraemia and the number of HLA antigens mismatched in the recipient. There was no correlation between specific HLA antigens and predisposition to develop cytomegalovirus infection. The implication of our observations with regard to the pathogenesis of cytomegalovirus infection in renal allograft recipients is discussed.

Adult↗