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Biomedical subjects

N Cikes

Publications and source records attributed to N Cikes.

At least 37 records · Page 2Linked to original sources
PubMedDate not supplied

[Hospitalization for systemic connective tissue diseases in Croatia in 1997: examples of the use of hospital morbidity registery data bases].

By using the explanatory analysis methods, we examined a possible model for the utilization of the Croatian Hospital Morbidity Register data for decision making in the managerial process for national health system development. To build a draft informational model, data were selected on 843 cases hospitalized in 1997 for diseases M30-M36 (ICD-10) in 45 health institutions. This was used as an index of the diagnostically/therapeutically most demanding group of rheumatic autoimmune diseases. Treatment standards were established for our health system for the patients having an M30-M36 disease by classifying Croatia's health institutions into four clusters by intensity of hospitalization, and by analyzing demographic characteristics and the length of stay by disease entity. These standards could represent a good informational base for forming consensus group panels to deal with inpatient treatment problems of patients with systemic connective tissue diseases.

Adolescent↗
PubMedDate not supplied

[Tuberculosis in systemic connective tissue diseases].

Six female patients who developed tuberculosis during the treatment of connective tissue diseases are presented. Underlying disease--systemic lupus erythematosus, rheumatoid arthritis, and polymyositis--with its numerous immunopathologic processes essentially decreases resistance of the organism to infections. Tuberculosis usually accompanies chronic, exhausting diseases and tends to involve patients with the decreased immunity. The use of glucocorticoids and immunosuppressive agents has been shown to have a significant influence on the suppression of the immune system. Thus, tuberculosis is a dangerous, very often fatal complication in the course and treatment of connective tissue diseases.

Adult↗
PubMedDate not supplied

[Analysis of the flow of medical information from Croatia into the world].

It is commonly thought that an article published in a renown international journal gives its authors better chances for visibility. The present paper aims at answering three questions: (a) does an article published in a top international journal guarantee that its authors will be visible, (b) is an article published in a domestic journal (not covered by ISI) completely inaccessible to the international public, and (c) which are the information flows and how far does the medical information from Croatia reach. Selected was a corpus of 60 authors, who simultaneously publish in foreign journals and in Lijecnicki vjesnik (LV). The corpus consists of 1053 articles published in the 1961-1986 period. Out of these, 369 articles were published in LV and 684 in foreign journals; 177 among them are covered by the Science Citation Index. A total of 4481 citations were collected for the entire corpus of 1053 articles. The citations pertain to 506 articles, i.e. 48% of articles were cited. There are 190 cited and 83 uncited journals. The citations were distributed among 890 journals. Although the studied authors published their papers in renown international journals, a number of examples proves that this does not guarantee their visibility. An article published in LV need not necessarily remain inaccessible to the world--this depends on the article itself. The present analysis provides a compendious insight into the transfer of information from Croatia into the world. The data from citation analysis enable the deduction of "average number of citations per paper". With an appropriate interpretation it can be used as an indicator of information transfer.

Bibliometrics↗
PubMedDate not supplied

[Cellular immunity and the autoantibody system in polymyositis and dermatomyositis].

Polymyositis and dermatomyositis are clinical forms of inflammatory muscle diseases of unknown etiology. Cellular immunity seems to have great importance in pathogenesis of the idiopathic inflammatory myopathy. It is well known that specifically sensitised lymphocytes from the peripheral blood of patients with polymyositis and dermatomyositis may secrete various mediators (e. g. lymphokines) and be cytotoxic to muscle cell tissue culture as well. In recent years, a variety of anti-muscle antibodies and antibodies to nuclear and cytoplasmic antigens have been identified in the serum of patients with idiopathic inflammatory muscle disease, but their role in this clinical syndrome is still unknown. In this review article authors bring out some of the current state of knowledge about polymyositis and dermatomyositis related autoantibody systems, including biochemical characteristics of the target antigens, epidemiological and clinical significance, and possible role of these autoantibodies in the development of the disease.

Autoantibodies↗
PubMedDate not supplied

[The mastocytosis syndrome].

A female patient with the history and clinical signs suggesting cutaneous and systemic mastocytosis is reported. The diagnosis of cutaneous mastocytosis was confirmed by the Darier's sign as well as by histologic analysis of the skin. An X-ray film of the bones showed an infiltration of the mast cells into the skeletal system what was also cytologically and histologically proven. The patient was treated only symptomatically because of the benign course of the disease. A current literature data on mastocytosis syndrome are discussed.

Female↗
PubMedDate not supplied

[Clinical importance of antinuclear antibodies].

Determination of antinuclear antibodies in the sera of patients with multisystem connective tissue disease has a long clinical application. In the review article authors report on their clinical significance and describe the types of antinuclear antibodies; anti-DNA antibodies, antihistone antibodies, anti-RNA-protein complexes and other antinuclear antibodies. The methods of laboratory determination of antibody types are discussed as well as their application in the diagnosis of autoimmune and multisystem-rheumatic diseases.

Antibodies, Antinuclear↗