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Biomedical subjects

N Cochrane

Publications and source records attributed to N Cochrane.

9 recordsLinked to original sources

Physical contact experience and depression.

Out of a consideration of the relevance of interpersonal physical contact to mental health is developed the hypothesis that unsatisfactory physical contact experience predisposes to depression. This hypothesis is then systematically explored using self-ratings of depression and physical contact (and love) experience obtained on admission and at discharge from 254 unselected psychiatric in-patients. Following the demonstration of a strong association between unsatisfactory physical contact experience and depression a significant relationship is also found between depression and the experience of being not loved. These two relationships are shown to exist independently of one another and when direction of causation is investigated both unsatisfactory physical contact experience and the experience of being not loved are seen to be causal of depression rather than vice versa. Unsatisfactory physical contact experience, however, clearly has the greater utility as an indicator of depression-proneness. Different categories and different kinds of physical contact experience are explored, first in relation to depression generally and then to each of the three major forms of depressive illness. Considered too is the patterning of physical contact experience and love experience for each of these latter. The results suggest that depression generally tends to be more closely linked with stable than unstable unsatisfactory physical contact experience and with present rather than childhood such experience. In addition endogenous depression is seen to be characterised by an absence of any physical contact experience in the present, while manic-depressive psychosis combines unsatisfactory physical contact experience with the experience of being loved and shows a relative lack of exclusively bad physical contact experience in childhood. Reactive depression, however, emerges with no distinguishing features of this kind. There follows an examination of the relationships between unsatisfactory physical contact experience and those psychiatric conditions other than depression represented in the subject sample. This raises the possibility that unsatisfactory physical contact experience could also be closely linked with schizophreniform disorder and adjustment disorder. Finally it is suggested that, above all, physical contact experience may be a major determinant of the capacity to cope with stress. Unsatisfactory such experience might then be predisposing to a wide range of psychiatric disorders, with depression seen as a commonly occurring symptom of inadequate coping.

Adaptation, Psychological↗

The effects on personality of open prefrontal leucotomy.

The Sixteen Personality Factor Test was administered to 28 patients both before and six months after they received open prefrontal leucotomies. The preoperative and postoperative test results are compared. Preoperatively the group was excessively apprehensive, tense, affected by feelings, sober, shy, and humble. After leucotomy these aspects of personality all showed significant change in the direction of normality. With the exception of the humble versus assertive aspect, however, the mean scores in each case remained outside the normal range.

Adult↗

The effects on intellectual functioning of open prefrontal leucotomy.

The Wechsler Adult Intelligence Scale and the Wechsler Memory Scale were administered to 32 patients both before and six months after they received open prefrontal leucotomies. The preoperative and postoperative test results are compared, consideration being given to individual patients as well as to the group. The mean results for the group provide no evidence of any post-operative intellectual deterioration. However, it seems probable that in individual cases such deterioration occurred. In most of these cases brain damage would appear to be responsible, and the ability "to comprehend and size up a total situation" is seen as the area of functioning primarily affected.

Adult↗

Depressive illness: the role of aggression further considered.

Measures of depression and undischarged drive were obtained for 292 psychiatric in-patients. In 200 of these cases inhibition of aggression was also assessed. All patients were classified as being endogenously depressed, reactively depressed, or as suffering from non-depressive primary disorders. The latter group was subdivided into secondarily depressed and non-depressed groups. The 3 depressed groups were then compared with the non-depressed subjects in respect of drive level and inhibition of aggressionmall 3 depressed groups showed significantly higher driver level than did the non-depressed subjects. The endogenous depressives also inhibited significantly more of their aggression than did the non-depressed subjects. The results are consistent with a drive inhibition theory of depression. However, while endogenous depression seems to be associated more specifically with the inhibition of aggression, reactive depression may be associated rather with the inhibition of drive generally.

Adjustment Disorders↗

A prospective evaluation of open prefrontal leucotomy.

Forty-three patients received an open prefrontal leucotomy for severe and intractable psychiatric illnesses. As a result of the operation three patients died, three developed personality changes and one had repeated grand-mal seizures. Of the 40 patients followed up for six months, 57-5% showed marked improvement in their clinical state and 30-0% mild to moderate degrees of improvement whilst no patient's condition was considered to be worse. Significant improvement was obtained after operation in the mean scores on the Hamilton Anxiety Scale, the Hamilton Depression Scale, the Beck Depression Scale and the Neuroticism Scale of the Eysenck Personality Inventory. Extroversion, as measured by the Eysenck Personality Inventory, was significantly increased after operation. It is recommended that open prefrontal leucotomy procedures be replaced by the safer stereotactic or electrode implantation techniques and that all psychosurgery be confined to specialist units.

Adult↗