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Biomedical subjects

N Colbert

Publications and source records attributed to N Colbert.

28 records · Page 2Linked to original sources
PubMed1983

Hyponatremia associated with angioimmunoblastic lymphadenopathy.

Angioimmunoblastic lymphadenopathy (AIL) is a lympho-proliferative disorder whose clinical and histological features are now well recognized. Up to now, no attention has been focused on electrolytic disturbances associated with AIL. We report 12 cases of AIL with hyponatremia below 130 mmol/l on admission. Clinical and biological features suggest that hyponatremia of AIL is dilutional and related to plasma volume expansion. The mechanism of these hydro-electrolytic disturbances is unclear.

Humans↗
PubMed1983

Adrenocorticotropic hormone in the prevention of cisplatin-induced nausea and vomiting.

A double-blind trial to evaluate the antiemetic effects of adrenocorticotropic hormone (ACTH) in patients treated with cisplatin was performed. Thirty-seven adults with advanced cancer who were treated with cisplatin were randomly assigned to receive either synthetic long-acting ACTH (1 mg IM given 24 hours, 12 hours, and immediately preceding the administration of cisplatin) or a placebo given under the same conditions. All of the patients received chlorpromazine (50 mg IM) 30 minutes before cisplatin infusion. Patients receiving ACTH and chlorpromazine had significantly fewer episodes of vomiting (p less than 0.01) and shorter periods of nausea (p less than 0.02) than patients receiving placebo and chlorpromazine. Patients receiving ACTH and chlorpromazine were significantly more comfortable than patients receiving placebo and chlorpromazine. No important side effects were observed. ACTH may be an effective agent in preventing nausea and vomiting induced by cisplatin.

Adrenocorticotropic Hormone↗
PubMed1983

[Multiple myeloma manifested by plasmocytic laryngeal localization].

Multiple myelomas are very rarely accompanied by extramedullary collections of plasma cells. The authors report the exceptional case of a multiple myeloma which was revealed by a sub-glottal localization of plasma cells. This case illustrates the difficulties of interpretation of histological examinations and the value of tissue immuno-fluorescence for confirmation of the diagnosis.

Female↗
PubMed1982

[Denutrition of cancer patients].

Denutrition of cancer patients is a complex phenomenon involving inadequate calorie uptake from anorexia and metabolic disorders. The malignancy itself is the source of excessive energetic expenditure secondary to little known biological disturbances. Several effects of cytostatic drugs also contribute to nutritional imbalance. The need for re-establishing nutritional balance becomes obvious when the detrimental consequences of denutrition (particularly as regards immune defence mechanisms) are borne in mind. Nutritional requirements can be accurately determined by means of repeated simultaneous analysis of simple data. When oral feeding, even supplemented, appears insufficient, artificial feeding is capable of reducing, at least partly, the nutritional deficiency, improving the patient's comfort, lowering the incidence of infections and improving tolerance of cytostatic drugs. The effects of artificial feeding on response to these drugs have not yet been clearly established. Continuous enteral feeding deserves to be revalorized; it should be preferred to parenteral feeding when digestive functions remain satisfactory.

Anorexia↗
PubMed1981

[A rare cause of acute respiratory distress syndrome in adults: acute disseminated pulmonary tuberculosis. Four cases (author's transl)].

Four cases of acute respiratory distress syndrome due to miliary tuberculosis are reported. All four patients had tuberculin anergy; three developed disseminated intravascular coagulation. All were treated early with anti-tuberculous drugs. Three patients were intubated and ventilated with positive end expiratory pressure, but they died shortly afterwards. The fourth patient was treated with continuous positive airway pressure and corticosteroids and survived. In view of such reports, the possibility of tuberculosis should be considered systematically in all adult patients with unexplained acute respiratory distress syndrome. The extremely rapid course of the disease and the inconsistent results of standard examinations for tuberculosis justify an "aggressive" diagnostic approach. Extra-pulmonary biopsies, notably of the bone marrow, are very helpful.

Acute Disease↗
PubMed1980

[Acute leukaemia during pregnancy: favourable course of pregnancy in two patients treated with cytosine arabinoside and anthracyclines (author's transl)].

A report of two cases of acute leukaemia discovered during pregnancy. The first was treated from the 24th week with cytosine arabinoside, daunorubicine and vincristine and then rubidazone. Only an incomplete remission was obtained. The pregnancy ended with the birth at the 36th week of a normal child, which remains well at the age of 13 months. The second patient received during the 29th week of pregnancy chemotherapy combining cytosine arabinoside and daunorubicine. Signs of foetal distress appeared at 31 weeks. Delivery took place during the 33rd week in a phase of aplasia. The child was born apparently dead and was resuscitated. A complete remission of the leukaemia was obtained. The child was well at the age of 13 months. A transient neutropaenia was noted at the age of 2 months in both children.

Adult↗
PubMed1979

A new translocation in Burkitt's tumor cells.

A t(8;22)(q24;q11) translocation was found in blood, bone marrow, and ascites cells from a European Burkitt's lymphoma. Cell surface markers were identified as monoclonal IgG. The relationship between these two unusual findings is questionable in this cytologically typical Burkitt's lymphoma.

Aged↗
PubMedDate not supplied

[Hepatic chemotherapy by hepatic arterial catheterization with an implantable system allowing permanent vascular access].

This technique of anti-cancer treatment of hepatic cancers has a twofold interest: it delivers local chemotherapy in direct contact with the tumours and it allows repeated access to the blood supply of the liver without the need for surgery. This second point is particularly emphasized in the form of a technical description of the method of approach to the hepatic arterial system, which is as non-aggressive as possible and which allows permanent vascular access. This study, which required close collaboration between the departments of Vascular Radiology, Radiotherapy and Surgery, was initially considered as a feasibility study of a technique enabling the simple use of implantable vascular access sites.

Antineoplastic Agents↗