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N D Aggarwal

Publications and source records attributed to N D Aggarwal.

8 recordsLinked to original sources
PubMed1986

A survey of osteoporosis using the calcaneum as an index.

Two hundred radiographs of the calcaneum and 200 radiographs of the femoral neck from 100 persons were compared. A system of calcaneal grading, different from that earlier reported, was evolved which correlated significantly with the Singh Index. We found that resorption of secondary tensile and compressive trabeculae occurred before resorption of the primary trabeculae. Interruption of primary compressive trabeculae, which was previously described, is an inconstant feature. Our system using six grades is easier to correlate with the Singh Index. We found that osteoporosis increased progressively with age and was three times more common in females than males.

Adult↗
PubMed1978

Synthesis and biological activity of cocaine analogs I: N-alkylated norcocaine derivatives.

N-Allylnorcocaine, N-dimethylallylnorcocaine, and N-cyclopropylmethylnorcocaine were prepared and examined for cocaine-like activity. The compounds were prepared by alkylation of norcocaine, which was obtained by demethylation of cocaine with 2,2,2-trichloroethyl chloroformate followed by zinc--acetic acid reduction. The compounds were evaluated by comparison with cocaine in causing disruption of milk intake in rats, behavioral modification in squirrel monkeys, and inhibition of 3H-serotonin uptake by rat synaptosomes. The compounds showed cocaine-like activity less potent than cocaine in the latter two tests and were inactive in the milk intake test.

Animals↗