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N D Chapman

Publications and source records attributed to N D Chapman.

9 recordsLinked to original sources
PubMed1990

A comparison of mebeverine with high-fibre dietary advice and mebeverine plus ispaghula in the treatment of irritable bowel syndrome: an open, prospectively randomised, parallel group study.

OBJECTIVE To compare the efficacy and acceptability of mebeverine and high-fibre dietary advice versus mebeverine and ispaghula in fixed combination in the treatment of irritable bowel syndrome in adults. DESIGN Open, prospectively randomised, parallel group comparison of mebeverine/dietary advice and mebeverine/ispaghula during an eight-week study period. SETTING General practices in the UK. PATIENTS One hundred and eleven patients with irritable bowel syndrome diagnosed by symptom profile or negative investigations between the ages of 18 and 75 years were entered. All patients had a history of abdominal pain occurring at least once a week for a period of three months or more. INTERVENTION Dosage was 135 mg of mebeverine hydrochloride, three times daily before meals, together with advice on high-fibre dietary intake, or 135 mg of mebeverine hydrochloride plus 3.5 g of ispaghula husk twice or three times daily before meals. MEASUREMENTS AND RESULTS Details of abdominal pain severity and frequency, bowel frequency and stool consistency were recorded by means of clinicians' assessments and patient diaries. Pre-treatment assessments revealed no significant differences between the two groups with respect to any of the parameters. Both treatment groups demonstrated highly significant improvements in the numbers of pain attacks and their severity; no statistically significant differences between the two groups were demonstrated. Five patients in the mebeverine/dietary advice group reported five concurrent effects and nine patients in the mebeverine/ispaghula group reported 13 concurrent effects. All of the mebeverine/dietary advice group found their treatment acceptable but up to 28% of the mebeverine/ispaghula group found their treatment unpalatable. CONCLUSION Both treatments are effective in the treatment of irritable bowel syndrome in adults. The fixed combination of mebeverine/ispaghula, however, was found to be unpalatable by up to 28% of the patients in that group. There does not, therefore, appear to be any advantage in using fixed combination therapy in this condition.

Adolescent↗
PubMed1989

An open multiple dose study of Optrex Eye Lotion in eye irritation due to hayfever.

Twenty-four patients consulting their general practitioner with eye irritation due to hayfever entered a seven-day open, multiple dose study of a newly formulated Optrex Eye Lotion. Patients self-administered Optrex by irrigation into their left eye three times daily for seven days, with an option to use the same preparation in their right eye if they thought this to be of benefit. Assessment was by means of daily diary cards completed by the patient each evening for the seven-day period. Following the first instillation, the treated eye felt significantly better at 20 seconds and at four minutes when compared with the untreated eye. Differences between the eyes for degree of redness, comfort and clearness of vision were not significant, but 15 patients (63 per cent) optionally used Optrex in their right eye. Seventeen patients (71 per cent) reported that they derived overall benefit from the use of Optrex Eye Lotion during the study period. Two patients reported side effects during the study but, in each case, the investigator did not consider the event to be therapy related. One patient withdrew on Day 7 of the trial due to worsening of their allergic conjunctivitis. It can be concluded that some subjective benefit was gained by the majority of patients in that a considerable number of them chose to treat both eyes for the duration of the study.

Administration, Topical↗
PubMed1966

Routine.

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Nursing↗
PubMedDate not supplied

Triazine and chloroacetamide herbicides in Sydenham River water and municipal drinking water, Dresden, Ontario, Canada, 1981-1987.

Samples of raw river water from the Sydemham River, Ontario were collected 30 to 50 times per year between 1981 and 1987 along with paired samples of drinking water from the town of Dresden. Atrazine and its metabolite, deethyl atrazine, were found in 89 to 100% of the raw water over the seven year period. Alachlor was found only in 1982, 1984 and 1985 when 2 to 17% of raw waters were contaminated. Cancellation of the registration to use alachlor at the end of 1985 resulted in no residues being found in 1986 and 1987. Cyanazine was found in 3 to 29% (1982-87), metolachlor in 19 to 27% (1984-87) and metribuzin in 2 to 7% (1982-86) of raw river water. Comparison of those residues in raw with those in drinking water revealed that chlorination of river water had no effect in reducing herbicide concentrations. During 1985 the addition of up to 50 mg/L of powdered charcoal to raw water reduced residues to near or below detection limits for s-traizine and chloroacetamide herbicides. However, in 1986, with a reduced rate of 20 mg/L of charcoal herbicide residues were only slightly reduced and in 1987 with only 5 mg/L no reductions occurred.

Acetamides↗