PubMed Health⌕ Search

Biomedical subjects

N D Eshchenko

Publications and source records attributed to N D Eshchenko.

23 records · Page 2Linked to original sources
PubMedDate not supplied

[Participation of thyroxine in the regulation of the rate of isocitrate dehydrogenase reactions in the brain and liver].

A study was made of the effect of thyroxin on the activity of NAD- and NADP-dependent isocitratedehydrogenases in the brain and the liver of chick embryos. It was found that in both of the organs thyroxin accelerated isocitrate oxidation in the mitochondria through the NAD-dependent route and elevated the velocity of the NADP-isocitratedehydrogenase reaction in the citoplasm. At the same time the activity of the mitochondrial NADP-dependent isocitratedehydrogenase increased after the administration of the hormone to the embryos only in the mitochondria of the brain cells; this was apparently associated with the intensive biosynthesis of specific lipids in the developing brain. There was noted a more marked change in the activity of the enzymes in the 18-day embryos, in comparison with the 12-day ones.

Age Factors↗
PubMedDate not supplied

[Change in the tricarboxylic acid cycle dehydrogenase activity under the action of thyroxine in the brain of animals of varying age].

The effect of thyroxin on the activities of tricarboxylic acid cycle enzymes and NADP-malate dehydrogenase in the rat brain was studied. Experiments were conducted on 20- and 40-day old and on adult rats. Injection of L-thyroxin (50 microgram/100 g body weight) to thyroidectomized rats induced some changes in the activities of citrate-syntase, dehydrogeases of TAC and malic enzymes in the mitochondrial and cytoplasmic fractions of the brain. The most significant effect of the hormone was found in the brain of 20-day old rats there was an increase of the enzyme activities by 40--60%. The effect of the hormone on the enzymes activities could be prevented by simultaneous administration of actinomycin D (10 microgram intracerebrally). This fact indicates that the main mechanism in increasing the enzymic activity lies, probably, in stimulation of the enzyme biosynthesis by the hormone.

Aging↗