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Biomedical subjects

N D Martin

Publications and source records attributed to N D Martin.

10 recordsLinked to original sources
PubMed1987

An in vivo method for the evaluation of catheter thrombogenicity.

A new method has been developed to evaluate the relative thrombogenicity of vascular catheters. The technique provides a means to quantitatively differentiate between catheters made from different polymeric materials. Autologous In-111 labeled platelets were infused into a dog model and catheters were then inserted into the external jugular vein of the dog. The neck region was scanned using gamma camera imaging. Comparisons between catheter materials were made using computer generated uptake slopes during the first 40 min of the scan. In addition to scintigraphy, visual assessment of thrombus deposition, thrombus weight, platelet deposition, and scanning electron microscopy were used to validate the technique. Poly(vinyl chloride), polyurethane, heparinized polyurethane, and silicone catheter materials were tested. It was found that heparinized polyurethane was the least thrombogenic of all materials evaluated.

Animals↗
PubMed1986

Age at diagnosis and abilities in idiopathic hypercalcaemia.

Forty three children aged 6 to 16 years with a documented history of idiopathic infantile hypercalcaemia were assessed on a variety of cognitive and behavioural measures. No relation was found between the age at which hypercalcaemia was diagnosed and subsequent full scale intelligence quotients (IQ) and reading or spelling abilities. Verbal IQ was, however, significantly higher than performance IQ, which had an inverse relation with age at diagnosis. Furthermore, scores for deviant behaviour were found to correlate with age at diagnosis. Thus the characteristic psychological profile of this syndrome may be in part a function of hypercalcaemia during infancy.

Adolescent↗
PubMed1978

Endogenous serum TSH levels and metastatic survey scans in thyroid cancer patients using triiodothyronine withdrawal.

Using a triiodothyronine withdrawal method to produce a hypothyroid state in 38 patients with prior thyroidectomies for differentiated thyroid cancer, 56 H-TSH and T4 levels were measured prior to metastatic survey scans performed with 131I. All the T4 levels were below normal and 55 of the 56 H-TSH levels were elevated. No qualitative differences could be observed in the eight patients who had scans performed after bovine TSH injections and later after triiodothyronine withdrawal. Triiodothyronine withdrawal does induce high endogenous TSH levels and under normal circumstances bovine TSH injections are not required for metastatic scans in patients with thyroid cancer.

Adult↗
PubMed1977

Thyroid function and growth hormone secretion in amitriptyline-treated depression.

The authors studied changes in indices of thyroid function prospectively in a group of 11 patients given amitriptyline to treat depression. The drug caused no significant alteration in these indices, but scores on the Hamilton Depression Rating Scale improved significantly. In another group of subjects with depression, the stimulation of growth hormone secretion by L-dopa was unaffected by amitriptyline therapy.

Adult↗
PubMed1976

Noninvasive myocardial imaging with potassium-43 and rubidium-81 in patients with left bundle branch block.

Noninvasive myocardial imaging with potassium-43 and rubidium-81 has been used successfully to identify areas of infarction and exercise-induced ischemia as regions of decreased radioactivity. The image defects observed are believed to be due to a decreased radionuclide uptake in regions of myocardial scar or to heterogeneous myocardial accumulation of tracer as a result of regional ischemia. Of 27 patients with left bundle branch block studied with noninvasive imaging at rest and during exercise, 25 manifested at rest reduced radioactivity in the region of the interventricular septum. This pattern is similar to that seen in patients with anteroseptal myocardial infarction. Sixteen of the 27 patients underwent diagnostic coronary arteriography and left ventriculography. Only five of these patients had evidence of either previous infarction or significant obstructive coronary artery disease as assessed with clinical or angiographic criteria, or both. Although the image defect was routinely demonstrated at rest in patients with left bundle branch block, this defect was generally normalized or less distinct with exercise in patients with no anatomic heart disease. In contrast, a larger, more distinct or new image defect with exercise correctly identified the presence of significant obstructive coronary artery disease in patients with left bundle branch block. In the clinical application of noninvasive myocardial imaging, these image defects observed at rest can lead to the false pasitive radionuclide interpretation of anteroseptal myocardial infarction.

Adolescent↗
PubMed1976

A community dental health project. I. Self applied SnF2-ZrSiO4 prophylactic paste and dental caries in primary school children.

A dental health programme which employed group self prophylaxis by school children aged 5-9 years is described. The group used 10 per cent SnF2-ZrSiO4 paste and was supervised within the school by an auxiliary of parents under the direction of a dentist. There was a 36 per cent reduction in DMFT increment at the end of two years in the children aged 7-9 years.

Australia↗
PubMed1975

Scintigraphic findings in primary amyloidosis. An analysis of 7 cases.

Images of 7 patients with primary amyloidosis revealed organomegaly with regions of decreased tracer accumulation due to infiltration and replacement of normal tissue by the amyloid complex. These scintigraphic changes in the clinical setting of multisystem disease should suggest amyloidosis as a possible diagnosis.

Amyloidosis↗