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N D Nigro

Publications and source records attributed to N D Nigro.

51 records · Page 3Linked to original sources
PubMed1975

Importance of the fecal stream on the induction of colon tumors by azoxymethane in rats.

The effect of the fecal stream on intestinal carcinogenesis with azoxymethane was studied in male rats. Colostomies were performed approximately 2 cm distal to the cecum in 50 Sprague-Dawley rats to produce a 20-cm segment of nonfunctional large bowel; an additional 50 animals were left intact. Each of these groups was divided equally and was fed a normal diet or a diet containing 2% cholestyramine by weight. All animals were given azoxymethan s.c. At the end of 7 months all rats were sacrificed. The animals with colostomies developed significantly fewer tumors in the defunctionalized bowel than did intact animals in the same bowel segment. Cholestyramine appeared to increase the tumor yield in the large bowel of the intact animals but had no effect on the number of tumors in the defunctionalized bowel. Further, the intact animals on both dietary regimens developed a greater number of large tumors in the distal 20 cm of bowel. The results show that the fecal stream alters the carcinogenic activity of azoxymethane in the large bowel of the rat. It also appears that the carcinogen can reach its target tissue by a route other than the fecal stream.

Animals↗
PubMedDate not supplied

A strategy for prevention of cancer of the large bowel.

The etiology of cancer of the large bowel is in large part environmental. Both epidemiologic and experimental studies suggest that the environmental factor is dietary, specifically associated with a diet high in fat and low in fiber. Prevention is possible by altering these dietary factors, but the degree of change needed to accomplish it would be too drastic to be acceptable. However, the inclusion of certain additives in a diet only slightly modified with respect to the fat-fiber content may circumvent this problem. We have evidence that the addition of small amounts of representatives of three classes of cancer inhibitors (retinoids, plant steroids, and selenite) reduces intestinal cancer formation in rats by 50 per cent. This suggests that a diet with modest changes in the fat-fiber content plus the addition of certain inhibitors may be effective in reducing the incidence of cancer of the large bowel.

Animals↗
PubMedDate not supplied

Combined therapy for cancer of the anal canal.

Nineteen patients with squamous-cell cancer of the anal canal have been treated with combined chemotherapy and radiation therapy, followed by appropriate surgery. The authors are convinced that the combined therapy is effective enough to avoid abdominoperineal resection if disappearance of the lesion is proven by adequate examination and biopsy. Although they believe cancers 5 cm or less in maximum diameter are generally adequately managed in this manner, experience is still too limited to justify a recommendation to change currently accepted management.

Adult↗