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N D Vorob'eva

Publications and source records attributed to N D Vorob'eva.

7 recordsLinked to original sources
PubMedDate not supplied

[The effect of reaferon on the level of catecholamines and mitochondrial enzymes in the ischemic kidney].

The effect of reaferon (introduced at a dose of 1 x 10(6) IU/kg over six days prior to ischemia induction) on the levels of catecholamines and the activity of succinate dehydrogenase and NADH-dehydrogenase in various structures of kidney was studied in experiments on white rats. The ischemia was modeled by 90-min ligation of renal vessels. Reaferon retained the luminescence of catecholamines in all renal structures 24 h after circulation was restored on the level of intact kidney, except for the nerve trunks where the luminescence intensity decreased by 40%. Preliminary introduction of reaferon stimulated restoration of the enzymatic activity in the Krebs cycle and mitochondrial respiratory chain after 24- and 48-h revascularization, respectively.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Features of reoxygenation-induced damage to ischemic kidney during heparin administration].

Albino rat experiments were undertaken to examine the protective action of heparin and the specific features of secondary renal ischemic changes when the agent was administered in different doses during revascularization. Ischemia was induced by 90-min ligation of the renal vessels and the ureter. Heparin was found to have a dose-dependent capacity to prolong rats' survival after ischemia of a single kidney. There were qualitative distinctions of morphological changes in the heparin-treated kidneys as compared with those in the control.

Animals↗
PubMedDate not supplied

[The action of sulfur-containing and methemoglobin-forming compounds in renal ischemia].

Rat experiments demonstrated that cystamine showed a dose-dependent effect in renal ischemia. Ischemia was induced by ligation of renal vessels and the ureter for 90 minutes. Unithiol given in a single dose before ischemia produced no protective effect. Preadministration of sodium nitrite in doses causing slight to moderate hemic hypoxia could not diminish reoxygenation ischemic lesions.

Animals↗
PubMedDate not supplied

[The action of diuretics in renal ischemia].

A protective action of lasix, dichlothiazide, and triampur (dichlothiazide + triamterene) was studied in experiments on rats. Ischemia was simulated by obstruction of kidney vessels and ureter for 90 min. Lasix and dichlothiazide produced a protective effect in renal ischemia and at the same time resulted decrease of lifetime of experimental rats. Triampur increased the lifetime and decreased the losses of potassium in kidney tissue.

Animals↗