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Biomedical subjects

N D Yakovleva

Publications and source records attributed to N D Yakovleva.

6 recordsLinked to original sources
PubMed2003

Ultrastructure of the pineal gland after gamma-irradiation under conditions of inhibition of adrenocortical function.

Electron microscopy showed that whole-body gamma-irradiation in sublethal doses led to the appearance of injuries in pinealocytes, glial cells, and vessels of the pineal gland in rats. Limitation of the nonspecific effect of gamma-irradiation via inhibition of adrenocortical function with metopirone in physiological doses reduced the radiation-induced ultrastructural damage to the pineal gland.

Adrenal Cortex↗
PubMed2001

Ultrastructure of the rat duodenal endocrine cells after prolonged irradiation.

We propose classification of duodenal endocrine cells of intact rats based on ultrastructural signs of secretory granules and subdivided these cells into 10 basic types. The effect of long-term irradiation in a total dose of 2.5 Gy on ultrastructural organization of duodenal apudocytes was studied. Irradiation induced nonspecific changes of cell organelles in apudocytes. Differences in the ultrastructural disorganization were detected between different types of apudocyte populations and between different types of endocrine cells. Under conditions of adaptation to radiation apudocytes released the secretory product not only through molecular extrusion and exocytosis, but also via degranulation.

APUD Cells↗
PubMed2001

Age-specific ultrastructural postradiation changes in intestinal endocrine cells.

Age-specific ultrastructural postradiation changes in the main types of duodenal endocrine cells (apudocytes) were studied in rats 6 and 12 months after single whole-body irradiation in doses of 7 and 7.5 Gy. Ultrastructural disorganization of different severity was detected, which depended on apudocyte type and term postradiation. Degranulation was the basic mechanism of hormone secretion in delayed periods after the exposure.

Age Factors↗
PubMed1996

Diffuse neuroendocrine system: structural and functional effects of radiation injury to amine precursor uptake and decarboxylation (APUD) cells.

The paper presents a review of the results obtained by the authors on the study of external (gamma) and internal (I-131) radiation effects on the functional morphology and linkage of the diffuse neuroendocrine system (DNES) and amine precursor uptake and decarboxylation (APUD) cells of the stomach and duodenum. The investigations performed enabled us to determine that the morphological changes noted in APUD cells had a dose and time dependency. The present study supports the point of view that the radiation initiates serotonin release from APUD cells, which appears to initiate the mechanism of early postirradiation dysfunctions of the gastrointestinal tract and the subsequent adaptive response of DNES. Analysis of our results, together with a review of the literature, indicates that APUD cells actively participate both in pathogenesis of radiation injury and development of organ and tissue radiosensitivity.

APUD Cells↗