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N Despotović

Publications and source records attributed to N Despotović.

15 recordsLinked to original sources
PubMed1994

[Significance of monitoring histamine serum levels, cryoglobulins and complement titers during cold tests in patients with cold allergy and Raynaud's phenomenon].

The aim of our investigations is to evaluate blood histamine, complement titer and cryoglobulins before and after cold stimulation (extremity water immersion test) in patients with cold urticaria and Raynaud phenomenon. In our investigations patients were put into five groups according to the following diagnoses: cold urticaria (40 patients), chronic urticaria (15 patients), Urticaria-Vasculitis Syndrome (15 patients), Raynauds Disease (16 patients), and Raynauds phenomenon (15 patients). The investigations demonstrated that the test was always positive in cold urticaria and that a high percentage of patients had a rise in blood histamine. This was found in 50% of the patients while cryoglobulins were found in one third of the patients. Consequently they can be grouped in secondary cold urticarias. A number of patients with chronic urticaria and Urticaria-Vasculitis Syndrome gave a positive history of cold sensitivity. Positive tests were accompanied by a rise in histamine, although (less frequently) there was a decrease in the complement titer and the occurence of cryoglobulins. Raynauds Disease was accompanied by a positive test in 94% of the patients, while patients with Raynauds Phenomenon (whose etiology was Thoracic Outlet Syndrome) had a negative test (60% of the patients). Significant changes were not found in the remaining groups. Positive tests were accompanied by abnormal values of cryoglobulins and of complement titer as well as an increase in histamine. The rise in histamine was not significant in Raynauds Phenomenon, while one patient had a decrease in the complement titer and the appearance of cryoglobulins.

Adolescent↗
PubMed1991

[Clinico-laboratory characteristics of physical urticaria].

Physical urticarias represent a specific reaction of the skin, which is characterised by local erythema, edema and pruritus at the site where the physical stimulus has been applied. However, local changes can be associated with various systemic manifestations. Specific cutaneous reactions due to physical factors may be the first manifestation of a systemic and/or infectious disease, which should be taken into account as physical urticarias generally occur in young patients. In view of the above mentioned, as well as unpredictable course of the disease and relatively limited therapeutic effects, the etiology and pathogenesis of the physical urticarias are one of the most interesting fields of investigation in contemporary medicine.

Adult↗
PubMed1991

[Effect of ranitidine on the pharmacokinetics of theophylline in patients with obstructive pulmonary disease].

Investigations were performed on 20 patients with mild and moderately severe forms of bronchiale asthma or chronic obstructive bronchitis. Theophylline for oral use (sustained release form) and Ranitidine (second generation H2-blocker) were used in the first group of patients (7 females and 3 males, average age 37.9). Dosage of theophylline from patients sera was monitored at 3, 6 and 12 hours, beginning with the initial morning dose. The second group of patients (9 females and 1 male, average age 46.3) were on Ranitidine therapy, along with 250 mg intravenous theophylline-ethylene-diamine. Fractionated dosage of theophylline was done within 12 hours. Pharmacokinetic parameters were calculated according to the concentration of theophylline in the sera of patients in the second group. Significant differences were not found by statistical analysis (T-test) in the pharmacokinetic parameters of theophylline although significantly higher concentrations of theophylline were found in the sera of patients in the first group. This indicated that there are individual differences on the metabolism of theophylline drugs with concomitant use of Ranitidine.

Adult↗
PubMed1991

[Laboratory study of patients with endemic nephropathy].

The introduction deals with the main characteristics of two representatives of high risk pregnancies: diabetes mellitus and EPH gestoses. Particular interest was shown in risks that may occur in pregnant diabetics, with which they must be acquainted. Some theories are given on the pathogenesis of EPH gestoses. The aim of our investigation was to determine the concentration at which immunoglobulins G, M and A pass in cord blood, amniotic fluid and urine, and whether there is a significant difference between control group and among pregnant diabetics or those with EPH gestoses. The investigation was performed by the nephelometric technique on the Immunochemistry Analyzer. Each group consisted of 20 women, with a total of 60. Immunoglobulins A, M and G were determined in the mothers' sera, cord blood or amniotic fluid. IgG was obtained in urine in measurable concentrations. A significant increase of IgG was found in the urine of pregnant diabetics. IgM was significantly increased in the sera of diabetic mothers. IgA was significantly increased in pregnant diabetics, while both high risk pregnancy groups had an increased IgA in cord blood. The values of IgA in amniotic fluid were decreased in the EPH gestoses group in comparison to the group of diabetics. The authors find these variations interesting and feel they should be followed in other high risk pregnancy groups.

Balkan Nephropathy↗
PubMed1990

Levamisole treatment of oligospermia.

On the basis of elevated levels of seminal plasma immunoglobulins and a decreased production of LMI in the presence of PPD, 6 patients (out of the idiopathic normogonadotrophic oligospermic group) were selected for a therapeutic trial with levamisole. The following regime of treatment was applied: 3 days on levamisole (150 mg per day) followed by a 10 day interval without treatment, for a period of three months. The sperm count increased in 5 out of 6 patients and motility increased in 2. At the same time a reduction in seminal plasma IgG levels was observed in all treated patients. A significant increase of EA rosettes was observed after treatment.

Cell Migration Inhibition↗
PubMed1987

Delayed-type allergy against various insulin preparations including human semisynthetic insulin.

The authors present a patient with delayed-type allergy against insulin preparations of different species including highly purified monocomponent insulin and human semisynthetic insulin. Positive results for cutaneous delayed-type hypersensitivity and for lymphocyte blastogenesis suggested a type IV immunopathogenic reaction. Intradermal tests performed with various components of insulin preparations revealed delayed-type allergy to insulins of different species (bovine, porcine and human) but not to any of the other components.

Drug Hypersensitivity↗
PubMedDate not supplied

[The effect of ranitidine on theophylline pharmacokinetics in patients with obstructive lung disease].

The study was performed in 20 patients with mild and moderately severe forms of bronchial asthma or chronic obstructive bronchitis. Theophylline for oral use (sustained release form) and ranitidine was used in the first group of patients (7 females and 3 males, mean years of age 37.9). Dosage of theophylline from patients' sera was monitored prior and at 3, 6, and 12 hours beginning with the initial morning dose. The second group of patients (9 females and 1 male, mean age 46.3 years) were on ranitidine therapy along with 250 mg intravenous theophylline-ethylene-diamine. Fractionated dosage of theophylline was made within 12 hours. Pharmacokinetic parameters were calculated according to the concentration of theophylline in the sera of patients in the second group. In the sera of patients in the first group significantly higher concentrations of theophylline were found at 3 and 6 hour of the initial morning dose (p less than 0.05). In the second group a significant difference was not registered for the assessed pharmacokinetic parameters. This investigation indicates that there are individual differences of the metabolism of theophylline drugs with concommitant use of ranitidine.

Adult↗
PubMedDate not supplied

[The oral milk provocation test in patients with chronic urticaria].

Histamine and sera complement were followed-up in patients with chronic urticaria during oral provoking test to cow milk. Three patients with a positive history to cow milk sensitisation showed a significant decrease in C3 concentration within 180 minutes of the test. This was followed by increased histamine and skin eruption. According to our results (skin test reactivity and clinical evaluation of the provoking test) several mechanisms were involved in the sensitisation to cow milk in our patients.

Adult↗
PubMedDate not supplied

[Histologic manifestations in the skin in alpha-lactoalbumin intradermal tests in patients with chronic urticaria].

Intradermal injection with alpha-lactoalbumine, 2000 PNU/ml was carried out in seven patients (1 male, 6 females, mean age 32.4 years) suffering from milk intolerance. None of the patients had a positive allergen-specific IgE antibodies in the sera (RAST). Skin test was performed on the volar part of the forearms at the same time. The area of skin reaction was estimated and measured within 36 hours on the right arm. Skin biopsy was done with a 4 mm punch after 8 hours from site of antigen injection on the left arm. Various cells infiltrating the site of antigen instillation were present. Leukocytoclastic vasculitis was only found in patients with dual intradermal reaction (immediate and late onset of response; 8 12 hours). These results indicate that local skin reaction to alpha-lactoal-bumine is mediated by diverse immune mechanisms, and that it may be of clinical significance for the diagnosis of cow milk allergy in adults.

Adult↗