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N Dorairajan

Publications and source records attributed to N Dorairajan.

10 recordsLinked to original sources
PubMed2005

Review analysis of medullary carcinoma thyroid--15-year Indian experience.

To emphasize the importance of adequate primary surgery in cases of medullary carcinoma of the thyroid, 44 cases of treated medullary carcinoma of thyroid were retrospectively reviewed in Government General Hospital, Chennai between 1987 and 2002. Patients who underwent total thyroidectomy with only central compartment dissection were compared with those who had undergone total thyroidectomy with meticulous triple compartment (bilateral lateral and central groups) nodal dissection. The group of total thyroidectomy with only central compartment dissection had high rate of lymph nodal recurrence and persistent hypercalcitoninaemia when compared with the group of total thyroidectomy with meticulous triple compartment nodal dissection. (Chi square value 4.503 with p<0.05).

Adult↗
PubMed2002

A descriptive study of papillary thyroid carcinoma in a teaching hospital in Chennai, India.

OBJECTIVE: In the 1994 Chennai population-based cancer registry, thyroid carcinoma constituted 1% and 2% of all incident cancers among males and females, respectively. The aim of our study was to conduct an epidemiological survey of the pattern of papillary thyroid carcinoma in the Chennai Government General Hospital and the Chennai Cancer Institute. METHODS: Our data base included a total of 264 (58 males and 206 females) consecutive cases of papillary thyroid carcinoma admitted to the Government General Hospital and 164 (42 males and 122 females) cases from the Chennai Cancer Institute. RESULTS: There was a female preponderance (100 males and 328 females) (p < 0.001). The median age at diagnosis was 39 years among males and 32 years among females. The distribution of cases by residential area lay scattered from < 1 km to > 100 km, with the majority (28%) from the city of Chennai and its suburbs in the Government General Hospital, while 52% of the cases in the cancer institute were from the neighbouring state. Iodine intake was present in 75% of cases (p < 0.001). The diagnosis of thyroid cancer was confirmed by fine needle aspiration cytology in most (88%) of the cases. The extent of disease in the Government General Hospital and the Cancer Institute were as follows: localized in 66% vs 32%; spread to surrounding structure with or without nodal involvement in 26% and 59% presence of only secondary nodal involvement in 3% and 1%, distant metastasis in 5% and 8%, respectively. The primary modality of treatment was surgery with total thyroidectomy being performed in 82%, while the rest underwent a hemithyroidectomy. CONCLUSION: The cumulative life-time risk of thyroid cancer in Chennai was one in 970 in males and one in 565 in females. High dietary intake of iodine was the most significant risk factor for the etiology of papillary thyroid carcinoma in our study.

Adult↗
PubMed1999

Surgical treatment of endocrine hypertension experience in India.

Between 1980 and 1994, 162 cases of endocrine based hypertension were diagnosed and treated surgically. Seventy-nine cases (48.7%) of phaeochromocytoma, 63 cases (38.8%) of Cushing's syndrome, and 20 cases (12.3%) of Conn's syndrome were diagnosed. In phaeochromocytoma 75% of the tumours arose from the adrenal glands and 25% arose from the extra-adrenal sites. Cushing's syndrome was caused by adenoma (45%), diffuse bilateral adrenal hyperplasia (36%), pigmented macronodular hyperplasia (9%), and adrenal carcinoma (10%). The most common cause of Conn's syndrome was adenoma (95%) which arose mainly from the left adrenal gland (60%). In the present series the success rate of surgical treatment was 100% for phaeochromocytoma, 90% for Cushing's syndrome and 96% for Conn's syndrome. Trucut biopsy of the kidneys of these patients showed hypertensive changes, the moderate hypertension could be due to renal damage.

Adrenal Gland Neoplasms↗
PubMed1996

Solitary nodule of the thyroid and the role of fine needle aspiration cytology in diagnosis.

In this study the pre-operative diagnostic procedures carried out on 100 patients with clinically solitary nodule of the thyroid experienced over a period of one year with special emphasis on the usefulness of fine needle aspiration biopsy cytology (FNAC) was evaluated retrospectively. All of the 100 patients underwent operation except 2 patients with FNAC diagnosis of Hashimoto's thyroiditis and 7 patients with FNAC diagnosis of colloid goitre. Histopathological study of surgically resected specimens in 91 patients revealed 67 adenomas, one subacute thyroiditis, 3 Hashimoto's thyroiditis, 8 follicular carcinomas, 11 papillary carcinomas and one medullary carcinoma. FNAC tallied in 95% of cases. It was false positive in 2 cases (one case of subacute thyroiditis and one case of Hashimoto's thyroiditis), false negative in one case (a case of follicular carcinoma) and non-diagnostic in 2 cases (2 cases of Hashimoto's thyroiditis).

Adolescent↗
PubMedDate not supplied

Salivary gland tumors: a 10-year retrospective study of survival in relation to size, histopathological examination of the tumor, and nodal status.

Salivary gland neoplasms represent the most complex and diverse group of tumors encountered by the head and neck oncologist. Their diagnosis and management is complicated by their relative infrequency. The significance of the study was to analyze the different types of salivary gland tumors, the modalities of treatment given, and their varied outcomes in relation with morbidity, prognosis, and survival rate. A total of 436 patients were treated for salivary gland neoplasm at Madras Medical College and Research Institute between 1991 and 2001, and the results were analyzed retrospectively. The patients were between 11 and 72 years of age (mean, 41.5 years), and 334 were male and 102 were female. They were from different socioeconomic groups. Fine-needle aspiration cytology was done for all patients that presented with salivary gland swelling. Univariate analysis was done, the confidence interval and odds ratio were calculated, and the significance was noted. Kaplan-Meier survival analysis was estimated, and the results were analyzed. Pleomorphic adenoma was the most common benign tumor affecting the salivary glands. In our series, 155 patients had malignant parotid gland neoplasms, and 20 patients had cervical lymph node metastasis at the time of presentation. Facial nerve paralysis was noted in 21 cases. The recurrence after total parotidectomy for malignant salivary gland tumors was effectively managed with external beam irradiation in 19 patients. The survival, prognosis, and the mortality rate of the malignant parotid neoplasms and their relation to the sex of the patient, histopathological type of tumor, nodal status, and size of the tumor were analyzed.

Adenoma, Pleomorphic↗
PubMedDate not supplied

Management of incidentalomas of the adrenal gland in an Indian hospital set-up between 1991 and 2000.

The use of imaging techniques and their increasing sensitivity have resulted in increased detection of incidentalomas of the endocrine organs. The aim of our study was to review the currently used evaluation schemes and the outcomes of surgical and conservative management of adrenal incidentalomas at an Indian center. Fifty-eight cases of adrenal incidentalomas diagnosed and treated at the Govt. General Hospital, Chennai, and private practice were reviewed. Ultrasonogram of the abdomen was the most frequently used investigation (88%). The common complaint was upper abdominal discomfort. The mean duration of treatment of symptoms before diagnosis was 3.5 months. Thirty-three cases underwent adrenalectomy. The cases not subjected to resection were followed every 6 months for 2 years and follow-up ceased if no increase in size was detected. Of these, two patients required subsequent adrenalectomy. Thirty-six of these tumors were eventually detected to be nonfunctioning adenomas, of which 15 underwent resection because of size >3 cm. Cortical carcinoma was detected in nine patients, pheochromocytoma in seven, myelolipoma in one, metastatic tumor in one, and cyst, ganglioneuroma, and tuberculoma in four. Of these, 20 developed features of hypersecretion during preparation for surgery. In tumors between 3 and 5 cm, in view of noncompliance of patients to repeated follow-up and cost factors, surgery was considered the most effective treatment option. There is a need for prospective studies to formulate diagnostic and treatment strategy.

Adrenal Cortex Neoplasms↗
PubMedDate not supplied

Review analysis of medullary carcinoma of the thyroid: a 15-year Indian experience.

The aim of this study was to emphasize the importance of adequate primary surgery in cases of medullary carcinoma of the thyroid. We retrospectively reviewed 44 cases of medullary carcinoma of the thyroid treated in Government General Hospital, Chennai between 1987 and 2002. Patients who underwent total thyroidectomy with only central compartment dissection were compared with those who had undergone total thyroidectomy with meticulous triple compartment (bilateral lateral and central groups) nodal dissection. The group of total thyroidectomy with only central compartment dissection had a high rate of lymph nodal recurrence and persistent hypercalcitoninemia compared with the group with total thyroidectomy with meticulous triple compartment nodal dissection. (chi square, 4.503; P > 0.05). Primary surgery with total thyroidectomy with meticulous triple compartment dissection is superior to total thyroidectomy with central compartment dissection alone in terms of preventing nodal and local recurrences and achieving normal (basal and stimulated) serum calcitonin levels postoperatively.

Adult↗